نتائج البحث - "pathology [Neurodegenerative Diseases]"

1

Microglia regulate central nervous system myelin growth and integrity

المساهمون: Molina-Gonzalez, Irene/0000-0001-5966-0351, Miron, Veronique/0000-0003-1738-0647, McNamara, Niamh/0000-0002-9769-367X, Munro, David/0000-0002-3521-2121, McNamara, Niamh B. B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, BOGIE, Jeroen, Hoffmann, Alana, Holloway, Rebecca K. K., Molina-Gonzalez, Irene, Askew, Katharine E. E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W. W., Prinz, Marco, Spires-Jones, Tara L. L., Stenzel, Werner, Horsburgh, Karen, HENDRIKS, Jerome, Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, Miron, Veronique E. E.

المصدر: Nature 613(7942), 120-129 (2023). doi:10.1038/s41586-022-05534-y

مصطلحات موضوعية: Central Nervous System, Adult, metabolism [Myelin Sheath], metabolism [Microglia], metabolism [Neurodegenerative Diseases], metabolism [Axons], cytology [Central Nervous System], metabolism [Oligodendroglia], Mice, Cognition, pathology [Aging], pathology [Myelin Sheath], Humans, Animals, cytology [Microglia], metabolism [Aging], Myelin Sheath, Multidisciplinary, pathology [Neurodegenerative Diseases], pathology [Microglia], Neurodegenerative Diseases, Lipid Metabolism, Axons, metabolism [Receptor, Transforming Growth Factor-beta Type I], Oligodendroglia, metabolism [Transforming Growth Factor beta1], pathology [Oligodendroglia], metabolism [Central Nervous System], Microglia, ddc:500, pathology [Central Nervous System]

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d404a8611c8450df3d12b1580b5c6

2

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

المؤلفون: Laura Malz, Eva M Szego, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksch

المصدر: eLife 11, e81943 (2022). doi:10.7554/eLife.81943

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebd0eda879f38af5d4f9039f24f7b0
https://pubmed.ncbi.nlm.nih.gov/36314770

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3

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

المصدر: Journal of Neuropathology and Experimental Neurology
Journal of neuropathology and experimental neurology 79(11), 1141-1146 (2020). doi:10.1093/jnen/nlaa109

مصطلحات موضوعية: Scientific practice, AcademicSubjects/MED00994, tau Proteins, Disease, Review Article, Neurodegenerative disease, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Animal model, Animals laboratory, pathology [Proteostasis Deficiencies], Medicine, Neural system, Animals, Humans, ddc:610, metabolism [alpha-Synuclein], Proteostasis Deficiencies, Propagation, 030304 developmental biology, Aβ, α-Synuclein, 0303 health sciences, Amyloid beta-Peptides, business.industry, Transmissibility, pathology [Neurodegenerative Diseases], Neurodegenerative Diseases, General Medicine, metabolism [tau Proteins], Neurology, alpha-Synuclein, Infectious etiology, α synuclein, Neurology (clinical), Tau, business, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b04ff8d370b02ea54af1da56b42d2b7
http://europepmc.org/articles/PMC7577514

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4

Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid‐binding protein 3 and ferritin to neurodegeneration and neuroinflammation

المؤلفون: Frank Jessen, Carl-Christian Kolbe, Sergio Castro-Gomez, Pawel Tacik, Kilian Kleemann, Eicke Latz, Francesco Santarelli, Frederic Brosseron, Michael T. Heneka

المصدر: Journal of neurochemistry 157(6), 2210-2224 (2021). doi:10.1111/jnc.15175

مصطلحات موضوعية: Male, 0301 basic medicine, Apolipoprotein E, Alzheimer´s disease, Biochemistry, neuroinflammation, Cohort Studies, pathology [Alzheimer Disease], 0302 clinical medicine, cerebrospinal fluid [Ferritins], Neurogranin, biology, Neurodegeneration, pathology [Neurodegenerative Diseases], neurodegeneration, Neurodegenerative Diseases, cerebrospinal fluid [Alzheimer Disease], cerebrospinal fluid [Inflammation], cerebrospinal fluid [Biomarkers], biomarker, Biomarker (medicine), Female, medicine.symptom, Fatty Acid Binding Protein 3, medicine.medical_specialty, Inflammation, 03 medical and health sciences, Cellular and Molecular Neuroscience, Alzheimer Disease, Internal medicine, medicine, Humans, ddc:610, Neuroinflammation, pathology [Inflammation], business.industry, medicine.disease, Ferritin, 030104 developmental biology, Endocrinology, Ferritins, biology.protein, cerebrospinal fluid [Neurodegenerative Diseases], Macrophage migration inhibitory factor, cerebrospinal fluid [Neurogranin], business, Biomarkers, 030217 neurology & neurosurgery, cerebrospinal fluid [Fatty Acid Binding Protein 3]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669f6412a8a900d4d3fcf5b53bb82dc
https://doi.org/10.1111/jnc.15175

