المؤلفون: Thomas A. Leonard, John E. Burke, Kaelin D. Fleming, Daniel Pokorny, Linda Truebestein

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Phosphatidylinositol 3,4-bisphosphate, hydrogen–deuterium exchange mass spectrometry (HDX-MS), Sgk3, serum/glucocorticoid-regulated kinase 3, Serine threonine protein kinase, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Phosphatidylinositol Phosphates, Neoplasms, Sgk3, PI(3,4)P2, phosphatidylinositol 3,4,-bisphosphate, biology, Chemistry, Kinase, serine/threonine protein kinase, Cell biology, CISK, HDX-MS, hydrogen–deuterium exchange mass spectrometry, mTORC2, mammalian target of rapamycin complex 2, Protein Structural Elements, PDK1, 3-phosphoinositide-dependent protein kinase 1, PI3K, phosphoinositide 3-kinase, Research Article, Signal Transduction, Class I Phosphatidylinositol 3-Kinases, Endosomes, In Vitro Techniques, Protein Serine-Threonine Kinases, 03 medical and health sciences, phosphatidylinositide 3-kinase (PI 3-kinase), PKC, protein kinase C, Humans, Phosphatidylinositol, Vps34, vacuolar protein sorting 34, Molecular Biology, endosome, phospholipid, Phosphoinositide 3-kinase, INPP4, inositol polyphosphate-4-phosphatase, 030102 biochemistry & molecular biology, Phosphatidylinositol (3,4,5)-trisphosphate, Phosphatidylinositol 3-phosphate, Cell Biology, PX domain, GSK3β, glycogen synthase kinase-3 beta, Class III Phosphatidylinositol 3-Kinases, allosteric regulation, PI(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate, 030104 developmental biology, PI3P, phosphatidylinositol 3-phosphate, SHIP2, SH2-containing inositol 5′ phosphatase, Liposomes, biology.protein, EEA1, early endosome antigen 1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eeb1421116084a162e9fdd277d64988
http://europepmc.org/articles/PMC8318898

المؤلفون: Ayako Makino, Ankit A. Desai, Ramon J. Ayon, Yali Gu, Ziyi Wang, Qian Zhang, Guofei Zhou, Shanshan Song, Franz Rischard, Jiwang Chen, Jason X.-J. Yuan, Kang Wu, Sujana Vinjamuri, Angela Balistrieri, Haiyang Tang, Rebecca Vanderpool, Joe G.N. Garcia, Jian Wang, Stephen M. Black

المصدر: JACC. Basic to translational science, vol 3, iss 6
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 744-762 (2018)

مصطلحات موضوعية: phosphatase and tensin homolog, lcsh:Diseases of the circulatory (Cardiovascular) system, Raptor, regulatory associated protein of mammalian target of rapamycin, PH, Rictor, rapamycin insensitive companion of mammalian target of rapamycin, mTORC1, right ventricle, Pharmacology, Cardiovascular, PI3K, mTORC2, platelet-derived growth factor, smooth muscle, PRECLINICAL RESEARCH, GPCR, 0302 clinical medicine, pulmonary arterial hypertension, PASMC, Lung, PDGFR, platelet-derived growth factor receptor, WT, mTORC1, mammalian target of rapamycin complex 1, rapamycin insensitive companion of mammalian target of rapamycin, HPH, hypoxia-induced pulmonary hypertension, PAEC, 3. Good health, pulmonary arterial endothelial cell, TKR, endothelial cell, Cardiology and Cardiovascular Medicine, PA, Clinical Sciences, phosphorylated AKT, 03 medical and health sciences, Right ventricular hypertrophy, pulmonary artery, G protein-coupled receptor, GPCR, G protein-coupled receptor, pulmonary arterial smooth muscle cell, EC, endothelial cell, mammalian target of rapamycin complex 2, mammalian target of rapamycin complex 1, medicine.disease, pAKT, phosphorylated AKT, WT, wild-type, 030104 developmental biology, lcsh:RC666-701, 0301 basic medicine, PTEN, PVR, Cardiorespiratory Medicine and Haematology, 030204 cardiovascular system & hematology, PDGF, platelet-derived growth factor, SM, smooth muscle, RVSP, hypoxia-induced pulmonary hypertension, RVSP, right ventricular systolic pressure, pulmonary hypertension, right ventricular hypertrophy, regulatory associated protein of mammalian target of rapamycin, SM, phosphoinositide 3-kinase, PDGF, PAEC, pulmonary arterial endothelial cell, Raptor, PA, pulmonary artery, Heart Disease, medicine.anatomical_structure, HPH, pulmonary vascular resistance, mTORC2, mammalian target of rapamycin complex 2, mTOR, PAH, pulmonary arterial hypertension, PI3K, phosphoinositide 3-kinase, PASMC, pulmonary arterial smooth muscle cell, PDGFR, Forkhead box O3a, pAKT, PH, pulmonary hypertension, PVR, pulmonary vascular resistance, Rictor, FOXO3a, Forkhead box O3a, Rare Diseases, Growth factor receptor, TKR, tyrosine kinase receptor, medicine, right ventricular systolic pressure, FOXO3a, PI3K/AKT/mTOR pathway, wild-type, EC, business.industry, RVH, right ventricular hypertrophy, PAH, platelet-derived growth factor receptor, Pulmonary hypertension, PTEN, phosphatase and tensin homolog, Vascular resistance, tyrosine kinase receptor, business, RVH

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d147fc74d88a884f1e521e7ef3c53
https://doi.org/10.1016/j.jacbts.2018.08.009

المؤلفون: Jessica Guenzle, Sven A. Lang, Hans J. Schlitt, Peter Bronsert, Christine Wagner, Katharina Schmidt, Claus Hellerbrand, Peter Dietrich, Christina Hackl, Edward K. Geissler, Stefan Fichtner-Feigl

