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المؤلفون: Elżbieta Lipska, Agnieszka Lecka-Ambroziak, Daniel Witkowski, Katarzyna Szamotulska, Ewa Mierzejewska, Mariusz Ołtarzewski

المصدر: Frontiers in Endocrinology, Vol 13 (2022)

مصطلحات موضوعية: congenital hypothyroidism, permanent CH, transient CH, neurodevelopment, neonatal screening, TSH threshold, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.895507/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/fbc3a2d2b4b14ffc93be55aeeaf96c48

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المؤلفون: Fan Xin, Chuan Li, Jingi Luo, Shaoke Chen, Jiale Qian, Qin Tang, Caijuan Lin, Suren R. Sooranna

المصدر: Global Pediatric Health
Global Pediatric Health, Vol 2 (2015)

مصطلحات موضوعية: iodine deficiency, education.field_of_study, Newborn screening, Pediatrics, medicine.medical_specialty, business.industry, Incidence (epidemiology), Population, lcsh:RJ1-570, congenital hypothyroidism, lcsh:Pediatrics, medicine.disease, Iodine deficiency, Congenital hypothyroidism, transient CH, Thyroid-stimulating hormone, Who guidelines, Pediatrics, Perinatology and Child Health, medicine, In patient, Original Article, permanent CH, education, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7571b2f2c5fa2ddee62514f328a3ee0
http://europepmc.org/articles/PMC4784601

المؤلفون: Chiara Azzari, G. Bindi, Fiorella Galluzzi, Stefano Stagi, Alberto Vierucci, Sergio Nanni, Roberto Salti

المصدر: Clinical Immunology. 116:94-98

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, endocrine system diseases, Immunology, Neonatal Screening, Immune system, Hypothyroidism, Internal medicine, Immunopathology, Congenital Hypothyroidism, Humans, Immunology and Allergy, Medicine, IgM deficiency, biology, business.industry, Some studies suggest thyroid hormones may regulate the human immune system. In order to evaluate the effect of thyroid hormone deficiency on antibody production, we evaluated serum IgA and IgM concentrations in 83 children with congenital hypothyroidism (CH), diagnosed by neonatal screening. Patients were compared to two healthy, age-matched control groups. Patients with permanent CH had a significantly higher frequency of undetectable IgA concentrations (thyroid agenesis, P<10(-5), thyroid ectopy, P=0.013) and lower concentrations of IgA (thyroid agenesis, P<10(-6), thyroid ectopy, P<10(-5), dyshormonogenesis, P=0.0002) and IgM (thyroid agenesis, P=0.0002, thyroid ectopy, P<10(-6), dyshormonogenesis, P=0.0017) compared to control group. No difference was observed between patients with transient hypothyroidism and controls. A significant correlation was observed between serum IgA and IgM concentrations and fT4 levels. IgA and IgM deficiency is correlated with the severity of congenital hypothyroidism and may help to evaluate the duration and severity of thyroid hormone deficiency during prenatal life, Thyroid, Infant, Newborn, Infant, medicine.disease, Thyroid agenesis, Immunoglobulin A, Congenital hypothyroidism, Endocrinology, medicine.anatomical_structure, Immunoglobulin M, biology.protein, Female, Antibody, business, Biomarkers, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d19458aeede3ab09ffb7aeae8a3026f
https://doi.org/10.1016/j.clim.2005.03.003