المؤلفون: Kartik S; Department of Pharmacology & Therapeutics, King George's Medical University, 226003, Lucknow, India., Pal R; Department of Pharmacology & Therapeutics, King George's Medical University, 226003, Lucknow, India., Chaudhary MJ; Department of Physiology, Government Medical College, Tirwa Road, Kannauj, India., Tiwari PC; Department of Pharmacology & Therapeutics, King George's Medical University, 226003, Lucknow, India., Nath R; Department of Pharmacology & Therapeutics, King George's Medical University, 226003, Lucknow, India., Kumar M; Department of Pathology, King George's Medical University, Lucknow, 226003, India.

المصدر: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Aug; Vol. 37 (4), pp. 794-806. Date of Electronic Publication: 2023 Feb 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-8206 (Electronic) Linking ISSN: 07673981 NLM ISO Abbreviation: Fundam Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Docosahexaenoic Acids*/pharmacology , Neuroprotective Agents*/pharmacology , Parkinson Disease*/drug therapy , Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism, Animals ; Humans ; Mice ; Antioxidants/pharmacology ; Disease Models, Animal ; Dopaminergic Neurons ; Mice, Inbred C57BL ; Neuroinflammatory Diseases ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Parkinson Disease, Secondary

المؤلفون: Tegtmeyer J; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.; Clinic and Polyclinic for Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Romagnuolo M; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Hammers CM; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.; Department of Dermatology, Allergology and Venerology, University of Lübeck, Lübeck, Germany., Opelka B; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany., Probst C; Institute of Experimental Immunology, EUROIMMUN AG, Lübeck, Germany., Komorowski L; Institute of Experimental Immunology, EUROIMMUN AG, Lübeck, Germany., Marzano AV; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Dermatology Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy., Schmidt E; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.; Department of Dermatology, Allergology and Venerology, University of Lübeck, Lübeck, Germany., Goletz S; Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.

المصدر: Experimental dermatology [Exp Dermatol] 2024 Jul; Vol. 33 (7), pp. e15125.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/immunology , Parkinson Disease*/blood , Collagen Type XVII* , Non-Fibrillar Collagens*/immunology , Pemphigoid, Bullous*/immunology , Pemphigoid, Bullous*/blood , Autoantigens*/immunology , Multiple Sclerosis*/immunology , Multiple Sclerosis*/blood , Autoantibodies*/blood , Autoantibodies*/immunology , Pemphigoid, Benign Mucous Membrane*/immunology , Pemphigoid, Benign Mucous Membrane*/blood, Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Epitopes/immunology ; Protein Domains ; Female ; Male ; Aged

المؤلفون: Cash TV; Department of Neurology, Washington University School of Medicine, USA., Lessov-Schlaggar CN; Department of Psychiatry, Washington University School of Medicine, USA., Foster ER; Department of Neurology, Washington University School of Medicine, USA; Department of Psychiatry, Washington University School of Medicine, USA; Program in Occupational Therapy, Washington University School of Medicine, USA., Myers PS; Department of Neurology, Washington University School of Medicine, USA., Jackson JJ; Department of Psychological and Brain Sciences, Washington University in St. Louis, USA., Maiti B; Department of Neurology, Washington University School of Medicine, USA; Department of Radiology, Washington University School of Medicine, USA., Kotzbauer PT; Department of Neurology, Washington University School of Medicine, USA., Perlmutter JS; Department of Neurology, Washington University School of Medicine, USA; Department of Radiology, Washington University School of Medicine, USA; Department of Neuroscience, Washington University School of Medicine, USA; Program in Occupational Therapy, Washington University School of Medicine, USA; Program in Physical Therapy, Washington University School of Medicine, USA., Campbell MC; Department of Neurology, Washington University School of Medicine, USA; Department of Radiology, Washington University School of Medicine, USA. Electronic address: meghanc@wustl.edu.

المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Jul; Vol. 124, pp. 107016. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/classification , Parkinson Disease*/physiopathology , Parkinson Disease*/diagnosis, Humans ; Female ; Male ; Reproducibility of Results ; Aged ; Middle Aged ; Cohort Studies ; Mental Disorders/classification ; Mental Disorders/diagnosis ; Mental Disorders/etiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/classification ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/diagnosis

المؤلفون: Safarpour D; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: safarpou@ohsu.edu., Stover N; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Shprecher DR; Banner Sun Health Research Institute, Sun City, AZ, USA., Hamedani AG; Departments of Neurology, Ophthalmology, and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pfeiffer RF; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA., Parkman HP; Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA., Quigley EM; Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA., Cloud LJ; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA.

