المؤلفون: Avarlaid A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia. Electronic address: annela.avarlaid@taltech.ee., Falkenberg K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Lehe K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Mudò G; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Belluardo N; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Di Liberto V; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Frinchi M; Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia. Electronic address: tonis.timmusk@taltech.ee.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jun; Vol. 300 (6), pp. 107411. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor*/metabolism , Brain-Derived Neurotrophic Factor*/genetics , MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Hippocampus*/metabolism , Hippocampus*/cytology , Neurons*/metabolism , Neurons*/cytology , Enhancer Elements, Genetic*, Animals ; Rats ; Cerebral Cortex/metabolism ; Cerebral Cortex/cytology ; Gene Expression Regulation ; Cells, Cultured ; Rats, Sprague-Dawley

المؤلفون: Chinellato M; Department of Biology, University of Padua, Via U. Bassi 58, 35131 Padova, Italy., Perin S; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy., Carli A; Department of Biology, University of Padua, Via U. Bassi 58, 35131 Padova, Italy., Lastella L; Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padova, Italy., Biondi B; Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padova, Italy., Borsato G; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy., Di Giorgio E; Department of Medicine, Università Degli Studi di Udine, P.le Kolbe 4, 33100 Udine, Italy., Brancolini C; Department of Medicine, Università Degli Studi di Udine, P.le Kolbe 4, 33100 Udine, Italy., Cendron L; Department of Biology, University of Padua, Via U. Bassi 58, 35131 Padova, Italy. Electronic address: laura.cendron@unipd.it., Angelini A; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy; European Centre for Living Technology (ECLT), Ca' Bottacin, Dorsoduro 3911, Calle Crosera, 30123 Venice, Italy. Electronic address: alessandro.angelini@unive.it.

المصدر: Journal of molecular biology [J Mol Biol] 2024 May 01; Vol. 436 (9), pp. 168541. Date of Electronic Publication: 2024 Mar 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: DNA*/metabolism , DNA*/chemistry , Histone Deacetylases*/chemistry , Histone Deacetylases*/metabolism , MEF2 Transcription Factors*/chemistry , MEF2 Transcription Factors*/metabolism , Peptides*/chemistry , Peptides*/metabolism, Humans ; Amino Acid Sequence ; Crystallography, X-Ray ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Folding

المؤلفون: Gao C; Department of Pharmacology and Systems Physiology, University of Cincinnati, OH (C.G.)., Wang Y; Signature Research Program in Cardiovascular and Metabolic Diseases, DukeNUS Medical School, Singapore (Y.W.).; National Heart Center of Singapore and Institute of Cell and Molecular Biology, A'STAR, Singapore (Y.W.).

المصدر: Circulation research [Circ Res] 2024 Jul 19; Vol. 135 (3), pp. 450-452. Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article; Editorial; Comment

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomegaly*/metabolism , Cardiomegaly*/genetics , NFATC Transcription Factors*/metabolism , NFATC Transcription Factors*/genetics , MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics, Humans ; Animals ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Myocytes, Cardiac/metabolism

المؤلفون: Szeto ACH; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Clark PA; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Ferreira ACF; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Heycock M; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Griffiths EL; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Jou E; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Mannion J; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Luan SL; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Storrar S; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Knolle MD; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.; Cambridge University Hospitals, Cambridge, CB2 0QQ, UK., Kozik P; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Jolin HE; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Fallon PG; School of Medicine, Trinity College Dublin, Dublin, Ireland., McKenzie ANJ; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

المصدر: Science (New York, N.Y.) [Science] 2024 Jun 28; Vol. 384 (6703), pp. eadl0370. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Th2 Cells*/immunology , Immunity, Innate* , Interleukin-33*/metabolism , NFATC Transcription Factors*/metabolism , Pneumonia*/immunology , GATA3 Transcription Factor*/metabolism , GATA3 Transcription Factor*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Cell Differentiation ; Calcium Signaling ; Hypersensitivity/immunology ; Lung/immunology ; Allergens/immunology ; Lymphocytes/immunology ; Interleukin-1 Receptor-Like 1 Protein

المؤلفون: Wu R; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Sun Y; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Zhou Z; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Dong Z; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Liu Y; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Liu M; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China., Gao H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

المصدر: The European journal of neuroscience [Eur J Neurosci] 2024 Jun; Vol. 59 (12), pp. 3389-3402. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Zebrafish* , MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Kinesins*/metabolism , Kinesins*/genetics , Axons*/metabolism , Axons*/physiology, Animals ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Motor Neurons/metabolism ; Neurogenesis/physiology ; Gene Expression Regulation, Developmental ; Humans

المؤلفون: Zhang Y; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: zhangyingzi@zju.edu.cn., Lin W; Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310020, Zhejiang, China; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China. Electronic address: linwu@zju.edu.cn., Yang Y; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: yangyan1222@zju.edu.cn., Zhu S; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: zzzst978@163.com., Chen Y; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: yiranchen@zju.edu.cn., Wang H; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: lanceter1@zju.edu.cn., Teng L; Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China. Electronic address: lsteng@zju.edu.cn.

