نتائج البحث - "metabolism [Chromatin]"

1

Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome

المؤلفون: Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack, Stefanie Heidrich, Darren Ó hAilín, Alejandro Villarreal, Christine Hacker, Tudor Rauleac, Chiara Bella, Andre Fischer, Thomas Manke, Tanja Vogel

المصدر: Proceedings of the National Academy of Sciences of the United States of America 120(2), e2122467120 (2023). doi:10.1073/pnas.2122467120
Proceedings of the National Academy of Sciences of the United States of America

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a63bc501a1af10cdc8ad232f77a2ac2
https://pub.dzne.de/record/169280

2

LncRNA RUS shapes the gene expression program towards neurogenesis

المؤلفون: Marius F Schneider, Veronika Müller, Stephan A Müller, Stefan F Lichtenthaler, Peter B Becker, Johanna C Scheuermann

المصدر: Life science alliance 5(10), e202201504 (2022). doi:10.26508/lsa.202201504

مصطلحات موضوعية: Ecology, metabolism [Chromatin], genetics [Mammals], Health, Toxicology and Mutagenesis, metabolism [Mammals], Gene Expression, genetics [RNA, Long Noncoding], Plant Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), Mice, genetics [Chromatin], genetics [Neurogenesis], metabolism [Neurons], ddc:570, metabolism [RNA, Long Noncoding], Animals

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b963c0a1cbc534a97beac63d22ee2c
https://doi.org/10.1101/2022.02.17.480853

3

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress

المؤلفون: Fernando Gómez-Herreros, Philip Van Damme, Marcel Naumann, Duncan A. Q. Moore, María Isabel Martínez-Macías, Ryan L. Green, Majid Hafezparast, Andreas Hermann, Keith W. Caldecott

المساهمون: Instituto de Biomedicina de Sevilla (IBIS), European Research Council, EMBO

المصدر: Life Science Alliance
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Life science alliance 2(2), e201800222 (2019). doi:10.26508/lsa.201800222

مصطلحات موضوعية: Life Sciences & Biomedicine - Other Topics, 0301 basic medicine, DNA Repair, Transcription, Genetic, TDP-43, Nucleolus, Health, Toxicology and Mutagenesis, metabolism [DNA Topoisomerases, Type I], RNA polymerase II, Plant Science, metabolism [Neural Stem Cells], Q1, AMYOTROPHIC-LATERAL-SCLEROSIS, Mice, 0302 clinical medicine, Neural Stem Cells, Transcription (biology), RNA Polymerase I, DNA Breaks, Double-Stranded, TOP1 protein, human, Research Articles, metabolism [RNA-Binding Protein FUS], Neurons, ROLES, Ecology, biology, Chemistry, BINDING PROTEINS, FUS protein, mouse, Brain, metabolism [RNA Polymerase I], Chromatin, 3. Good health, Cell biology, genetics [Amyotrophic Lateral Sclerosis], DNA Topoisomerases, Type I, metabolism [Neurons], metabolism [RNA Polymerase II], COMPLEXES, RNA Polymerase II, Life Sciences & Biomedicine, FUS/TLS, metabolism [Fibroblasts], Research Article, DNA repair, metabolism [Chromatin], INSTABILITY, RNA-POLYMERASE-II, Q0179.9, genetics [Mutation], Biochemistry, Genetics and Molecular Biology (miscellaneous), 03 medical and health sciences, embryology [Brain], ddc:570, RNA polymerase I, Animals, Humans, Binding site, pathology [Amyotrophic Lateral Sclerosis], Biology, SPINOCEREBELLAR ATAXIA, Science & Technology, Binding Sites, MUTATIONS, Topoisomerase, cytology [Brain], Amyotrophic Lateral Sclerosis, Ribosomal RNA, FUS protein, human, Fibroblasts, 030104 developmental biology, A549 Cells, Mutation, biology.protein, RNA-Binding Protein FUS, Mutant Proteins, genetics [RNA-Binding Protein FUS], 030217 neurology & neurosurgery, HeLa Cells

