المؤلفون: Ma LN; Ningxia Medical University, Yinchuan, 750004, Ningxia, China., Ma Y; Ningxia Medical University, Yinchuan, 750004, Ningxia, China., Luo X; Department of Infectious Disease, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China., Ma ZM; Xinasheng Biotech of Ningxia, Yinchuan, 750004, Ningxia, China., Ma LN; Department of Infectious Disease, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China. 13619511758@163.com., Ding XC; Department of Infectious Disease, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China. 13619511768@163.com.

المصدر: Scientific reports [Sci Rep] 2024 May 27; Vol. 14 (1), pp. 12149. Date of Electronic Publication: 2024 May 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/mortality , Carcinoma, Hepatocellular*/metabolism , Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/immunology , Liver Neoplasms*/mortality , Liver Neoplasms*/metabolism , Gene Expression Regulation, Neoplastic* , Aldo-Keto Reductase Family 1 member B10*/genetics , Aldo-Keto Reductase Family 1 member B10*/metabolism, Humans ; Male ; Female ; Prognosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Middle Aged ; Kaplan-Meier Estimate ; Aldo-Keto Reductases/genetics ; Aldo-Keto Reductases/metabolism ; Gene Expression Profiling ; Computational Biology/methods

المؤلفون: Orita N; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Kawaguchi K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. Electronic address: kawaguchi@m-kanazawa.jp., Honda M; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Shimode T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Hayakawa N; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Terashima T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Komura T; Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan., Nishikawa M; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Horii R; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Nio K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Shimakami T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Takatori H; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Arai K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Sakai Y; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Mizukoshi E; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Kaneko S; Department of Information-Based Medicine Development, Kanazawa University Graduate School of Medicine, Kanazawa, Japan., Kagaya T; Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Sep 24; Vol. 674, pp. 133-139. Date of Electronic Publication: 2023 Jul 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B, Chronic*/complications , Hepatitis B, Chronic*/drug therapy , Liver Neoplasms*/pathology , Aldo-Keto Reductase Family 1 member B10* , Carcinoma, Hepatocellular*/pathology, Humans ; Lamivudine/therapeutic use ; Tenofovir ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Aldo-Keto Reductases

المؤلفون: Nagini S; World Neem Organization, Mumbai, 400101, India., Kallamadi PR; Department of Biochemistry, ICMR-National Institute of Nutrition, Hyderabad, 500007, India., Tanagala KKK; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, 10032, USA., Reddy GB; Department of Biochemistry, ICMR-National Institute of Nutrition, Hyderabad, 500007, India.

المصدر: Oncology research [Oncol Res] 2024 Jul 17; Vol. 32 (8), pp. 1287-1308. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/enzymology , Neoplasms*/pathology , Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Aldo-Keto Reductases*/antagonists & inhibitors , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Animals ; Enzyme Inhibitors/therapeutic use ; Enzyme Inhibitors/pharmacology ; Precision Medicine ; Signal Transduction ; Aldehyde Reductase/antagonists & inhibitors ; Aldehyde Reductase/metabolism

المؤلفون: Zhang W; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China., Shao ZQ; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China., Wang ZX; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China., Ye YF; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China., Li SF; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China., Wang YJ; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: wangyj@zjut.edu.cn.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug; Vol. 274 (Pt 1), pp. 133264. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Aldo-Keto Reductases*/chemistry , Biocatalysis* , Alcohols*/chemistry , Alcohols*/metabolism , Enzymes, Immobilized*/chemistry , Enzymes, Immobilized*/metabolism, Stereoisomerism ; Bioreactors

المؤلفون: Shanbhag AP; Bugworks Research India Pvt. Ltd., Bengaluru, Karnataka, India.; Novartis Healthcare Pvt. Ltd., Hyderabad, Telangana, India., Bhowmik P; Bugworks Research India Pvt. Ltd., Bengaluru, Karnataka, India.; Centre for Cellular and Molecular Platforms (C-CAMP), National Centre for Biological Sciences (NCBS), Bengaluru, Karnataka, India.

