المؤلفون: Thakur K; Simcyp Division, Certara UK Limited, Sheffield, UK., Telaprolu KC; Simcyp Division, Certara UK Limited, Sheffield, UK., Paterson D; Simcyp Division, Certara UK Limited, Sheffield, UK., Salem F; Simcyp Division, Certara UK Limited, Sheffield, UK.; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Arora S; Simcyp Division, Certara UK Limited, Sheffield, UK.; Janssen Pharmaceutical, Companies of Johnson & Johnson, Beerse, Belgium., Polak S; Simcyp Division, Certara UK Limited, Sheffield, UK.; Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.

المصدر: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Jun; Vol. 90 (6), pp. 1428-1449. Date of Electronic Publication: 2024 Mar 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological* , Vaginal Creams, Foams, and Jellies*/administration & dosage , Vaginal Creams, Foams, and Jellies*/pharmacokinetics , Contraceptive Devices, Female* , Tenofovir*/pharmacokinetics , Tenofovir*/administration & dosage , Vagina*/metabolism , Vagina*/drug effects , Vaginal Absorption* , Computer Simulation*, Female ; Humans ; Administration, Intravaginal ; Ethinyl Estradiol/pharmacokinetics ; Ethinyl Estradiol/administration & dosage ; Desogestrel/administration & dosage ; Desogestrel/pharmacokinetics ; Pyrimidines/pharmacokinetics ; Pyrimidines/administration & dosage ; Adult ; Area Under Curve ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/administration & dosage

المؤلفون: Xu X; Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China.; Institute of Clinical Pharmacology, Sun Yat-sen University, Guangzhou, China., Zhang H; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Liu L; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Fu Q; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Wu C; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Lin X; Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Tang K; Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China., Wang C; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China. wangchx@mail.sysu.edu.cn., Chen P; Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, China. chenp73@mail.sysu.edu.cn.

المصدر: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2024 Aug; Vol. 80 (8), pp. 1219-1227. Date of Electronic Publication: 2024 May 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1041 (Electronic) Linking ISSN: 00316970 NLM ISO Abbreviation: Eur J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Kidney Transplantation* , Ritonavir*/pharmacokinetics , Ritonavir*/pharmacology , Drug Interactions* , Calcineurin Inhibitors*/pharmacokinetics , Calcineurin Inhibitors*/pharmacology , Calcineurin Inhibitors*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Adult ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A/genetics ; Immunosuppressive Agents/pharmacokinetics ; Immunosuppressive Agents/administration & dosage ; Prospective Studies ; Tacrolimus/pharmacokinetics ; Tacrolimus/administration & dosage ; Tacrolimus/pharmacology ; Genotype ; Area Under Curve ; Transplant Recipients

المؤلفون: Wilson LC; Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand., Ward J; Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand., Wright DFB; School of Pharmacy, University of Otago, Dunedin, New Zealand.; Sydney Pharmacy School, University of Sydney, Sydney, New South Wales, Australia., Green SC; Department of Medicine, University of Otago, Christchurch, New Zealand., Stocker SL; Sydney Pharmacy School, University of Sydney, Sydney, New South Wales, Australia.; Department of Clinical Pharmacology & Toxicology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.; Sydney Musculoskeletal Health, Univ. of Sydney, Sydney, New South Wales, Australia., Putt TL; Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand., Schollum JBW; Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand., Walker RJ; Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand.

المصدر: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2024 Aug; Vol. 29 (8), pp. 547-550. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9615568 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1797 (Electronic) Linking ISSN: 13205358 NLM ISO Abbreviation: Nephrology (Carlton) Subsets: MEDLINE

مواضيع طبية MeSH: Uric Acid*/blood , Gout*/drug therapy , Gout*/blood , Peritoneal Dialysis* , Oxypurinol*/pharmacokinetics , Gout Suppressants*/pharmacokinetics , Gout Suppressants*/therapeutic use, Humans ; Male ; Middle Aged ; Female ; Aged ; Allopurinol/therapeutic use ; Allopurinol/pharmacokinetics ; Renal Elimination ; Half-Life ; Dialysis Solutions/pharmacokinetics

المؤلفون: Wang YN; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Jin H; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Fan HR; Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China., Wang BL; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