وصف الملف: application/pdf; Electronic-Print

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a997c0650dddf63f90e8dfd173f3753
http://europepmc.org/articles/PMC6391683

4

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

المؤلفون: Giovanna Ambrosini, Ina Schmitt, Ullrich Wüllner, Naoki Osato, Philipp Bucher, Hongde Liu, Tikam Chand Dakal, Amit Sharma, Shailendra Asthana

المصدر: Scientific reports 9(1), 18464 (2019). doi:10.1038/s41598-019-54865-w
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

مصطلحات موضوعية: metabolism [Histones], pathology [Dopaminergic Neurons], genetics [Introns], lcsh:Medicine, Datasets as Topic, Genome-wide association study, Epigenesis, Genetic, Histones, genetics [Parkinson Disease], alpha-synuclein expression, site, metabolism [alpha-Synuclein], lcsh:Science, Epigenomics, Genetics, Multidisciplinary, Epigenetics and plasticity, metabolism [Dopaminergic Neurons], Parkinson Disease, Chromatin, Nucleosomes, Substantia Nigra, metabolism [DNA (Cytosine-5-)-Methyltransferase 1], DNA methylation, alpha-Synuclein, genetics [alpha-Synuclein], genetics [Protein Binding], transcription, Protein Binding, metaanalysis, DNA (Cytosine-5-)-Methyltransferase 1, genetics [Binding Sites], metabolism [Chromatin], Single-nucleotide polymorphism, cytology [Substantia Nigra], Biology, Polymorphism, Single Nucleotide, Article, metabolism [Substantia Nigra], Humans, Genetic Predisposition to Disease, Epigenetics, Gene, metabolism [Nucleosomes], pathology [Substantia Nigra], Genetic association, Binding Sites, promoter, Dopaminergic Neurons, lcsh:R, sequence, DNA Methylation, Introns, pathology [Parkinson Disease], genome-wide association, identification, lcsh:Q, methylation, ddc:600, Neuroscience, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6a32195c571ce4385be42c7fe9b66a

5

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

المصدر: Nature Communications
Nature Communications 10(1), 1262 (2019). doi:10.1038/s41467-019-09140-x
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, metabolism [Histones], Carcinogenesis, metabolism [Polycomb Repressive Complex 2], genetics [Histone Code], General Physics and Astronomy, 02 engineering and technology, Mice, SCID, medicine.disease_cause, genetics [Glioblastoma], Epigenesis, Genetic, pathology [Glioblastoma], Histones, Mice, Methionine, Mice, Inbred NOD, genetics [Carcinogenesis], Histone code, lcsh:Science, Child, Regulation of gene expression, Gene Editing, Multidisciplinary, biology, Brain Neoplasms, Neurogenesis, Polycomb Repressive Complex 2, 021001 nanoscience & nanotechnology, genetics [Histones], Chromatin, 3. Good health, Cell biology, genetics [Methionine], Gene Expression Regulation, Neoplastic, Histone Code, Histone, genetics [Neurogenesis], DNA methylation, Female, ddc:500, 0210 nano-technology, PRC2, methods [Gene Editing], pathology [Brain Neoplasms], Adolescent, metabolism [Chromatin], Science, macromolecular substances, genetics [DNA Methylation], General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, genetics [Lysine], Aged, Cell Proliferation, Lysine, General Chemistry, DNA Methylation, Xenograft Model Antitumor Assays, genetics [Brain Neoplasms], 030104 developmental biology, HEK293 Cells, Mutation, biology.protein, lcsh:Q, CpG Islands, CRISPR-Cas Systems, Glioblastoma, genetics [Cell Proliferation], genetics [CpG Islands]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8009a4766e296bb95581ac15a67e41
https://pubmed.ncbi.nlm.nih.gov/30890717

Find this article in full text from ProQuest

6

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

المصدر: Cancer Cell
Cancer cell 35(5), 782-797.e8 (2019). doi:10.1016/j.ccell.2019.04.004