مؤلفون مشاركون: Other Non-motor Features Working Group of the Parkinson Study Group

المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Jul; Vol. 124, pp. 106982. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article; Consensus Development Conference; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/complications , Parkinson Disease*/therapy , Parkinson Disease*/diagnosis , Gastrointestinal Diseases*/etiology , Gastrointestinal Diseases*/therapy , Gastrointestinal Diseases*/diagnosis , Consensus* , Delphi Technique*, Humans

المؤلفون: Zhao Y; Department of Nursing, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China., Wu W; Department of Nursing, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China., Wu J; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China., Shen B; Department of Nursing, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China., Cao Y; Department of Nursing, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China. caoyanpeihs@yeah.net., Xu Y; Department of Nursing, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, China. yafang_xu@fudan.edu.cn.; National Center for Neurological Disorders, Shanghai, China. yafang_xu@fudan.edu.cn.; Huashan Rare Disease Center, Huashan Hospital, Fudan University, Shanghai, China. yafang_xu@fudan.edu.cn.

المصدر: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2024 Jul; Vol. 33 (7), pp. 1753-1766. Date of Electronic Publication: 2024 Apr 04.

نوع المنشور: Journal Article; Systematic Review; Meta-Analysis

بيانات الدورية: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 9210257 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2649 (Electronic) Linking ISSN: 09629343 NLM ISO Abbreviation: Qual Life Res Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/psychology , Parkinson Disease*/therapy , Caregiver Burden*/psychology , Caregivers*/psychology, Humans ; Risk Factors ; Cost of Illness ; Quality of Life ; Adaptation, Psychological

المؤلفون: Proud EL; Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Australia. Electronic address: lproud@unimelb.edu.au., Miller KJ; Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Australia; BC Children's Hospital Research Institute, Vancouver, Canada., Morris ME; Academic and Research Collaborative in Health, La Trobe University, Bundoora, Australia; Victorian Rehabilitation Centre, Healthscope, Glen Waverley, Australia., McGinley JL; Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Australia., Blennerhassett JM; Department of Physiotherapy, and Health Independence Program, Austin Health, Heidelberg, Australia.

المصدر: Archives of physical medicine and rehabilitation [Arch Phys Med Rehabil] 2024 Jul; Vol. 105 (7), pp. 1375-1387. Date of Electronic Publication: 2023 Nov 30.

نوع المنشور: Journal Article; Meta-Analysis; Systematic Review

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 2985158R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-821X (Electronic) Linking ISSN: 00039993 NLM ISO Abbreviation: Arch Phys Med Rehabil Subsets: MEDLINE

مواضيع طبية MeSH: Exercise Therapy*/methods , Hand*/physiopathology , Parkinson Disease*/rehabilitation , Parkinson Disease*/physiopathology , Upper Extremity*/physiopathology, Humans ; Handwriting ; Motor Skills/physiology ; Randomized Controlled Trials as Topic

المؤلفون: Grimaldi S; APHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, 264 rue Saint-Pierre, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France. Electronic address: stephan.grimaldi@ap-hm.fr., Le Troter A; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., El Mendili MM; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., Dary H; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., Azulay JP; APHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, 264 rue Saint-Pierre, Marseille, France., Zaaraoui W; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., Ranjeva JP; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., Eusebio A; APHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CNRS, Institut de Neurosciences de la Timone, 27 Bd Jean-Moulin Marseille, France., de Rochefort L; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France., Guye M; APHM, Hôpital Universitaire Timone, CEMEREM, 264 rue Saint-Pierre, Marseille, France; Aix Marseille Univ, CRMBM, CNRS, 27 Bd Jean-Moulin, Marseille, France.

المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Jul; Vol. 124, pp. 106996. Date of Electronic Publication: 2024 May 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/metabolism , Parkinson Disease*/diagnostic imaging , Parkinson Disease*/physiopathology , Iron Overload*/metabolism , Magnetic Resonance Imaging*, Humans ; Male ; Female ; Middle Aged ; Aged ; Sodium/metabolism ; Substantia Nigra/diagnostic imaging ; Substantia Nigra/metabolism ; Energy Metabolism/physiology ; Prospective Studies

المؤلفون: Fabbri M; Department of Neurosciences, Toulouse Parkinson Expert Center, Centre d'Investigation Clinique de Toulouse CIC1436, NS-Park/FCRIN Network, University Hospital of Toulouse, INSERM, University of Toulouse 3, Toulouse, France., Campisi C; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy., Ledda C; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Rinaldi D; Dipartimento Di Neuroscienze, Salute Mentale E Organi Di Senso, Sapienza Università Di Roma, Via Di Grottarossa, 1035-00189, Rome, Italy., Tsukita K; Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo-Ku, Kyoto, 606-8507, Japan., Romagnolo A; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Imbalzano G; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Zibetti M; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Rizzone MG; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Pontieri FE; Dipartimento Di Neuroscienze, Salute Mentale E Organi Di Senso, Sapienza Università Di Roma, Via Di Grottarossa, 1035-00189, Rome, Italy., Lopiano L; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy., Artusi CA; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy. caartusi@gmail.com.; SC Neurologia 2U, AOU Città Della Salute E Della Scienza, Corso Bramante 88, 10126, Turin, Italy. caartusi@gmail.com.