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5

Lifetime risk of autosomal recessive neurodegeneration with brain iron accumulation (NBIA) disorders calculated from genetic databases

المؤلفون: Hana Kolarova, Jing Tan, Tim M. Strom, Thomas Meitinger, Matias Wagner, Thomas Klopstock

المصدر: EBioMedicine 77, 103869 (2022). doi:10.1016/j.ebiom.2022.103869
EBioMedicine 77:103869 (2022)
EBioMedicine, Vol 77, Iss, Pp 103869-(2022)

مصطلحات موضوعية: DCAF17 protein, human, Medicine (General), genetics [Iron Metabolism Disorders], PLAN, PKAN, Neuroaxonal Dystrophies, epidemiology [Neuroaxonal Dystrophies], General Biochemistry, Genetics and Molecular Biology, genetics [Neuroaxonal Dystrophies], Mitochondrial Proteins, R5-920, pathology [Neuroaxonal Dystrophies], pathology [Brain], Databases, Genetic, Humans, Autosomal recessive NBIA disorders, CoPAN, ddc:610, Neurodegeneration, Child, C19orf12 protein, human, Autosomal Recessive Nbia Disorders, Copan, Lifetime Risk, Pkan, Plan, Calcium-Binding Proteins, pathology [Neurodegenerative Diseases], Brain, Nuclear Proteins, Ubiquitin-Protein Ligase Complexes, Neurodegenerative Diseases, General Medicine, Iron Metabolism Disorders, Lifetime risk, REPS1 protein, human, genetics [Neurodegenerative Diseases], pathology [Iron Metabolism Disorders], Medicine, genetics [Mitochondrial Proteins], epidemiology [Neurodegenerative Diseases]

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c582c79e062a09eafa866e0479ccdb
https://pub.dzne.de/record/163460

6

Biomolecular condensation of the microtubule-associated protein tau

المؤلفون: Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter

المصدر: Seminars in cell & developmental biology 99, 202-214 (2020). doi:10.1016/j.semcdb.2019.06.007
Seminars in Cell & Developmental Biology
Seminars in Cell and Developmental Biology

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https://doi.org/10.1016/j.semcdb.2019.06.007

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7

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

المؤلفون: Muhammet M Öztürk, Bryce L Mashimo, Maria Medalla, Lulu Jiang, Samantha Boudeau, Peter E.A. Ash, Guillermo Socorro, Jenifer Shattuck, Susanne Wegmann, Pavel Ivanov, Yari Carlomagno, Nicholas M. Kanaan, Benjamin Wolozin, Mark Knobel, Leonard Petrucelli, Shuwen Lei, Louloua F A Al-Mohanna

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(9), e2014188118-(2021). doi:10.1073/pnas.2014188118

مصطلحات موضوعية: metabolism [T-Cell Intracellular Antigen-1], Amyloid, TIA1, Tau protein, metabolism [RNA Recognition Motif Proteins], RNA-binding protein, tau Proteins, metabolism [Neurodegenerative Diseases], Fibril, Protein Aggregation, Pathological, etiology [Neurodegenerative Diseases], Protein Aggregates, Stress granule, chemistry [RNA Recognition Motif Proteins], mental disorders, Organelle, chemistry [Amyloid], Humans, fibrillar tau, Protein Interaction Domains and Motifs, oligomeric tau, metabolism [Amyloid], Neurons, Multidisciplinary, biology, Chemistry, chemistry [tau Proteins], pathology [Neurodegenerative Diseases], RNA, Neurodegenerative Diseases, Biological Sciences, Alzheimer's disease, In vitro, metabolism [tau Proteins], Recombinant Proteins, T-Cell Intracellular Antigen-1, RNA Recognition Motif Proteins, metabolism [Neurons], biology.protein, Biophysics, liquid–liquid phase separation (LLPS), ddc:500, RNA binding proteins, Protein Multimerization, Neuroscience, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d0a132fc70ab180f1313204a691274
http://europepmc.org/articles/PMC7936275

8

In vivoimaging reveals reduced activity of neuronal circuits in a mouse tauopathy model

المؤلفون: Petar Marinković, Jochen Herms, Pieter M. Goltstein, Finn Peters, Sonja Blumenstock, Andreas Knebl, Viktoria Korzhova

المصدر: Brain 142(4), 1051-1062 (2019). doi:10.1093/brain/awz035
Brain

مصطلحات موضوعية: Male, 0301 basic medicine, Tau protein, Hyperphosphorylation, Mice, Transgenic, tau Proteins, Mice, 03 medical and health sciences, 0302 clinical medicine, Calcium imaging, diagnostic imaging [Tauopathies], medicine, Animals, Humans, ddc:610, Phosphorylation, Neurons, biology, Chemistry, pathology [Neurodegenerative Diseases], Neurodegenerative Diseases, Neurofibrillary Tangles, Neurofibrillary tangle, medicine.disease, Spinal cord, metabolism [tau Proteins], Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Tauopathies, metabolism [Neurons], Frontotemporal Dementia, pathology [Frontotemporal Dementia], biology.protein, Female, pathology [Neurofibrillary Tangles], Neurology (clinical), Tauopathy, Brainstem, metabolism [Tauopathies], 030217 neurology & neurosurgery, Frontotemporal dementia

