المؤلفون: Xie X; Department of Nephrology, 184 Hospital, Yingtan, Jiangxi Province, China., Huang F; Department of Nephrology, 184 Hospital, Yingtan, Jiangxi Province, China., Tong X; Department of Nephrology, 184 Hospital, Yingtan, Jiangxi Province, China., Wang M; Department of Nephrology, 184 Hospital, Yingtan, Jiangxi Province, China., Wu R; Department of Nephrology, 184 Hospital, Yingtan, Jiangxi Province, China.

المصدر: The Journal of international medical research [J Int Med Res] 2024 Sep; Vol. 52 (9), pp. 3000605241260556.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE

مواضيع طبية MeSH: Peritoneal Dialysis, Continuous Ambulatory*/adverse effects , Peritoneal Dialysis, Continuous Ambulatory*/instrumentation, Humans ; Middle Aged ; Male ; Female ; Aged ; Retrospective Studies ; Catheters, Indwelling/adverse effects ; Colonoscopy/methods ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Peritonitis/etiology ; Peritonitis/diagnosis ; Peritoneal Dialysis/instrumentation ; Peritoneal Dialysis/adverse effects ; Adult

المؤلفون: Shi SS; Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, Shanxi, China.; Department of Nephrology, Heji Hospital of Changzhi Medical College, Changzhi, 046011, Shanxi, China., Zhang YQ; Department of Biochemistry, Changzhi Medical College, Changzhi, 046000, Shanxi, China., Zhang LQ; First Clinical Department of Changzhi Medical College, Changzhi, 046000, Shanxi, China., Li YF; First Clinical Department of Changzhi Medical College, Changzhi, 046000, Shanxi, China., Zhou XS; Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, Shanxi, China., Li RS; Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, Shanxi, China. rongshanli@126.com.

المصدر: International urology and nephrology [Int Urol Nephrol] 2024 Aug; Vol. 56 (8), pp. 2659-2670. Date of Electronic Publication: 2024 Mar 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE

مواضيع طبية MeSH: Sirtuins*/metabolism , Sirtuins*/genetics , Peritoneal Dialysis* , Peritoneum*/metabolism , Peritoneum*/cytology , Epithelial Cells*/metabolism, Humans ; Male ; Middle Aged ; Female ; Cells, Cultured ; Transforming Growth Factor beta1/metabolism ; Vimentin/metabolism ; Aged ; Peritoneal Fibrosis/metabolism ; Peritoneal Fibrosis/etiology ; Cadherins/metabolism ; Adult ; Epithelial-Mesenchymal Transition

المؤلفون: Yeter HH; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Hacettepe University, TR-06560, Ankara, Turkey. hasanyeter@hotmail.com., Altunok M; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Ataturk University, Erzurum, Turkey., Cankaya E; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Ataturk University, Erzurum, Turkey., Yildirim S; Department of Nephrology, Sincan State Hospital, Ankara, Turkey., Akturk S; Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey., Bakirdogen S; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, 18 Mart University, Canakkale, Turkey., Akoğlu H; Department of Nephrology, Gulhane Education and Research Hospital, Ankara, Turkey., Bulut M; Department of Nephrology, Gulhane Education and Research Hospital, Ankara, Turkey., Sahutoglu T; Department of Nephrology, Mehmet Akif Ersoy Education and Research Hospital, Sanliurfa, Turkey., Erdut A; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Hacettepe University, TR-06560, Ankara, Turkey., Ozkahya M; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Ege University, Izmir, Turkey., Koc Y; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Tunca O; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Afyonkarahisar Health Science University, Afyon, Turkey., Kara E; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey., Erek M; Department of Nephrology, Harakani State Hospital, Kars, Turkey., Polat M; Department of Nephrology, Nevsehir State Hospital, Nevsehir, Turkey., Akagun T; Department of Nephrology, Giresun Education and Research Hospital, Giresun, Turkey., Guz G; Department of Nephrology Dialysis and Transplantation, Faculty of Medicine, Gazi University, Ankara, Turkey.

