المؤلفون: Xiaolin Ni, Huabin Su, Yuan Lv, Rongqiao Li, Chen Chen, Di Zhang, Qing Chen, Shenqi Zhang, Ze Yang, Liang Sun, Qi Zhou, Xiaoquan Zhu, Danni Gao, Sihang Fang, Caiyou Hu, Guofang Pang, Huiping Yuan

المصدر: Frontiers in Psychiatry, Vol 13 (2022)

مصطلحات موضوعية: epidemiology, cross-sectional study, depression, major risk factor, chronic pain, Psychiatry, RC435-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.986389/full; https://doaj.org/toc/1664-0640

URL الوصول: https://doaj.org/article/5734ac1a75ba42158d7439d3e0d6818e

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Trofe, Jennifer^Aff10, Buell, Joseph F.^Aff10, First, M. Roy^Aff10, Hanaway, Michael J.^Aff10, Beebe, Tom M.^Aff10, Woodle, E. Steve^Aff10

المساهمون: Schlag, P. M., editor^Aff1, Senn, H.-J., editor^Aff2, Diehl, V., editor^Aff3, Parkin, D. M., editor^Aff4, Rajewsky, M. F., editor^Aff5, Rubens, R., editor^Aff6, Wannenmacher, M., editor^Aff7, Rentchnik, P., editor^Aff8, Oertel, Stephan H., editor^Aff9, Riess, Hanno, editor^Aff9

المصدر: Immunosurveillance, Immunodeficiencies and Lymphoproliferations : Lymphoproliferative Disorders in Congenital and Acquired Immunodeficiencies. 159:55-66

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Andrea Strianese, Ornella Moltedo, Giuseppe Giugliano, Fausto Acernese, Valentina Trimarco, Paola Di Pietro, Ornella Piazza, Serena Migliarino, Antonio D'Amato, Carmine Vecchione, Marco Oliveti, Bruno Trimarco, Annibale Alessandro Puca, Carmine Izzo, Raffaele Izzo, Katiuscia Martinello, Pietro Campiglia, Nicola Virtuoso, Eduardo Sommella, Sergio Fucile, Albino Carrizzo

المساهمون: Carrizzo, A., Moltedo, O., Damato, A., Martinello, K., Di Pietro, P., Oliveti, M., Acernese, F., Giugliano, G., Izzo, R., Sommella, E., Migliarino, S., Piazza, O., Izzo, C., Virtuoso, N., Strianese, A., Trimarco, V., Campiglia, P., Fucile, S., Puca, A., Trimarco, B., Vecchione, C.