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 12, Pp 1198-1208 (2018)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Melanoma, Experimental, Medizin, Gene Expression, mTORC2, Metastasis, Mice, 0302 clinical medicine, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium, Cell Movement, GEO, Gene Expression Omnibus, RNA, Small Interfering, Melanoma, CM, conditioned media, Chemistry, Liver Neoplasms, digestive, oral, and skin physiology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Tumor Burden, AGC kinase, protein kinase A, G, and C families (PKA, PKC, PKG), Gene Knockdown Techniques, 030220 oncology & carcinogenesis, mTORC2, mammalian target of rapamycin complex 2, RNA Interference, RICTOR, Rapamycin-Insensitive Companion of mTOR, Hepatocyte growth factor, αSMA, α smooth muscle actin, HSC, hepatic stellate cells, Signal Transduction, DMEM, Dulbecco’s Modified Eagle Medium, medicine.drug, RAPTOR, Regulatory-Associated Protein of mTOR, Original article, BrdU, 5′-bromodeoxyuridine, Mechanistic Target of Rapamycin Complex 2, lcsh:RC254-282, NHEM, normal human epidermal melanocyte, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, 4E-BP-1, 4E-binding protein 1, PI3K/AKT/mTOR pathway, PDI, Protein disulfide-isomerase, PI3K, phosphoinositide (PI) 3-kinase, S6K, S6 kinase, Gene Expression Profiling, Hematopoietic Stem Cells, medicine.disease, Disease Models, Animal, Rapamycin-Insensitive Companion of mTOR Protein, 030104 developmental biology, Cutaneous melanoma, Cancer cell, Cancer research, Hepatic stellate cell, HGF, hepatocyte growth factor, FCS, fetal calf serum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29f172098b8464f3ec60037df097799
https://www.ncbi.nlm.nih.gov/pubmed/30404068

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المؤلفون: Aurelio Galli, Olga I. Dadalko, Kevin D. Niswender

المصدر: Heliyon, Vol 1, Iss 1 (2015)
Heliyon

مصطلحات موضوعية: medicine.medical_specialty, Dopamine, Biology, Neurotransmission, Article, AMPH, Amphetamine, Rictor, Internal medicine, medicine, Obesity, lcsh:Social sciences (General), Amphetamine, lcsh:Science (General), mTORC2, Catecholaminergic, mTORC2, mammalian Target Of Rapamycin Complex 2, Multidisciplinary, Tyrosine hydroxylase, DA, Dopamine, High fat diet, digestive, oral, and skin physiology, LF, Low fat, Insulin receptor, Endocrinology, biology.protein, HF, High fat, Catecholaminergic cell groups, lcsh:H1-99, Homeostasis, medicine.drug, lcsh:Q1-390

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a23a51356e6d84161724ba4207c062

المؤلفون: Danielpour D; Case Comprehensive Cancer Center Research Laboratories, The Division of General Medical Sciences-Oncology Case Western Reserve University, Cleveland, OH, 44106, USA.; Department of Pharmacology Case Western Reserve University, Cleveland, OH, 44106, USA.; Department of Urology University Hospitals of Cleveland, Cleveland, OH, 44106, USA., Corum S; Case Comprehensive Cancer Center Research Laboratories, The Division of General Medical Sciences-Oncology Case Western Reserve University, Cleveland, OH, 44106, USA., Leahy P; Case Comprehensive Cancer Center Research Laboratories, The Division of General Medical Sciences-Oncology Case Western Reserve University, Cleveland, OH, 44106, USA., Bangalore A; Case Comprehensive Cancer Center Research Laboratories, The Division of General Medical Sciences-Oncology Case Western Reserve University, Cleveland, OH, 44106, USA.

المصدر: Current research in pharmacology and drug discovery [Curr Res Pharmacol Drug Discov] 2022 Jul 04; Vol. 3, pp. 100117. Date of Electronic Publication: 2022 Jul 04 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918300982506676 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-2571 (Electronic) Linking ISSN: 25902571 NLM ISO Abbreviation: Curr Res Pharmacol Drug Discov Subsets: PubMed not MEDLINE

المؤلفون: Tang H; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wu K; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wang J; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Vinjamuri S; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Gu Y; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Song S; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Wang Z; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhang Q; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona., Balistrieri A; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Ayon RJ; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Rischard F; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Vanderpool R; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Chen J; Department of Pediatrics, University of Illinois College of Medicine, Chicago, Illinois., Zhou G; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Department of Pediatrics, University of Illinois College of Medicine, Chicago, Illinois., Desai AA; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; Division of Cardiology, Department of Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Black SM; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona., Garcia JGN; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona.; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The University of Arizona College of Medicine, Tucson, Arizona., Yuan JX; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona., Makino A; Division of Translational and Regenerative Medicine, The University of Arizona College of Medicine, Tucson, Arizona.; Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona.

المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Dec 31; Vol. 3 (6), pp. 744-762. Date of Electronic Publication: 2018 Dec 31 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE

المؤلفون: Basnet R; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Gong GQ; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Li C; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Wang MW; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmacy, Fudan University, Shanghai 201203, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2018 Sep; Vol. 8 (5), pp. 767-771. Date of Electronic Publication: 2018 Jul 05.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE

المؤلفون: Dadalko OI; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA; Neuroscience Program in Substance Abuse, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA., Niswender K; Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA; TN Valley Healthcare System, Nashville, TN 37212, USA., Galli A; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA; Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA; Neuroscience Program in Substance Abuse, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA.

المصدر: Heliyon [Heliyon] 2015 Sep 21; Vol. 1 (1), pp. e00025. Date of Electronic Publication: 2015 Sep 21 (Print Publication: 2015).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE