نتائج البحث - "mAb - monoclonal antibody"

المصدر: Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 6, Iss 1, Pp 69-76 (2022)

مصطلحات موضوعية: Medicine (General), R5-920, FDA, US Food and Drug Administration, PML, progressive multifocal leukoencephalopathy, Original Article, NA, not applicable, mAb, monoclonal antibody, BBW, black box warning, IQR, interquartile range

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b96e5615755d7c31a16937dafc148
https://doi.org/10.1016/j.mayocpiqo.2021.11.009

View record from ScienceDirect

Full Text via ClinicalKey

7

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

المؤلفون: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)

مصطلحات موضوعية: SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, RC799-869, PE, phosphatidylethanolamine, ER, endoplasmic reticulum, PC, phosphatidylcholine, Mice, FLD, fatty liver disease, PCR, polymerase chain reaction, VLDL, very low density lipoprotein, Non-alcoholic Fatty Liver Disease, Animals, mAb, monoclonal antibody, RIPA, radioimmunoprecipitation assay buffer, SER, smooth endoplasmic reticulum, Triglycerides, Original Research, Liver Perfusion, KO, knockout, Hepatology, CE, cholesteryl ester, TG, triglyceride, S2, second supernatant, ACSL5, acyl-CoA synthetase long chain family member 5, Gastroenterology, Membrane Proteins, IP, immunoprecipitation, Diseases of the digestive system. Gastroenterology, LC-MS/MS, liquid chromatography–mass spectrometry, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, WT, wild-type, Rats, Fatty Liver, ERGIC, endoplasmic reticulum–Golgi intermediate compartment, RER, rough endoplasmic reticulum, TM6SF2, transmembrane 6 superfamily 2, Apo, apolipoprotein, PI, protease inhibitor cocktail, UTSW, University of Texas Southwestern Medical Center, PFA, paraformaldehyde, VLDL

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291c
http://europepmc.org/articles/PMC8804273

View record from ScienceDirect

Full Text via ClinicalKey

8

Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers

المؤلفون: Benjamina Esapa, Jiexuan Jiang, Anthony Cheung, Alicia Chenoweth, David E. Thurston, Sophia N. Karagiannis

المصدر: Esapa, B, Jiang, J, Cheung, A, Chenoweth, A, Thurston, D & Karagiannis, S N 2023, ' Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers ', Cancers, vol. 15, no. 6, 1845 . https://doi.org/10.3390/cancers15061845

مصطلحات موضوعية: Cancer Research, TARGET, Oncology, IgG, Antibody-drug conjugates (ADC), ANTIGEN, mAb—monoclonal antibody, Fab regions, effector functions, Checkpoint inhibitors, Cancer Immunotherapy, Monoclonal Antibodies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a144c2a1792fe8deeafa3a9445956b80
https://doi.org/10.3390/cancers15061845

Find this article in full text from ProQuest

9

Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis

المؤلفون: Antonella D'Amore, Angela Acciarito, Antonino Moschella, Zeeshan Ali, Khouloud Boujnah, Saverio Alberti, Anna Laura Aloisi, Pasquale Simeone, Rossano Lattanzio, Paola Zanna, Giovanna Vacca, Marco Trerotola, Emanuela Guerra, Martina Ceci, Valeria Garbo

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 415-428 (2021)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: 0301 basic medicine, LUADs, lung adenocarcinomas, Models, Molecular, Cancer Research, LUSCs, lung squamous cell cancers, SCC, squamous cell carcinoma, Metastasis, ADAM10 Protein, Mice, Cell growth, 0302 clinical medicine, Neoplasms, Neoplasm Metastasis, Original Research, Signaling activation, ADAM, a disintegrin and metalloproteinase, Mice, Inbred BALB C, medicine.diagnostic_test, Chemistry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Transmembrane protein, 030220 oncology & carcinogenesis, MCF-7 Cells, HT29 Cells, Signal Transduction, wt, wild-type, Proteolysis, Transplantation, Heterologous, Molecular modeling, Cleavage (embryo), lcsh:RC254-282, 03 medical and health sciences, Antigens, Neoplasm, Cell Line, Tumor, medicine, Animals, Humans, Amino Acid Sequence, mAb, monoclonal antibody, Cell Proliferation, Activator (genetics), Cell Membrane, Cancer, Membrane Proteins, Epithelial Cells, medicine.disease, HCT116 Cells, Proteolytic processing, Trop, 030104 developmental biology, RIP, regulated intramembrane proteolysis, Cancer cell, Human cancer, Cancer research, Amyloid Precursor Protein Secretases, Cell Adhesion Molecules, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301cd7c391b29616c20ccc6f7b54ded
http://www.sciencedirect.com/science/article/pii/S1476558621000166

View record from ScienceDirect

Full Text via ClinicalKey

10

Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNASummary

المؤلفون: Jie Zan, Bi Wang, Xuya Zhao, Xiya Deng, Hongda Ding, Zijing Wei, Shuai Wang, Zhi Huang, Minyi Lu

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 465-487 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, T-Lymphocytes, medicine.medical_treatment, FISH, fluorescence in situ hybridization, RC799-869, IFN-γ, interferon γ, SOCS1, suppressor of cytokine signaling 1, AAV, adeno-associated virus, 0302 clinical medicine, IRF9, interferon regulatory factor 9, Original Research, Receptors, Interferon, Gene knockdown, JAK-STAT, Janus kinase-signal transducer and activator of transcription, Cell Death, Liver Neoplasms, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, RNA-Binding Proteins, RIP, RNA immunoprecipitation, Diseases of the digestive system. Gastroenterology, lncRNA-NEAT1, long non-coding RNA nuclear enriched abundant transcript 1, Adoptive Transfer, DNA-Binding Proteins, Immunosurveillance, Blot, PD-L1, programmed cell death-ligand 1, Hepatocellular carcinoma, IFNGR1, interferon gamma receptor 1, Paraspeckle, 030211 gastroenterology & hepatology, Immunotherapy, IP, intraperitoneal, NONO, non-POU domain-containing octamer-binding protein, Carcinoma, Hepatocellular, RBP, RNA binding protein, Thr, threonine, PBS, phosphate-buffered saline, Ser, serine, Biology, Interferon-gamma, 03 medical and health sciences, Paraspeckles, Cell Line, Tumor, medicine, Humans, RNA, Messenger, mAb, monoclonal antibody, PSPC1, paraspeckle component 1 protein, neoplasms, PD1, programmed death 1, Immune Evasion, KO, knockout, Hepatology, SFPQ, splicing factor proline- and glutamine-rich protein, Tyr, tyrosine, Hepatocellular Carcinoma, Long Non-coding RNA Nuclear Enriched Abundant Transcript 1, CXLR4, C-X-C motif chemokine receptor 4, medicine.disease, WT, wild-type, digestive system diseases, si, short interfering, RRM, RNA recognition motif, Cytolysis, Non-POU Domain-Containing Octamer-Binding Protein, 030104 developmental biology, NEDD4-1, neuronally expressed developmentally down-regulated 4, Cancer research, Interferon Gamma Receptor 1, ISG, IFN-stimulated gene, HCC, hepatocellular carcinoma, SD, standard deviation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ab4ee8ec76c4cf013b60b95b4da027
http://www.sciencedirect.com/science/article/pii/S2352345X21000436

تنقيح النتائج