مصطلحات موضوعية: 0301 basic medicine, Epigenomics, genetics [Glioma], Cancer Research, metabolism [Histones], drug effects [Gene Expression Regulation, Neoplastic], Vulnerability, medicine.disease_cause, metabolism [Glioma], Histones, 0302 clinical medicine, drug therapy [Brain Neoplasms], methods [Epigenomics], therapeutic use [Histone Deacetylase Inhibitors], Mutation, 0303 health sciences, Brain Neoplasms, Acetylation, Glioma, genetics [Histones], Chromatin, Cell biology, metabolism [Brain Neoplasms], 3. Good health, Gene Expression Regulation, Neoplastic, Histone, Enhancer Elements, Genetic, Oncology, Expression (architecture), 030220 oncology & carcinogenesis, metabolism [Chromatin], Biology, Article, 03 medical and health sciences, Cell Line, Tumor, drug therapy [Glioma], medicine, Humans, ddc:610, Enhancer, 030304 developmental biology, Cell Biology, drug effects [Enhancer Elements, Genetic], genetics [Brain Neoplasms], Histone Deacetylase Inhibitors, 030104 developmental biology, DNA demethylation, Cancer cell, biology.protein, Cancer research, Histone deacetylase, pharmacology [Histone Deacetylase Inhibitors]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f6bd293b5e4adacf9e476cd466f7fd
https://pubmed.ncbi.nlm.nih.gov/31526762

7

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

المؤلفون: Mathieu Blanchette, Albert M. Berghuis, Hiromichi Suzuki, Pratiti Bandopadhayay, Dong Anh Khuong-Quang, Dylan M. Marchione, Nicolas De Jay, Wajih Jawhar, Angelia V. Bassenden, Djihad Hadjadj, Ashot S. Harutyunyan, Shriya Deshmukh, Steffen Albrecht, Michele Zeinieh, Nikoleta Juretic, Paolo Salomoni, Katerina Vanova, Ales Vicha, Stefan M. Pfister, Manav Pathania, Selin Jessa, Almos Klekner, Leonie G. Mikael, CM Kramm, David T.W. Jones, Tenzin Gayden, Sebastian Brandner, Michal Zapotocky, Nicola Maestro, Eleanor Woodward, Alexander G. Weil, David S. Ziegler, Jordan R. Hansford, Steven Hébert, Frank Dubois, Benjamin Ellezam, Deli A, Damien Faury, Véronique Lisi, Augusto Faria Andrade, Andrey Korshunov, Mariella G. Filbin, Michael D. Taylor, Claudia L. Kleinman, Andrea Bajic, Carol C.L. Chen, Caterina Russo, Nada Jabado, Peter Hauser, Benjamin A. Garcia, Stephen C. Mack, Keith L. Ligon, David Sumerauer, Lenka Krskova, Jason Karamchandani, Rameen Beroukhim, Rola Dali, László Bognár, Dominik Sturm, József Virga, Marie Coutelier, Livia Garzia, Paul G Ekert, Josef Zamecnik

المصدر: Cell 183(6), 1617-1633.e22 (2020). doi:10.1016/j.cell.2020.11.012
Cell

مصطلحات موضوعية: genetics [Glioma], metabolism [Histones], Receptor, Platelet-Derived Growth Factor alpha, Transcription, Genetic, Carcinogenesis, pathology [Carcinogenesis], genetics [Transcriptome], metabolism [Neural Stem Cells], medicine.disease_cause, Epigenesis, Genetic, Histones, chromatin conformation, 0302 clinical medicine, Neural Stem Cells, genetics [Carcinogenesis], Promoter Regions, Genetic, metabolism [Interneurons], pathology [Astrocytes], 0303 health sciences, Mutation, metabolism [Astrocytes], biology, Brain Neoplasms, cell-of-origin, Glioma, metabolism [Receptor, Platelet-Derived Growth Factor alpha], Cellular Reprogramming, genetics [Histones], metabolism [Lysine], Chromatin, pediatric cancer, Gene Expression Regulation, Neoplastic, Oligodendroglia, genetics [Cellular Reprogramming], PDGFRA, Histone, GSX2, Lineage (genetic), pathology [Brain Neoplasms], interneuron progenitors, metabolism [Chromatin], genetics [Mutation], Context (language use), embryology [Prosencephalon], Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, metabolism [Oligodendroglia], H3.3 G34R/V, 03 medical and health sciences, Histone H3, Prosencephalon, Interneurons, medicine, Animals, Cell Lineage, ddc:610, Gene Silencing, metabolism [Embryo, Mammalian], 030304 developmental biology, Lysine, single-cell transcriptome, Embryo, Mammalian, Pediatric cancer, oncohistones, digestive system diseases, genetics [Receptor, Platelet-Derived Growth Factor alpha], genetics [Brain Neoplasms], Mice, Inbred C57BL, gliomas, Astrocytes, genetics [Promoter Regions, Genetic], biology.protein, Cancer research, Neoplasm Grading, Transcriptome, pathology [Glioma], 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a47ac89beefcaff088e65fd3f8a3589
https://doi.org/10.1016/j.cell.2020.11.012