المصدر: International urology and nephrology [Int Urol Nephrol] 2024 Sep; Vol. 56 (9), pp. 3123-3132. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article; Observational Study; Multicenter Study

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE

مواضيع طبية MeSH: Glucose* , Peritoneal Dialysis* , Dialysis Solutions*/chemistry, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Hydrogen-Ion Concentration ; Aged ; Treatment Outcome ; Peritoneal Dialysis, Continuous Ambulatory ; Kidney Failure, Chronic/therapy ; Retrospective Studies ; Adult

المؤلفون: Lotfollahzadeh S; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.; Department of Surgery, Boston University School of Medicine, Boston, Massachusetts., Vazirani A; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.; Department of Surgery, Boston University School of Medicine, Boston, Massachusetts., Sellinger IE; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Clovie J; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Hoekstra I; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Patel A; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Malloum AB; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Yin W; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Paul H; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Yadati P; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Siracus J; Department of Surgery, Boston University School of Medicine, Boston, Massachusetts., Malikova M; Department of Surgery, Boston University School of Medicine, Boston, Massachusetts., Pernar LI; Department of Surgery, Boston University School of Medicine, Boston, Massachusetts., Francis J; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Stern L; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Chitalia VC; Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.; Veterans Affairs Boston Healthcare System, Boston, Massachusetts.; Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

المصدر: Kidney360 [Kidney360] 2024 Sep 01; Vol. 5 (9), pp. 1238-1250. Date of Electronic Publication: 2024 Sep 05.

نوع المنشور: Letter; Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 101766381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2641-7650 (Electronic) Linking ISSN: 26417650 NLM ISO Abbreviation: Kidney360 Subsets: MEDLINE

مواضيع طبية MeSH: Disease Models, Animal* , Receptors, Aryl Hydrocarbon*/metabolism , Peritoneal Fibrosis*/etiology , Peritoneal Fibrosis*/pathology , Peritoneal Fibrosis*/metabolism , Renal Insufficiency, Chronic*/pathology, Animals ; Mice ; Peritoneal Dialysis/adverse effects ; Dialysis Solutions/chemistry ; Dialysis Solutions/adverse effects ; Signal Transduction/drug effects

المؤلفون: Ehleiter H; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany., Miranda J; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany., Boes D; Kuratorium for Dialysis, KfH Renal Center, Bonn, Germany., Scheidt U; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany., von Vietinghoff S; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany., Schwab S; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany. Sebastian.Schwab@ukbonn.de.

المصدر: BMC nephrology [BMC Nephrol] 2024 Aug 23; Vol. 25 (1), pp. 268. Date of Electronic Publication: 2024 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE

مواضيع طبية MeSH: Peritoneal Dialysis* , Adaptor Proteins, Signal Transducing*/metabolism, Humans ; Male ; Female ; Middle Aged ; Chemokines/blood ; Chemokines/metabolism ; Aged ; Adult ; Intercellular Signaling Peptides and Proteins/metabolism ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/metabolism ; Biomarkers/blood ; Dialysis Solutions/metabolism ; Kidney/metabolism ; Peritoneum/metabolism ; Peritoneal Dialysis, Continuous Ambulatory ; Renin-Angiotensin System/physiology ; Creatinine/urine ; Creatinine/blood ; Creatinine/metabolism

المؤلفون: Zheng L; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China., Chen W; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China., Yao K; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China., Xie Y; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China., Liao C; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China., Zhou T; Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, No. 69 Dongsha Road, Shantou, 515041, China. zhoutb@aliyun.com.

المصدر: Stem cell research & therapy [Stem Cell Res Ther] 2024 Jul 30; Vol. 15 (1), pp. 237. Date of Electronic Publication: 2024 Jul 30.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Peritoneal Fibrosis*/therapy , Peritoneal Fibrosis*/metabolism , Peritoneal Fibrosis*/pathology , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cell Transplantation*/methods, Humans ; Animals ; Peritoneal Dialysis/adverse effects ; Signal Transduction

المؤلفون: Tanemura M; Department of Surgery, Rinku General Medical Center, 2-23 Rinku Orai-kita, Izumisano, Osaka, 598-8577, Japan. mtanemuram64@gmail.com., Furukawa K; Department of Surgery, Osaka Police Hospital, 10-31 Kitayamachyo, Tennouji-ku, Osaka, 543-0035, Japan., Mikamori M; Department of Surgery, Osaka Police Hospital, 10-31 Kitayamachyo, Tennouji-ku, Osaka, 543-0035, Japan., Asaoka T; Department of Surgery, Osaka Police Hospital, 10-31 Kitayamachyo, Tennouji-ku, Osaka, 543-0035, Japan., Yasuoka H; Department of Pathology, Osaka Police Hospital, 10-31 Kitayamachyo, Tennouji-ku, Osaka, 543-0035, Japan., Marukawa D; Department of Surgery, Rinku General Medical Center, 2-23 Rinku Orai-kita, Izumisano, Osaka, 598-8577, Japan., Urata Y; Oncolys BioPharma Inc., Toranomon Towers 10F, 4-1-28 Toranomon, Minato-ku, Tokyo, 105-0001, Japan., Yamada D; Department of Gastroenterological Surgery, Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Kobayashi S; Department of Gastroenterological Surgery, Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan., Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