المصدر: The Yale journal of biology and medicine [Yale J Biol Med] 2024 Jun 28; Vol. 97 (2), pp. 179-204. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Yale Journal of Biology and Medicine Country of Publication: United States NLM ID: 0417414 Publication Model: eCollection Cited Medium: Internet ISSN: 1551-4056 (Electronic) Linking ISSN: 00440086 NLM ISO Abbreviation: Yale J Biol Med Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Cataract*/enzymology , Cataract*/genetics , Cataract*/metabolism , Neoplasms*/enzymology , Neoplasms*/genetics, Humans ; Chronic Disease

المؤلفون: Štěrbová K; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Raisová Stuchlíková L; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Rychlá N; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Kohoutová K; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Babičková M; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Skálová L; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic., Matoušková P; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203/8, Hradec Králové, Czech Republic. Electronic address: matousp7@faf.cuni.cz.

المصدر: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2024 Aug; Vol. 25, pp. 100555. Date of Electronic Publication: 2024 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3207 (Electronic) Linking ISSN: 22113207 NLM ISO Abbreviation: Int J Parasitol Drugs Drug Resist Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases*/genetics , Aldo-Keto Reductases*/metabolism , Haemonchus*/genetics , Haemonchus*/drug effects , Haemonchus*/enzymology , Phylogeny* , Mebendazole*/pharmacology , Mebendazole*/analogs & derivatives, Animals ; Female ; Male ; Drug Resistance/genetics ; Sheep ; Anthelmintics/pharmacology ; Transcriptome ; Aldehyde Reductase/genetics ; Aldehyde Reductase/metabolism ; Humans ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/enzymology ; Benzimidazoles/pharmacology

المؤلفون: Andress Huacachino A; Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA; Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA., Joo J; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA., Narayanan N; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA., Tehim A; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA., Himes BE; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA; Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA., Penning TM; Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104-6061, USA. Electronic address: penning@upenn.edu.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2024 Aug 01; Vol. 398, pp. 111111. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Aldo-Keto Reductases*/chemistry , Databases, Protein*, Humans ; Internet ; Aldehyde Reductase/metabolism ; Aldehyde Reductase/chemistry ; Aldehyde Reductase/genetics ; Animals

المؤلفون: Kong D; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Wu Y; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China; The Second Medical College, Binzhou Medical University, Yantai, China., Tong B; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Liang Y; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Xu F; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Chi X; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Ni L; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Tian G; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Zhang G; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China., Xu Z; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy, Binzhou Medical University, Yantai, China. Electronic address: zhaoweixv@bzmc.edu.cn.

المصدر: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Aug; Vol. 1870 (6), pp. 167214. Date of Electronic Publication: 2024 May 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

مواضيع طبية MeSH: Aldehyde Reductase*/metabolism , Aldehyde Reductase*/genetics , Aldehyde Reductase*/antagonists & inhibitors , Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/drug therapy , Cellular Senescence*/drug effects , Gemcitabine* , Gene Expression Regulation, Neoplastic*/drug effects , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/drug therapy, Animals ; Humans ; Mice ; Carcinogenesis/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Proliferation ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Mice, Nude ; Oleanolic Acid/pharmacology ; Oleanolic Acid/analogs & derivatives

المؤلفون: Tan C; Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Zhiyuan Road, Guilin, 541199, Guangxi, People's Republic of China., Zeng X; Department of Occupational and Environmental Health, School of Public Health, Guilin Medical University, Zhiyuan Road, Guilin, 541199, Guangxi, People's Republic of China., Guo X; Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Zhiyuan Road, Guilin, 541199, Guangxi, People's Republic of China., Mo M; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China., Ma X; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China., Liu B; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China., Liu S; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China., Zeng X; Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Zhiyuan Road, Guilin, 541199, Guangxi, People's Republic of China., Huang D; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China., Qiu X; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China. qiuxiaoqiang@gxmu.edu.cn.

المصدر: Digestive diseases and sciences [Dig Dis Sci] 2024 Jul; Vol. 69 (7), pp. 2502-2521. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases*/genetics , Aldo-Keto Reductases*/metabolism , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Gene Expression Regulation, Neoplastic* , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism, Female ; Humans ; Male ; Middle Aged ; Aldehyde Reductase/genetics ; Aldehyde Reductase/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression

المؤلفون: Mann G; School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Mora S; School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Adegoke OAJ; School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada.

المصدر: PloS one [PLoS One] 2024 Aug 20; Vol. 19 (8), pp. e0309324. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Leucine*/metabolism , Leucine*/pharmacology , Signal Transduction*/drug effects , Insulin*/metabolism , Insulin*/blood , Rats, Sprague-Dawley* , Insulin Resistance* , Keto Acids*/metabolism, Animals ; Male ; Rats ; Phosphorylation/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Insulin Receptor Substrate Proteins/metabolism ; Liver/metabolism ; Liver/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/drug effects