8

Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants

المؤلفون: Stanimir Dulev, Christelle de Renty, Alexander V. Strunnikov, Etienne Schwob, Rajvi Mehta, Ivan Minkov

المساهمون: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (34), pp.14466--71. ⟨10.1073/pnas.0900190106⟩

مصطلحات موضوعية: Transcription, Genetic, Cell Nucleus Anaphase/genetics Blotting, Essential/genetics/physiology Genome, Cell Cycle Proteins, Eukaryotic DNA replication, Pre-replication complex, S Phase, DNA replication factor CDT1, 0302 clinical medicine, Chromosome Segregation, Replication Protein A, DNA, Fungal, Western Cell Cycle Proteins/*genetics/metabolism Cell Nucleus/metabolism Chromatin Immunoprecipitation Chromosome Segregation Chromosomes, Genetics, 0303 health sciences, Genes, Essential, Multidisciplinary, biology, Biological Sciences, Active Transport, Chromosomes, Fungal, Genome, Fungal, Biological *Mutation Protein Binding Protein Tyrosine Phosphatases/*genetics/metabolism Replication Protein A/genetics/metabolism S Phase/genetics Saccharomyces cerevisiae/genetics/metabolism Saccharomyces cerevisiae Proteins/*genetics/metabolism Transcription, Protein Binding, DNA Replication, DNA re-replication, Chromatin Immunoprecipitation, Saccharomyces cerevisiae Proteins, Blotting, Western, Active Transport, Cell Nucleus, Saccharomyces cerevisiae, DNA, Ribosomal, Models, Biological, Ribosomal/genetics G1 Phase/genetics Genes, 03 medical and health sciences, Replication factor C, Genetic, Control of chromosome duplication, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030304 developmental biology, Cell Nucleus, Fungal/genetics Genome-Wide Association Study Models, Fungal/*biosynthesis/genetics DNA, G1 Phase, Licensing factor, Mutation, biology.protein, Origin recognition complex, Protein Tyrosine Phosphatases, Anaphase, Fungal/*genetics DNA Damage DNA Replication DNA, 030217 neurology & neurosurgery, DNA Damage, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a486436b1b47cc3ed1971fa298efc52
https://doi.org/10.1073/pnas.0900190106

9

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

المؤلفون: Jean Gautier, Karlene A. Cimprich, David Shechter, Vincenzo Costanzo, Patrick J. Lupardus, Max E. Gottesman

المساهمون: Costanzo, Vincenzo, D., Shechter, P. J., Lupardu, K. A., Cimprich, M., Gottesman, J., Gautier

