المؤلفون: Ishimoto AK; Mayo Clinic Alix School of Medicine, 13400 E. Shea Blvd, Scottsdale, AZ 85259, United States of America. Electronic address: ishimoto.alyssa@mayo.edu., Shah AA; Mayo Clinic, Division of Community Internal Medicine, Department of Internal Medicine, 13400 E. Shea Blvd, Scottsdale, AZ 85259, United States of America. Electronic address: shah.amit@mayo.edu.

المصدر: Maturitas [Maturitas] 2024 Sep; Vol. 187, pp. 108044. Date of Electronic Publication: 2024 Jun 07.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Ireland NLM ID: 7807333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4111 (Electronic) Linking ISSN: 03785122 NLM ISO Abbreviation: Maturitas Subsets: MEDLINE

مواضيع طبية MeSH: Osteoporosis*/diagnosis , Osteoporosis*/etiology , Osteoporotic Fractures*/prevention & control , Osteoporotic Fractures*/etiology, Humans ; Female ; Middle Aged ; Mass Screening/methods ; Risk Factors ; Age Factors ; Osteoporosis, Postmenopausal

المؤلفون: Zhao Y; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.; Department of Orthopedic surgery, The Fifth Hospital of Harbin, Harbin, Heilongjiang, 150036, China., Liu J; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China., Zhang Y; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China., Liang M; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China., Li R; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.; Spinal Surgery Department, BinZhou Medical University Hospital, Binzhou, Shandong, 256603, China., Song Y; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.; The LiWan Central Hospital of Guang Zhou, Guangzhou, Guangdong, 510000, China., Wang Y; Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, No.23, Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China. wangyansong_w@126.com.

المصدر: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2024 Aug 17; Vol. 19 (1), pp. 480. Date of Electronic Publication: 2024 Aug 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation* , Kruppel-Like Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/metabolism , MicroRNAs*/genetics , Osteogenesis*/genetics , Osteogenesis*/physiology , Osteoporosis, Postmenopausal*/genetics , Osteoporosis, Postmenopausal*/metabolism , Ovariectomy*/adverse effects , Wnt Signaling Pathway*/physiology , Wnt Signaling Pathway*/genetics, Animals ; Female ; Humans ; Rats ; Cells, Cultured ; Disease Models, Animal ; Mesenchymal Stem Cells/metabolism ; Osteoblasts/metabolism ; Osteoporosis/genetics ; Osteoporosis/etiology ; Osteoporosis/metabolism ; Rats, Sprague-Dawley

المؤلفون: Shang G; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Zhou X; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Yin J; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Niu X; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Zhao Y; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Li X; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Tong Q; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Bao B; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Cao Y; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Cheng F; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China., Li Z; Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210009, PR China. Electronic address: lizhipeng@njmu.edu.cn., Yao W; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: yaowf@njucm.edu.cn.

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Aug 15; Vol. 246, pp. 116211. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Bone Marrow*/drug effects , Bone Marrow*/metabolism , Kidney*/drug effects , Kidney*/metabolism , Proteomics*/methods , Rats, Sprague-Dawley* , Ovariectomy* , Metabolomics*/methods , Yin Deficiency*/drug therapy , Osteoporosis*/drug therapy , Osteoporosis*/metabolism, Animals ; Female ; Rats ; Bone and Bones/metabolism ; Bone and Bones/drug effects ; Disease Models, Animal ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/metabolism ; X-Ray Microtomography/methods ; Medicine, Chinese Traditional/methods ; Multiomics

المؤلفون: Shen X; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Chen Y; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Zhang J; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Yang M; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Huang L; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Luo J; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Xu L; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.

المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Aug 08; Vol. 15, pp. 1388717. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).

نوع المنشور: Meta-Analysis; Systematic Review

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

مواضيع طبية MeSH: Fibronectins*/blood , Osteoporosis*/blood , Osteoporosis*/diagnosis, Female ; Humans ; Biomarkers/blood ; Bone Density ; Observational Studies as Topic ; Osteoporosis, Postmenopausal/blood

المؤلفون: Ruiz-Lozano R; Departmento de Ingeniería Mecánica y Fabricación, Universidad de Sevilla, 41092, Seville, Spain., Calvo-Gallego JL; Departmento de Ingeniería Mecánica y Fabricación, Universidad de Sevilla, 41092, Seville, Spain., Pivonka P; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, 4000, Australia., McDonald MM; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Martínez-Reina J; Departmento de Ingeniería Mecánica y Fabricación, Universidad de Sevilla, 41092, Seville, Spain. jmreina@us.es.