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

مصطلحات موضوعية: Male, AkP05 reduced BP and improved endothelial function, Disease, 030204 cardiovascular system & hematology, Camellia sinensis, chemistry.chemical_compound, and end-organ damage. However, Mice, 0302 clinical medicine, endothelial function, cardiovascular disease, Medicine, Stroke, Original Research, 0303 health sciences, Exercise Tolerance, and circulating nitric oxide were assessed before and at the end of 4 weeks of treatment. Twenty-four patients were randomized to diuretic or AkP05 for 4 weeks and underwent a cardiopulmonary exercise test to evaluate the effects of AkP05 on functional capacity of the cardiovascular, Exercise capacity, Middle Aged, Background-—High blood pressure (BP) has long been recognized as a major health threat and, exercise capacity, and muscular systems. Vascular and molecular studies were undertaken on mice to characterize the action of the single compounds contained in the AkP05 nutraceutical combination. AkP05 supplementation reduced BP, cardiopulmonary exercise test revealed that AkP05 increased maximum O2 uptake, Hypertension, Cardiology, Female, Background-—High blood pressure (BP) has long been recognized as a major health threat and, particularly, a major risk factor for stroke, cardiovascular disease, and end-organ damage. However, the identification of a novel, alternative, integrative approach for the control of BP and cardiovascular protection is still needed. Methods and Results-—Sixty-nine uncontrolled hypertension patients, aged 40 to 68 years, on antihypertensive medication were enrolled in 2 double-blind studies. Forty-five were randomized to placebo or a new nutraceutical combination named AkP05, and BP, endothelial function, and circulating nitric oxide were assessed before and at the end of 4 weeks of treatment. Twenty-four patients were randomized to diuretic or AkP05 for 4 weeks and underwent a cardiopulmonary exercise test to evaluate the effects of AkP05 on functional capacity of the cardiovascular, pulmonary, and muscular systems. Vascular and molecular studies were undertaken on mice to characterize the action of the single compounds contained in the AkP05 nutraceutical combination. AkP05 supplementation reduced BP, improved endothelial function, and increased nitric oxide release, cardiopulmonary exercise test revealed that AkP05 increased maximum O2 uptake, stress tolerance, and maximal power output. In mice, AkP05 reduced BP and improved endothelial function, evoking increased nitric oxide release through the PKCa/Akt/endothelial nitric oxide synthase pathway and reducing reactive oxygen species production via NADPH-oxidase inhibition. These effects were mediated by synergism of the single compounds of AkP05. Conclusions-—This is the first study reporting positive effects of a nutraceutical combination on the vasculature and exercise tolerance in treated hypertensive patients. Our findings suggest that AkP05 may be used as an adjunct for the improvement of cardiovascular protection and to better control BP in uncontrolled hypertension, Cardiology and Cardiovascular Medicine, evoking increased nitric oxide release through the PKCa/Akt/endothelial nitric oxide synthase pathway and reducing reactive oxygen species production via NADPH-oxidase inhibition. These effects were mediated by synergism of the single compounds of AkP05. Conclusions-—This is the first study reporting positive effects of a nutraceutical combination on the vasculature and exercise tolerance in treated hypertensive patients. Our findings suggest that AkP05 may be used as an adjunct for the improvement of cardiovascular protection and to better control BP in uncontrolled hypertension, integrative approach for the control of BP and cardiovascular protection is still needed. Methods and Results-—Sixty-nine uncontrolled hypertension patients, particularly, alternative, Adult, medicine.medical_specialty, pulmonary, on antihypertensive medication were enrolled in 2 double-blind studies. Forty-five were randomized to placebo or a new nutraceutical combination named AkP05, Phosphatidylserines, Nitric Oxide, Nitric oxide, 03 medical and health sciences, Nutraceutical, Double-Blind Method, Internal medicine, Animals, Humans, a major risk factor for stroke, and BP, Risk factor, aged 40 to 68 years, and maximal power output. In mice, 030304 developmental biology, Aged, stress tolerance, business.industry, Mechanism (biology), and increased nitric oxide release, Ginkgo biloba, vascular biology, medicine.disease, nitric oxide, improved endothelial function, Blood pressure, chemistry, Dietary Supplements, Exercise Test, Bacopa, Plant Preparations, the identification of a novel, business, Reactive Oxygen Species, Phytotherapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e8335ac991dabbb0760a81cf9188c4
https://pubmed.ncbi.nlm.nih.gov/32078787

المؤلفون: Young, Sarah^Aff1, Rhodes, Paul, Touyz, Stephen, Arcelus, Jon, Meyer, Caroline, Pike, Kathleen, Madden, Sloane, Crosby, Ross, Attia, Evelyn, Clemes, Stacy, Hay, Phillipa

المصدر: Journal of Eating Disorders. 3(Suppl 1)

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Ames, B. N.^Aff5, Hagen, T. M.^Aff5, Shigenaga, M. K.^Aff5

المساهمون: Nigam, Santosh, editor^Aff1, Honn, Kenneth V., editor^Aff2, Marnett, Lawrence J., editor^Aff3, Walden, Thomas L., Jr., editor^Aff4

المصدر: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury : Proceedings of the 2nd International Conference September 17–21, 1991 Berlin, FRG. 71:383-385

المؤلفون: Roy, C.^Aff1_64, Roque, J. L.^Aff1_64, Francois, P. M.^Aff1_64, Ferrieres, A.^Aff1_64, Raboisson, D.^Aff2_64

المساهمون: Hogeveen, H., editor^Aff1, Lam, T. J. G. M., editor^Aff1

المصدر: Udder Health and Communication. :346-346