المصدر: Journal of Asian natural products research [J Asian Nat Prod Res] 2024 Aug; Vol. 26 (8), pp. 930-944. Date of Electronic Publication: 2024 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

مواضيع طبية MeSH: Flavonoids*/pharmacokinetics , Flavonoids*/chemistry , Plant Leaves*/chemistry , Kaempferols*/pharmacokinetics , Kaempferols*/chemistry, Animals ; Rats ; Molecular Structure ; Male ; Rutin/pharmacokinetics ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Rats, Sprague-Dawley ; Calycanthaceae/chemistry ; Chromatography, Liquid/methods ; Biological Availability ; Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Liquid Chromatography-Mass Spectrometry

المؤلفون: Elendran S; School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia., Shiva Kumar V; RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, 641402, India., Sundralingam U; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia. Electronic address: usha.sundralingam@monash.edu., Tow WK; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia., Palanisamy UD; School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia. Electronic address: umadevi.palaniamy@monash.edu.

المصدر: International journal of pharmaceutics [Int J Pharm] 2024 Jul 20; Vol. 660, pp. 124333. Date of Electronic Publication: 2024 Jun 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Biological Availability* , Hydrolyzable Tannins*/pharmacokinetics , Hydrolyzable Tannins*/chemistry , Hydrolyzable Tannins*/administration & dosage , Glucosides*/pharmacokinetics , Glucosides*/chemistry , Glucosides*/administration & dosage , Glucosides*/blood, Animals ; Rabbits ; Administration, Oral ; Male ; Particle Size ; Phosphatidylcholines/chemistry ; Solubility ; Chemistry, Pharmaceutical/methods ; Ellagic Acid/pharmacokinetics ; Ellagic Acid/chemistry ; Ellagic Acid/administration & dosage ; Ellagic Acid/blood ; Tannins/chemistry ; Tannins/pharmacokinetics ; Tannins/administration & dosage

المؤلفون: Panjasawatwong N; Department of Pharmaceutical Care, Faculty of Pharmacy, Payap University, Chiang Mai, Thailand., Avihingsanon A; The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Center, Bangkok, Thailand., Menétrey C; Drugs for Neglected Diseases Initiative, Geneva, Switzerland., Ribeiro I; Drugs for Neglected Diseases Initiative, Geneva, Switzerland., Salvadori N; AMS-PHPT Collaboration, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand., Swanson A; Drugs for Neglected Diseases Initiative, Geneva, Switzerland., Gillon J-Y; Drugs for Neglected Diseases Initiative, Geneva, Switzerland., Tan S-S; Department of Hepatology, Selayang Hospital, Selayang, Malaysia., Thanprasertsuk S; Department of Disease Control, Ministry of Public Health, Bangkok, Thailand., Thongsawat S; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Cressey TR; AMS-PHPT Collaboration, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

مؤلفون مشاركون: STORM-C-1 study team

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0000824. Date of Electronic Publication: 2024 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis C, Chronic*/drug therapy , Antiviral Agents*/pharmacokinetics , Antiviral Agents*/therapeutic use , HIV Infections*/drug therapy , HIV Infections*/virology , Valine*/pharmacokinetics , Valine*/analogs & derivatives, Humans ; Male ; Female ; Middle Aged ; Adult ; Sofosbuvir/pharmacokinetics ; Sofosbuvir/therapeutic use ; Cyclopropanes ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Alkynes ; Thailand ; Benzoxazines/pharmacokinetics ; Benzoxazines/therapeutic use ; Liver Cirrhosis/drug therapy ; Drug Therapy, Combination ; Benzimidazoles

المؤلفون: Ryu H; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., Kim HC; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., Jeon I; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., Jang IJ; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., Cho JY; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim KT; Addpharma, Inc., Yongin-si, Gyeonggi-do, Republic of Korea., Oh J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.; Department of Pharmacology, Jeju National University College of Medicine, Jeju, Republic of Korea.; Clinical Research Institute, Jeju National University Hospital, Jeju, Republic of Korea.

