المؤلفون: Zhu Y; Department of Microbial Testing, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Feng Z; Department of Microbial Testing, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China., Xu Y; Department of Infectious Diseases, the Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China., Luo S; The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Zhang R; The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Shi X; The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Wu X; The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Zhang H; Department of Microbial Testing, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.

المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Jun 13; Vol. 14, pp. 1349063. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , Nucleic Acid Amplification Techniques*/methods , Sensitivity and Specificity* , Molecular Diagnostic Techniques*/methods , Sputum*/microbiology , Tuberculosis, Pulmonary*/diagnosis , Tuberculosis, Pulmonary*/microbiology, Humans ; DNA Primers/genetics ; Female ; Fluorescence ; Adult ; Male ; Tuberculosis/diagnosis ; Tuberculosis/microbiology ; Middle Aged

SCR Protocol: LAMP assay

المؤلفون: Shi Z; Department of Cancer, Hospital of Huainan Eastern Hospital Group, Huainan, 232035, China., Zhou L; Department of Cancer, Hospital of Huainan Eastern Hospital Group, Huainan, 232035, China., Wang X; Department of Pathogen Biology, School of Medicine, Anhui University of Science and Technology, Huainan, 232001, China. wxcvieri@126.com., Zhang Z; Department of Pathogen Biology, School of Medicine, Anhui University of Science and Technology, Huainan, 232001, China., Kong L; Department of Pathogen Biology, School of Medicine, Anhui University of Science and Technology, Huainan, 232001, China., Zhang Y; Department of Cosmetology, College of Medicine, Huainan Union University, Huainan, 232001, China.

المصدر: Archives of microbiology [Arch Microbiol] 2024 Jul 16; Vol. 206 (8), pp. 352. Date of Electronic Publication: 2024 Jul 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/genetics , Th1 Cells*/immunology , Tuberculosis Vaccines*/immunology , Tuberculosis Vaccines*/genetics , Tuberculosis Vaccines*/administration & dosage , Tuberculosis*/immunology , Tuberculosis*/prevention & control , Tuberculosis*/microbiology, Animals ; Mice ; Humans ; Female ; Antigens, Bacterial/immunology ; Antigens, Bacterial/genetics ; Cytokines/metabolism ; Cytokines/immunology ; Bacterial Proteins/immunology ; Bacterial Proteins/genetics ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Mice, Inbred BALB C ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Adjuvants, Immunologic/administration & dosage ; Adult

المؤلفون: Han JH; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea., Kim DY; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea., Lee SY; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea., Park HH; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea. Electronic address: xrayleox@cau.ac.kr.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 12; Vol. 717, pp. 150040. Date of Electronic Publication: 2024 May 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/metabolism , Antigens, Bacterial*/chemistry , Antigens, Bacterial*/immunology , Bacterial Proteins*/chemistry , Bacterial Proteins*/immunology , Bacterial Proteins*/metabolism, Models, Molecular ; Molecular Weight ; Amino Acid Sequence ; Protein Conformation ; Humans

المؤلفون: Xander C; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Rajagopalan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Jacobs WR Jr; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Braunstein M; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.

المصدر: Infection and immunity [Infect Immun] 2024 Jul 11; Vol. 92 (7), pp. e0021724. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Phagosomes*/microbiology , Phagosomes*/metabolism , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Mycobacterium bovis*/genetics , Mycobacterium bovis*/metabolism, Macrophages/microbiology ; Macrophages/immunology ; Macrophages/metabolism ; Humans ; Phosphoric Monoester Hydrolases/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Animals ; Mice

المؤلفون: Asare KK; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. kwame.asare@ucc.edu.gh.; Department of Biomedical Sciences, School of Allied Health Sciences, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. kwame.asare@ucc.edu.gh., Azumah DE; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Adu-Gyamfi CO; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana., Opoku YK; Department of Biology Education, Faculty of Science Education, University of Education, Winneba, Ghana., Adela EM; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Afful P; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana., Abotsi GK; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana., Abban EA; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Duntu PE; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.; Department of Medical Laboratory Science, School of Allied Health Sciences, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana., Anyamful A; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.; Department of Medical Biochemistry, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana., Moses AB; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Botchway E; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Mwintige P; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana., Kyei S; Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.; Department of Optometry and Vision Science, University of Cape Coast, Cape Coast, Ghana., Amoah LE; Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Ekuman EO; Laboratory Departments, Cape Coast Teaching Hospital, Cape Coast, Ghana.

المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Jul 02; Vol. 24 (1), pp. 660. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/isolation & purification , Mycobacterium tuberculosis*/genetics , Sputum*/microbiology , Hospitals, Teaching* , Microscopy*/methods , Tuberculosis, Pulmonary*/diagnosis , Tuberculosis, Pulmonary*/microbiology, Humans ; Retrospective Studies ; Ghana/epidemiology ; Female ; Adult ; Male ; Middle Aged ; Young Adult ; Adolescent ; Sensitivity and Specificity ; Aged ; Molecular Diagnostic Techniques/methods ; Child ; Child, Preschool

المؤلفون: Sun Q; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, PR China., Yan J; Department of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, PR China., Long S; Department of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, PR China., Shi Y; Department of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, PR China., Jiang G; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, PR China., Li H; College of Veterinary Medicine, China Agricultural University, Beijing, PR China.; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, PR China., Huang H; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, PR China., Wang G; Department of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, PR China.

المصدر: Journal of medical microbiology [J Med Microbiol] 2024 Jul; Vol. 73 (7).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Nebramycin*/analogs & derivatives , Nebramycin*/pharmacology , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/genetics , Microbial Sensitivity Tests* , Antitubercular Agents*/pharmacology, Humans ; Tuberculosis, Multidrug-Resistant/microbiology ; Drug Resistance, Multiple, Bacterial

المؤلفون: Park J; Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea., Cheon YJ; Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea., Jeong YC; Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea., Lee KS; Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea.

المصدر: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Jul 01; Vol. 80 (Pt 7), pp. 135-141. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-230X (Electronic) Linking ISSN: 2053230X NLM ISO Abbreviation: Acta Crystallogr F Struct Biol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/chemistry , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics, Crystallography, X-Ray ; Ligands ; Protein Binding ; Protein Domains ; Crystallization ; X-Ray Diffraction ; Escherichia coli/metabolism ; Escherichia coli/genetics ; Cloning, Molecular ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/genetics ; Amino Acid Sequence

المؤلفون: Savanagouder M; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India., Mukku RP; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India., Kiran U; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India.; Academy of Scientific and Innovative Research, Ghaziabad, India., Yeruva CV; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India., Nagarajan N; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India., Sharma Y; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India., Raghunand TR; CSIR - Centre for Cellular and Molecular Biology, Hyderabad, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.

المصدر: FEBS letters [FEBS Lett] 2024 Jul; Vol. 598 (13), pp. 1620-1632. Date of Electronic Publication: 2024 May 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/genetics , Calcium*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Cell Wall*/metabolism , Cell Wall*/genetics, Mycobacterium smegmatis/metabolism ; Mycobacterium smegmatis/genetics ; Mutation ; Protein Binding ; Mycolic Acids/metabolism

المؤلفون: Guo F; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: 2032268928@qq.com., Wei J; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: 20211001010@stu.bbmc.edu.cn., Song Y; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: AYamSong@163.com., Song J; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: scaryface52@163.com., Wang Y; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: 2030595010@qq.com., Li K; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: 2898872675@qq.com., Li B; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China; Department of Clinical Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China. Electronic address: baiqingli@bbmc.edu.cn., Qian Z; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China; Department of Clinical Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China. Electronic address: qzq7778@bbmc.edu.cn., Wang X; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China. Electronic address: wangxiaojing8888@163.com., Wang H; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China; Department of Immunology, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Department of Laboratory Medicine and Rehabilitation, College of Xinjiang Uyghur Medicine, Hetian 848000, China. Electronic address: hongtaowang@bbmc.edu.cn., Xu T; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Molecular Diagnosis Center, First Affiliated Hospital of Bengbu Medical University, China; Department of Clinical Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China. Electronic address: taoxu@bbmc.edu.cn.

المصدر: Cytokine [Cytokine] 2024 Jul; Vol. 179, pp. 156610. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

مواضيع طبية MeSH: Antigens, Bacterial*/immunology , Antigens, Bacterial*/administration & dosage , Cytokines*/metabolism , Mycobacterium tuberculosis*/immunology, Animals ; Mice ; Mycobacterium bovis/immunology ; BCG Vaccine/immunology ; Female ; Mice, Inbred BALB C ; Immunization/methods ; Cell Proliferation/drug effects ; Spleen/immunology

المؤلفون: Dekhil N; Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia., Mardassi H; Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia. Electronic address: helmi.mardassi@mesrs.tn.

المصدر: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jul; Vol. 144, pp. 107077. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/drug effects , Tuberculosis, Multidrug-Resistant*/epidemiology , Tuberculosis, Multidrug-Resistant*/microbiology , Tuberculosis, Multidrug-Resistant*/transmission , Disease Outbreaks* , Whole Genome Sequencing*, Humans ; Tunisia/epidemiology ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Bayes Theorem ; Phylogeny ; Drug Resistance, Multiple, Bacterial/genetics ; Evolution, Molecular ; Male ; Genome, Bacterial ; Female ; Adult ; Microbial Sensitivity Tests ; Genotype