المصدر: Molecular Cell. 11:203-213

مصطلحات موضوعية: Exonucleases, Male, metabolism, Humans, Macromolecular Substances, Male, Nucleic Acid Synthesis Inhibitor, Cell Cycle Proteins, Eukaryotic DNA replication, Ataxia Telangiectasia Mutated Proteins, Xenopus Proteins, Xenopus laevis, drug effects/genetics/metabolism, Enzyme Inhibitor, Enzyme Inhibitors, Etoposide, pharmacology, Cell Cycle Protein, metabolism, Protein-Serine-Threonine Kinase, Spermatozoa, pharmacology, Caffeine, Chromatin, Signal Transduction, cytology/physiology, Xenopus Proteins, Xenopus laevi, DNA Replication, pharmacology, Etoposide, Macromolecular Substances, DNA damage, DNA repair, DNA polymerase II, Protein Serine-Threonine Kinases, Biology, metabolism, DNA Damage, DNA Replication, DNA, Aphidicolin, Caffeine, Animals, Humans, CHEK1, Molecular Biology, Replication protein A, Nucleic Acid Synthesis Inhibitors, pharmacology, Exonuclease, DNA replication, physiology, Phosphoprotein, DNA, Cell Biology, G2-M DNA damage checkpoint, Phosphoproteins, Animals, Aphidicolin, Molecular biology, physiology, Oocytes, pharmacology, Oocyte, physiology, Spermatozoa, biology.protein, metabolism, Chromatin, metabolism, Signal Transduction, DNA Damage

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceea9dbb836666420bb568539a0f097
https://doi.org/10.1016/s1097-2765(02)00799-2

View record from ScienceDirect

10

Inhibition of Histone Deacetylases Alters Allelic Chromatin Conformation at the Imprinted U2af1-rs1 Locus in Mouse Embryonic Stem Cells

المؤلفون: Sanjeev Khosla, Tamzin E. Randall, Bryan M. Turner, Robert Feil, Laura P. O'Neill, Cécile Fournier, Richard I. Gregory

المساهمون: Environnement et Grandes Cultures (EGC), Institut National de la Recherche Agronomique (INRA)-Institut National Agronomique Paris-Grignon (INA P-G), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: J Biol Chem
J Biol Chem, 2002, 277 (14), pp.11728--34. ⟨10.1074/jbc.M105775200 M105775200 [pii]⟩
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (14), pp.11728--34. ⟨10.1074/jbc.M105775200⟩

مصطلحات موضوعية: Male, Time Factors, Northern Blotting, Protein Conformation, Lysine, Hydroxamic Acids, Kidney, Polymerase Chain Reaction, Biochemistry, Histones, Single-Stranded Conformational Precipitin Tests Protein Conformation Proteins/*genetics Reverse Transcriptase Polymerase Chain Reaction *Ribonucleoproteins Stem Cells/*metabolism Time Factors Tissue Distribution, Mice, 0302 clinical medicine, Mammalian/*cytology Enzyme Inhibitors/*pharmacology Female Fibroblasts/metabolism *Genomic Imprinting *Histone Deacetylase Inhibitors Histones/metabolism Hydroxamic Acids/pharmacology Kidney/metabolism Lysine/chemistry Male Mice Mice, Tissue Distribution, Enzyme Inhibitors, Polymorphism, Single-Stranded Conformational, Acetylation Alleles Animals Blotting, 0303 health sciences, Deoxyribonucleases, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Nuclear Proteins, Acetylation, Cell Differentiation, Chromatin, Blotting, Southern, Histone, Ribonucleoproteins, DNA methylation, Female, Southern Cell Differentiation Cell Nucleus/metabolism Chromatin/*chemistry/metabolism DNA Methylation Deoxyribonuclease I/metabolism Deoxyribonucleases/metabolism Embryo, Molecular Sequence Data, Nerve Tissue Proteins, Biology, Genomic Imprinting, 03 medical and health sciences, Inbred C57BL Molecular Sequence Data *Nerve Tissue Proteins *Nuclear Proteins Polymerase Chain Reaction Polymorphism, Animals, Deoxyribonuclease I, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, Alleles, 030304 developmental biology, Cell Nucleus, Proteins, Cell Biology, DNA Methylation, Fibroblasts, Blotting, Northern, Embryo, Mammalian, Splicing Factor U2AF, Precipitin Tests, Embryonic stem cell, Molecular biology, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, Differentially methylated regions, biology.protein, Genomic imprinting, Chromatin immunoprecipitation, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d779eb0c42ccd938df65fad892b2bb78
https://doi.org/10.1074/jbc.m105775200

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