المصدر: Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4628-4634. Date of Electronic Publication: 2024 May 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/epidemiology , Parkinson Disease*/physiopathology , Parkinson Disease*/complications , Parkinson Disease*/diagnosis, Humans ; Male ; Female ; Aged ; Middle Aged ; Incidence ; Cohort Studies ; Postural Balance/physiology ; Risk Factors ; Follow-Up Studies ; Disease Progression ; Sensation Disorders/etiology ; Sensation Disorders/epidemiology ; Severity of Illness Index

المؤلفون: Skrahin A; Rare Disease Consulting RCV GmbH, Leibnizstrasse 58, 10629 Berlin, Germany., Horowitz M; Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, 6997801 Ramat Aviv, Israel., Istaiti M; Gaucher Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; Agyany Pharma Ltd., 9695614 Jerusalem, Israel., Skrahina V; Agyany Pharma Ltd., 9695614 Jerusalem, Israel., Lukas J; Translational Neurodegeneration Section Albrecht Kossel, Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany., Yahalom G; Department of Neurology and Movement Disorders Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, 9112102 Jerusalem, Israel., Cohen ME; Department of Neurology and Movement Disorders Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, 9112102 Jerusalem, Israel., Revel-Vilk S; Gaucher Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, 9112102 Jerusalem, Israel., Goker-Alpan O; Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA., Becker-Cohen M; Gaucher Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel., Hassin-Baer S; Movement Disorders Institute, Department of Neurology, Chaim Sheba Medical Center, 5262101 Tel-Hashomer, Israel.; Department of Neurology and Neurosurgery, Faculty of Medical and Health Sciences, Tel Aviv University, 6997801 Tel-Aviv, Israel., Svenningsson P; Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden.; Department of Basal and Clinical Neuroscience, King's College London, London SE5 9RT, UK., Rolfs A; Rare Disease Consulting RCV GmbH, Leibnizstrasse 58, 10629 Berlin, Germany.; Agyany Pharma Ltd., 9695614 Jerusalem, Israel.; Medical Faculty, University of Rostock, 18055 Rostock, Germany., Zimran A; Gaucher Unit, Shaare Zedek Medical Center, 9103102 Jerusalem, Israel.; Agyany Pharma Ltd., 9695614 Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, 9112102 Jerusalem, Israel.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 28; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Glucosylceramidase*/genetics , Glucosylceramidase*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Mutation*, Humans ; alpha-Synuclein/metabolism ; alpha-Synuclein/genetics

المؤلفون: Wodarski P; Faculty of Biomedical Engineering, Department of Biomechatronics, Silesian University of Technology, Gliwice, Poland., Jurkojć J; Faculty of Biomedical Engineering, Department of Biomechatronics, Silesian University of Technology, Gliwice, Poland., Chmura M; Faculty of Biomedical Engineering, Department of Biomechatronics, Silesian University of Technology, Gliwice, Poland., Warmerdam E; Division of Surgery, Saarland University, 66421, Homburg, Germany., Romijnders R; Department of Neurology, Kiel University, 24105, Kiel, Germany., Hobert MA; Department of Neurology, Kiel University, 24105, Kiel, Germany., Maetzler W; Department of Neurology, Kiel University, 24105, Kiel, Germany., Cygoń K; Skyfi Sp. z o.o, Gliwice, Poland., Hansen C; Department of Neurology, Kiel University, 24105, Kiel, Germany. C.Hansen@neurologie.uni-kiel.de.

المصدر: Journal of neuroengineering and rehabilitation [J Neuroeng Rehabil] 2024 Jun 28; Vol. 21 (1), pp. 112. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101232233 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-0003 (Electronic) Linking ISSN: 17430003 NLM ISO Abbreviation: J Neuroeng Rehabil Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/physiopathology , Parkinson Disease*/diagnosis , Parkinson Disease*/drug therapy , Postural Balance*/physiology, Humans ; Male ; Female ; Aged ; Middle Aged ; Adult ; Antiparkinson Agents/therapeutic use ; Young Adult