المصدر: Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2024 Aug; Vol. 23 (4), pp. 1393-1409. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101135325 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1617-7940 (Electronic) Linking ISSN: 16177940 NLM ISO Abbreviation: Biomech Model Mechanobiol Subsets: MEDLINE

مواضيع طبية MeSH: Aging* , Computer Simulation* , Osteoporosis*, Humans ; Female ; Male ; Postmenopause/physiology ; Models, Biological ; Signal Transduction ; Middle Aged ; RANK Ligand/metabolism ; Aged ; Estrogens/metabolism ; Osteoporosis, Postmenopausal/physiopathology ; Transforming Growth Factor beta/metabolism

المؤلفون: Jones AR; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.; Department of Endocrinology, Monash Health, Melbourne, VIC, Australia., Enticott J; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia., Ebeling PR; Department of Endocrinology, Monash Health, Melbourne, VIC, Australia.; Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia., Mishra GD; Australian Women and Girls' Health Research Centre, School of Public Health, University of Queensland, Brisbane, QLD, Australia., Teede HT; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.; Department of Endocrinology, Monash Health, Melbourne, VIC, Australia., Vincent AJ; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.; Department of Endocrinology, Monash Health, Melbourne, VIC, Australia.

المصدر: Human reproduction (Oxford, England) [Hum Reprod] 2024 May 02; Vol. 39 (5), pp. 1013-1022.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE

مواضيع طبية MeSH: Primary Ovarian Insufficiency*/epidemiology , Menopause, Premature* , Bone Density* , Osteoporosis*/epidemiology , Osteoporosis*/complications , Osteoporosis*/drug therapy, Humans ; Female ; Middle Aged ; Longitudinal Studies ; Adult ; Aged ; Australia/epidemiology ; Absorptiometry, Photon ; Risk Factors ; Fractures, Bone/epidemiology ; Fractures, Bone/etiology ; Prevalence ; Prospective Studies ; Osteoporosis, Postmenopausal/epidemiology ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/drug therapy

المؤلفون: Cohen A; Division of Endocrinology, Department of Medicine, Columbia University, College of Physicians & Surgeons, 180 Fort Washington Avenue, HP9-910, New York, NY 10032, USA. Electronic address: ac1044@columbia.edu.

المصدر: Endocrinology and metabolism clinics of North America [Endocrinol Metab Clin North Am] 2024 Sep; Vol. 53 (3), pp. 453-470. Date of Electronic Publication: 2024 Jun 24.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8800104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-4410 (Electronic) Linking ISSN: 08898529 NLM ISO Abbreviation: Endocrinol Metab Clin North Am Subsets: MEDLINE

مواضيع طبية MeSH: Lactation*/physiology , Osteoporosis*/etiology , Osteoporosis*/metabolism , Bone Density*/physiology , Bone and Bones*/metabolism , Bone and Bones*/physiopathology , Pregnancy Complications*/physiopathology, Humans ; Female ; Pregnancy

المؤلفون: Chandran M; Osteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital, DUKE NUS Medical School, Singapore, Singapore. mchandran7@gmail.com., Akesson KE; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Department of Orthopedics, Skåne University Hospital, Malmö, Sweden., Javaid MK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK., Harvey N; MRC Lifecourse Epidemiology Centre, University of Southampton, NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Blank RD; Garvan Institute of Medical Research, Medical College of Wisconsin, Darlinghurst, NSW, Australia.; Medical College of Wisconsin, Milwaukee, WI, USA., Brandi ML; Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Largo Palagi 1, Florence, Italy., Chevalley T; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Cinelli P; Department of Trauma Surgery, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Cooper C; MRC Lifecourse Epidemiology Centre, University of Southampton, NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.; NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK., Lems W; Department of Rheumatology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands., Lyritis GP; Hellenic Osteoporosis Foundation, Athens, Greece., Makras P; Department of Medical Research, 251 Hellenic Air Force & VA General Hospital, Athens, Greece., Paccou J; Department of Rheumatology, MABlab ULR 4490, CHU Lille, Univ. Lille, 59000, Lille, France., Pierroz DD; International Osteoporosis Foundation, Nyon, Switzerland., Sosa M; University of Las Palmas de Gran Canaria, Investigation Group on Osteoporosis and Mineral Metabolism, Canary Islands, Spain., Thomas T; Department of Rheumatology, North Hospital, CHU Saint-Etienne and INSERM U1059, University of Lyon-University Jean Monnet, Saint‑Etienne, France., Silverman S; Cedars-Sinai Medical Center and Geffen School of Medicine UCLA, Los Angeles, CA, USA.

