المؤلفون: Catherine Van Renterghem, Ákos Nemecz, Karima Medjebeur, Pierre‐Jean Corringer

المصدر: Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)

مصطلحات موضوعية: GLIC, Loop Ω, orthotopic site, pLGIC, pre‐β5 strand, vestibular site, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-817X

URL الوصول: https://doaj.org/article/f797f6b13a9d453e9028762a82198a87

المؤلفون: Anders A. Jensen

المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)

مصطلحات موضوعية: pentameric ligand-gated ion channel (pLGIC), Zinc-Activated Channel (ZAC), two-electrode voltage-clamp electrophysiology (TEVC), mammalian, evolutionary conservation, zinc, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1265429/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/d9e4a751df1d469699c18d4f5edec2b2

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المؤلفون: Catherine Van Renterghem, Ákos Nemecz, Sandrine Delarue‐Cochin, Delphine Joseph, Pierre‐Jean Corringer

المساهمون: Récepteurs Canaux - Channel Receptors, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), CNRS, MESRI, Université Paris-Saclay and ANR (ANR-13-BSV8-0020) are gratefully acknowledged for financial support., The authors wish to thank Nicolas Bocquet, Virginie Dufresne, Zaineb Fourati, Christèle Huon and Karima Medjebeur for some molecular biology constructs and DNA production, as well as Chantal Jan, Colette Jean and Corinne Balayira for technical assistance with labware. They thank Karine Leblanc for HPLC and HRMS analyses, Laurie Peverini for two 1H NMR spectra at the end of patch-clamp experiments, Nicolas Lenovère for formerly providing a multi-alignment of pLGICs amino acid sequences, and Jean-Marie Biansan for the free software Dozzzaqueux. CVR thanks Frédéric Poitevin, Ludovic Sauguet, Hugues Nury and Marc Delarue for useful discussions at the beginning of this work (starting from 2010)., ANR-13-BSV8-0020,Pentagate,Mécanismes d'activation et de désensibilisation d'un récepteur-canal pentamérique(2013)

المصدر: The Journal of Physiology
The Journal of Physiology, In press, ⟨10.1113/JP283765⟩

مصطلحات موضوعية: pLGIC, vestibular site, fumarate, ligand-gated ion channel, Physiology, allotopic site, positive allosteric modulator, intracellular pH, [CHIM]Chemical Sciences, GLIC, orthosteric site, succinate, orthotopic site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516ad60c6a99572869deff9a768838b1
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093140

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المؤلفون: Pavan V. Payghan, Indrani Bera, Dhananjay Bhattacharyya, Nanda Ghoshal

المصدر: Frontiers in Physics, Vol 6 (2018)

مصطلحات موضوعية: pLGIC, GPCRs, GABA A receptor, structure based drug design, MD simulations, CNS drug discovery, Physics, QC1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphy.2018.00052/full; https://doaj.org/toc/2296-424X

URL الوصول: https://doaj.org/article/76f121833279465ead131a54dc978d5e

المؤلفون: Sandip Basak, author¹, Soumili Chatterjee, author¹, Sudha Chakrapani, author^{1, 2}

المصدر: Journal of Visualized Experiments. (113)

الإتاحة: http://www.jove.com/video/54127

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المؤلفون: Mesoy, Susanne

مصطلحات موضوعية: pLGIC, Cys-loop receptor, 5-HT3, nicotinic acetylcholine receptor, Serotonin receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e25ff28a474e26864e03f774abe2c074

المؤلفون: Marijke Brams, Diletta Pasini, Akshay Sridhar, Chris Ulens, Sarah C. R. Lummis, Kumiko Kambara, Rebecca J. Howard, Aujan Mehregan, Erik Lindahl, Daniel Bertrand

المساهمون: Lummis, Sarah [0000-0001-9410-9805], Apollo - University of Cambridge Repository

المصدر: The Journal of Biological Chemistry
Journal of Biological Chemistry

مصطلحات موضوعية: DYNAMICS, MECHANISM, 0301 basic medicine, Models, Molecular, POPG, palmitoyloleoylphosphatidylglycerol, TMD, transmembrane domain, DOTAP, dipalmitoyl-3-trimethylammonium-propane, PG, phosphatidylglycerol, Crystallography, X-Ray, Biochemistry, ACTIVATION, chemistry.chemical_compound, PC, phosphatidylcholine, Xenopus laevis, Chemistry, GABAA receptor, Editors' Pick, Lipids, Transmembrane domain, VSD, voltage-sensor domain, K+ CHANNEL, Ligand-gated ion channel, Protein Structural Elements, Signal transduction, site-directed mutagenesis, Life Sciences & Biomedicine, Research Article, Protein Binding, STRUCTURAL BASIS, Biochemistry & Molecular Biology, SOFTWARE NEWS, Protein subunit, ICD, intracellular domain, Cys-loop receptor, POPC, palmitoyloleoylphosphatidylcholine, PE, phosphatidylethanolamine, Cell Line, 03 medical and health sciences, pLGIC, pentameric ligand-gated ion channel, Cations, Animals, Humans, Molecular Biology, POPC, Ion channel, G protein-coupled receptor, GPCR, G-protein-coupled receptor, Science & Technology, RECEPTOR, 030102 biochemistry & molecular biology, RMSD, root-mean-squared deviation, Cell Biology, Ligand-Gated Ion Channels, electrophysiology, nAChR, nicotinic acetylcholine receptor, ECD, extracellular domain, WT, wild-type, molecular dynamics, PROTEIN INTERACTIONS, 030104 developmental biology, GENERAL-ANESTHETICS, Biophysics, Oocytes, ELIC, pentameric ligand-gated ion channel, X-RAY-STRUCTURE

وصف الملف: application/pdf; Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b160ea3186d551ffde4ccf17635eb8
http://europepmc.org/articles/PMC8327344