المصدر: Scientific reports [Sci Rep] 2024 May 03; Vol. 14 (1), pp. 10199. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/diagnosis , Pancreatectomy* , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/diagnosis , Pancreatic Neoplasms*/surgery , Peritoneal Lavage*, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Cytodiagnosis/methods ; Liquid Biopsy/methods ; Neoplasm Recurrence, Local/pathology ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/diagnosis

المؤلفون: Takahashi K; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan., Tsuji K; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan., Nakanoh H; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan., Fukushima K; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.; Division of Nephrology, Department of Medicine, Center for Systems Biology, Program in Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kitamura S; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.; Department of Nursing Science, Faculty of Health and Welfare Science, Okayama Prefectural University Japan., Wada J; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

المصدر: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis [Perit Dial Int] 2024 May; Vol. 44 (3), pp. 211-215. Date of Electronic Publication: 2023 Nov 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8904033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1718-4304 (Electronic) Linking ISSN: 08968608 NLM ISO Abbreviation: Perit Dial Int Subsets: MEDLINE

مواضيع طبية MeSH: Peritoneal Fibrosis*/prevention & control , Peritoneal Fibrosis*/etiology , Peritoneal Fibrosis*/metabolism , Peritoneal Fibrosis*/pathology , Peritoneum*/pathology , Peritoneum*/metabolism , Epithelial Cells*/metabolism, Animals ; Mice ; Humans ; Cells, Cultured ; Mice, Nude ; Disease Models, Animal ; Male ; Peritoneal Dialysis/adverse effects

المؤلفون: Kim JE; Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea., Han D; Proteomics Core Facility, Seoul National University Hospital, Seoul, Korea., Kim KH; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea., Seo A; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea., Moon JJ; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Jeong JS; Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea., Kim JH; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea., Kang E; Transplantation Center, Seoul National University Hospital, Seoul, Korea., Bae E; Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea., Kim YC; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea., Lee JW; Nephrology Clinic, National Cancer Center, Goyang, Korea., Cha RH; Department of Internal Medicine, National Medical Center, Seoul, Korea., Kim DK; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea., Oh KH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Kim YS; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea., Jung HY; R&D Center, NovMetaPharma Co., Ltd, Pohang, Korea.; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea., Yang SH; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jul; Vol. 38 (13), pp. e23819.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Peritoneal Fibrosis*/metabolism , Peritoneal Fibrosis*/prevention & control , Peritoneal Fibrosis*/pathology, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Peritoneal Dialysis/adverse effects ; Peritoneum/pathology ; Peritoneum/metabolism

المؤلفون: Fabbri C; Nephrology, Dialysis, Hypertension Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna., La Malfa E; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Ricco M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Godino L; SIAN, Italian Nephrological Nursing Society, Olbia, Italy., Mancin S; IRCCS Humanitas Research Hospital, Rozzano, Italy., Longo W; Nephrology, Dialysis, Hypertension Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna., Spadafora G; Nephrology, Dialysis, Hypertension Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna., Del Grosso B; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Sguanci M; SIAN, Italian Nephrological Nursing Society, Olbia, Italy., Zito MP; SIAN, Italian Nephrological Nursing Society, Olbia, Italy., Cinocca S; Governo Clinico e Qualità, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Gazineo D; SIAN, Italian Nephrological Nursing Society, Olbia, Italy.

المصدر: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2024 Jun 28; Vol. 41 (3). Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article; Observational Study

بيانات الدورية: Publisher: Società Italiana di Nefrologia Country of Publication: Italy NLM ID: 9426434 Publication Model: Electronic Cited Medium: Internet ISSN: 1724-5990 (Electronic) Linking ISSN: 03935590 NLM ISO Abbreviation: G Ital Nefrol Subsets: MEDLINE

مواضيع طبية MeSH: Peritonitis*/etiology , Peritonitis*/epidemiology , Peritoneal Dialysis*/adverse effects, Humans ; Retrospective Studies ; Prognosis ; Male ; Female ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects ; Aged