مؤلفون مشاركون: Fracture Working Group of the Committee of Scientific Advisors of the International Osteoporosis Foundation, on behalf of the International Osteoporosis Foundation, Société Internationale de Chirurgie Orthopédique et de Traumatologie

المصدر: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2024 Aug; Vol. 35 (8), pp. 1337-1358. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer International Country of Publication: England NLM ID: 9100105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2965 (Electronic) Linking ISSN: 0937941X NLM ISO Abbreviation: Osteoporos Int Subsets: MEDLINE

مواضيع طبية MeSH: Fracture Healing*/drug effects , Fracture Healing*/physiology , Bone Density Conservation Agents*/therapeutic use , Bone Density Conservation Agents*/pharmacology , Osteoporotic Fractures*/prevention & control , Osteoporotic Fractures*/physiopathology , Osteoporosis*/drug therapy , Osteoporosis*/physiopathology, Humans ; Teriparatide/therapeutic use ; Teriparatide/pharmacology ; Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/pharmacology

المؤلفون: Correa-Gonzalez N; Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia. nfcorrea@husi.org.co.; Reumatology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia. nfcorrea@husi.org.co., Fernández-Ávila DG; Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia.; Reumatology Unit, Hospital Universitario San Ignacio, Bogotá, Colombia., Rosselli D; Clinical Epidemiology and Biostatistics Department, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia.

المصدر: Archives of osteoporosis [Arch Osteoporos] 2024 Sep 27; Vol. 19 (1), pp. 92. Date of Electronic Publication: 2024 Sep 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: England NLM ID: 101318988 Publication Model: Electronic Cited Medium: Internet ISSN: 1862-3514 (Electronic) NLM ISO Abbreviation: Arch Osteoporos Subsets: MEDLINE

مواضيع طبية MeSH: Osteoporosis*/epidemiology , Osteoporosis*/complications , Osteoporotic Fractures*/epidemiology, Humans ; Colombia/epidemiology ; Male ; Female ; Middle Aged ; Prevalence ; Aged ; Aged, 80 and over ; Sex Distribution

المؤلفون: Vilaca T; Division of Clinical Medicine, University of Sheffield, Sheffield S5 7AU, United Kingdom., Schini M; Division of Clinical Medicine, University of Sheffield, Sheffield S5 7AU, United Kingdom., Lui LY; Research Institute, California Pacific Medical Center, San Francisco, CA 94158, United States., Ewing SK; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94158, United States., Thompson AR; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94158, United States., Vittinghoff E; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94158, United States., Bauer DC; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94158, United States.; Department of Medicine, University of California at San Francisco, San Francisco, CA 94158, United States., Eastell R; Division of Clinical Medicine, University of Sheffield, Sheffield S5 7AU, United Kingdom., Black DM; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94158, United States., Bouxsein ML; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA 02215, United States.

المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2024 Sep 26; Vol. 39 (10), pp. 1434-1442.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Bone and Mineral Research Country of Publication: England NLM ID: 8610640 Publication Model: Print Cited Medium: Internet ISSN: 1523-4681 (Electronic) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE

مواضيع طبية MeSH: Bone Density*/drug effects , Osteoporosis*/drug therapy , Osteoporosis*/diagnostic imaging, Humans ; Female ; Male ; Middle Aged ; Aged ; Randomized Controlled Trials as Topic ; Spinal Fractures/prevention & control ; Spinal Fractures/diagnostic imaging ; Hip/diagnostic imaging ; Time Factors ; Hip Fractures/prevention & control ; Risk Factors