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https://doi.org/10.1093/brain/awz035

9

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

المؤلفون: Peter C. Reinacher, Josef Priller, Ralf Gold, Anna Michel, Geert van Loo, Ulrich Sure, Marco Prinz, Roman Sankowski, Christine Stadelmann, Sagar, Dominic Grün, Takahiro Masuda, Stefan Nessler, Ori Staszewski, Volker A. Coenen, Christian Scheiwe, Patrik Kunz, Lukas Amann, Chotima Böttcher

المصدر: Masuda, T, Sankowski, R, Staszewski, O, Böttcher, C, Amann, L, Scheiwe, C, Nessler, S, Kunz, P, van Loo, G, Arnd Coenen, V, Reinacher, P C, Michel, A, Sure, U, Gold, R, Grün, D, Priller, J, Stadelmann, C & Prinz, M 2019, ' Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution ', Nature, vol. 566, no. 7744, pp. 388-392 . https://doi.org/10.1038/s41586-019-0924-x
Nature 566(7744), 388-392 (2019). doi:10.1038/s41586-019-0924-x
Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Multiple Sclerosis, Central nervous system, Medizin, Cell Separation, Disease, Biology, Mice, 03 medical and health sciences, Spatio-Temporal Analysis, 0302 clinical medicine, Immune system, Single-cell analysis, pathology [Brain], medicine, cytology [Microglia], Animals, Humans, classification [Microglia], Multidisciplinary, Microglia, cytology [Brain], Multiple sclerosis, pathology [Neurodegenerative Diseases], Brain, Neurodegenerative Diseases, pathology [Multiple Sclerosis], medicine.disease, Kinetics, 030104 developmental biology, medicine.anatomical_structure, Case-Control Studies, Female, ddc:500, Single-Cell Analysis, pathology [Demyelinating Diseases], Neuroscience, Neural development, 030217 neurology & neurosurgery, Homeostasis, Demyelinating Diseases

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368ad77538dcab2f43f3ea8b59015268
https://doi.org/10.1038/s41586-019-0924-x

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10

Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin

المؤلفون: Nefeli Zacharopoulou, Christos Stournaras, Bhuyan Aam, Itishri Sahu, Zohreh Hosseinzadeh, Ludger Schöls, Basma Sukkar, Florian Lang, Tamer Al-Maghout, Lisann Pelzl, Stefan Hauser

المصدر: Cellular Physiology and Biochemistry, Vol 51, Iss 1, Pp 278-289 (2018)
Cellular physiology and biochemistry 51(1), 278-289 (2018). doi:10.1159/000495229

مصطلحات موضوعية: 0301 basic medicine, Orai1, Patch-Clamp Techniques, ORAI1 Protein, Physiology, Cellular differentiation, Gene Expression, STIM1 protein, human, metabolism [Neurodegenerative Diseases], wogonin, lcsh:Physiology, Membrane Potentials, chemistry.chemical_compound, metabolism [Calcium], lcsh:QD415-436, genetics [ORAI1 Protein], Cells, Cultured, Neurons, lcsh:QP1-981, Kinase, ORAI1, pathology [Neurodegenerative Diseases], NF-kappa B, Neurodegenerative Diseases, Cell Differentiation, drug effects [Gene Expression], metabolism [Stromal Interaction Molecule 1], cytology [Induced Pluripotent Stem Cells], Neoplasm Proteins, Cell biology, metabolism [Neurons], metabolism [ORAI1 Protein], metabolism [Neoplasm Proteins], Flavanones, metabolism [NF-kappa B], Thapsigargin, pharmacology [Flavanones], SOCE, Induced Pluripotent Stem Cells, Calcium-Transporting ATPases, Lithium, lcsh:Biochemistry, 03 medical and health sciences, Wogonin, Downregulation and upregulation, genetics [Stromal Interaction Molecule 1], ddc:570, pharmacology [Thapsigargin], antagonists & inhibitors [Calcium-Transporting ATPases], Humans, antagonists & inhibitors [NF-kappa B], drug effects [Neurons], Stromal Interaction Molecule 1, Patch clamp, metabolism [Calcium-Transporting ATPases], genetics [Neoplasm Proteins], pharmacology [Lithium], Chorein, drug effects [Membrane Potentials], 030104 developmental biology, chemistry, cytology [Neurons], SGK1, Calcium, NFκB

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065a98c934df070a5ce682a783fb6020
https://www.karger.com/Article/FullText/495229

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