المصدر: Cancer letters [Cancer Lett] 2024 Jun 01; Vol. 591, pp. 216878. Date of Electronic Publication: 2024 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/genetics , MEF2 Transcription Factors*/metabolism , Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Interleukin-13*/metabolism , Interleukin-13*/genetics , Gene Expression Regulation, Neoplastic* , Liver Neoplasms*/secondary , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism, Humans ; Animals ; Cell Line, Tumor ; Interleukin-13 Receptor alpha1 Subunit/genetics ; Interleukin-13 Receptor alpha1 Subunit/metabolism ; Promoter Regions, Genetic ; Mice ; Mice, Nude ; beta Catenin/metabolism ; beta Catenin/genetics ; Mice, Inbred BALB C ; Female ; Signal Transduction ; Male ; Up-Regulation

المؤلفون: Ding Y; Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China., Lin M; Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China., Wang J; Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China., Shang X; Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: xiulishangcmu@126.com.

المصدر: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Jun; Vol. 1871 (5), pp. 119738. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Blood-Brain Barrier*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , RNA, Messenger*/metabolism , RNA, Messenger*/genetics , Alzheimer Disease*/metabolism , Alzheimer Disease*/genetics , Alzheimer Disease*/pathology , Zonula Occludens-1 Protein*/metabolism , Zonula Occludens-1 Protein*/genetics , Endothelial Cells*/metabolism, Animals ; Humans ; Occludin/metabolism ; Occludin/genetics ; Mice ; RNA Stability ; Permeability ; Capillary Permeability

المؤلفون: Wang X; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Shen H; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Chen Y; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Zhang Y; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Wang J; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Liu S; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Xu B; Department of Pathology, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Wang H; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Frangou C; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA., Zhang J; Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 10; Vol. 25 (10). Date of Electronic Publication: 2024 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Epithelial-Mesenchymal Transition*/genetics , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Cell Proliferation*/genetics, Animals ; Humans ; Female ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Signal Transduction

المؤلفون: Li JH; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Zhou A; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lee CD; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Shah SN; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Ji JH; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Senthilkumar V; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Padilla ET; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Ball AB; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Feng Q; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Bustillos CG; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Riggan L; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Greige A; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA., Divakaruni AS; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Annese F; Greenwood Genetic Center, Greenwood, SC, USA., Cooley Coleman JA; Greenwood Genetic Center, Greenwood, SC, USA., Skinner SA; Greenwood Genetic Center, Greenwood, SC, USA., Cowan CW; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA., O'Sullivan TE; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. tosullivan@mednet.ucla.edu.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA. tosullivan@mednet.ucla.edu.

المصدر: Nature immunology [Nat Immunol] 2024 May; Vol. 25 (5), pp. 778-789. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/metabolism , MEF2 Transcription Factors*/genetics , Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Lipid Metabolism*, Animals ; Humans ; Mice ; CRISPR-Cas Systems ; Mice, Knockout ; Interleukin-15/metabolism ; Mice, Inbred C57BL

المؤلفون: Menshawy NE; Clinical Pathology, Hematology unit, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., El-Ghonemy MS; Clinical Pathology, Hematology unit, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Ebrahim MA; Medical Oncology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Fahmi MW; Medical Oncology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. marianwaheeb@mans.edu.eg., Saif M; Medical Oncology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., Denewer M; Clinical Hematology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt., El-Ashwah S; Clinical Hematology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.

المصدر: Annals of hematology [Ann Hematol] 2024 Jul; Vol. 103 (7), pp. 2355-2364. Date of Electronic Publication: 2024 May 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/genetics , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/therapy , MDS1 and EVI1 Complex Locus Protein*/genetics , Translocation, Genetic*, Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Chromosomes, Human, Pair 11/genetics ; Prospective Studies ; Young Adult ; Gene Rearrangement ; Adolescent