المصدر: Drug design, development and therapy [Drug Des Devel Ther] 2024 Jul 01; Vol. 18, pp. 2641-2652. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

مواضيع طبية MeSH: Telmisartan*/administration & dosage , Telmisartan*/pharmacokinetics , Rosuvastatin Calcium*/pharmacokinetics , Rosuvastatin Calcium*/administration & dosage , Amlodipine*/pharmacokinetics , Amlodipine*/administration & dosage , Ezetimibe*/administration & dosage , Ezetimibe*/pharmacokinetics , Cross-Over Studies* , Healthy Volunteers* , Drug Combinations*, Humans ; Male ; Adult ; Young Adult ; Benzoates/pharmacokinetics ; Benzoates/administration & dosage ; Benzimidazoles/pharmacokinetics ; Benzimidazoles/administration & dosage ; Dose-Response Relationship, Drug ; Drug Interactions

المؤلفون: Reddiar SB; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia., Abdallah M; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia., Styles IK; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia., Müllertz OO; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Trevaskis NL; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia. Electronic address: Natalie.Trevaskis@monash.edu.

المصدر: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Jul; Vol. 200, pp. 114339. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE

مواضيع طبية MeSH: Exenatide*/pharmacokinetics , Exenatide*/administration & dosage , Exenatide*/pharmacology , Liraglutide*/pharmacology , Liraglutide*/pharmacokinetics , Liraglutide*/administration & dosage , Peptides*/pharmacokinetics , Peptides*/administration & dosage , Rats, Sprague-Dawley*, Animals ; Rats ; Male ; Lipids/chemistry ; Half-Life ; Venoms/pharmacokinetics ; Venoms/administration & dosage ; Biological Availability ; Tissue Distribution ; Injections, Subcutaneous ; Lymph/metabolism ; Lymph/drug effects ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptide 1/pharmacokinetics ; Glucagon-Like Peptide 1/metabolism ; Lymphatic System/metabolism ; Lymphatic System/drug effects ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology

المؤلفون: Kim JH; Clinical Trials Center, Chungnam National University Hospital, 266 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea.; Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Song JH; Clinical Trials Center, Chungnam National University Hospital, 266 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea.; Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Kim M; Pharmaceutical Research and Technology Development Center, Chong Kun Dang Pharmaceutical Corporation, Yongin, Gyeonggi, Republic of Korea., Hong JH; Clinical Trials Center, Chungnam National University Hospital, 266 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea.; Department of Pharmacology, Chungnam National University College of Medicine, Daejeon, Republic of Korea., Sunwoo J; Clinical Trials Center, Chungnam National University Hospital, 266 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea. swj4991@cnuh.co.kr., Jung JG; Department of Family Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea. jjg72@hanmail.net.; Department of Family Medicine, Chungnam National University College of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea. jjg72@hanmail.net.

المصدر: Advances in therapy [Adv Ther] 2024 Jul; Vol. 41 (7), pp. 2808-2825. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article; Randomized Controlled Trial; Comparative Study

بيانات الدورية: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

مواضيع طبية MeSH: Biphenyl Compounds*/pharmacokinetics , Biphenyl Compounds*/administration & dosage , Amlodipine*/pharmacokinetics , Amlodipine*/administration & dosage , Benzimidazoles*/pharmacokinetics , Benzimidazoles*/administration & dosage , Tetrazoles*/pharmacokinetics , Tetrazoles*/administration & dosage , Cross-Over Studies* , Drug Combinations* , Atorvastatin*/pharmacokinetics , Atorvastatin*/administration & dosage, Humans ; Male ; Adult ; Female ; Young Adult ; Area Under Curve ; Middle Aged ; Angiotensin II Type 1 Receptor Blockers/pharmacokinetics ; Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Calcium Channel Blockers/pharmacokinetics ; Calcium Channel Blockers/administration & dosage ; Therapeutic Equivalency ; Antihypertensive Agents/pharmacokinetics ; Antihypertensive Agents/administration & dosage ; Heptanoic Acids/pharmacokinetics ; Heptanoic Acids/administration & dosage ; Healthy Volunteers

المؤلفون: Loos NHC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Bui V; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., de Jong DH; Division of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Lebre MC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Rosing H; Division of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.; Division of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands., Schinkel AH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. a.schinkel@nki.nl.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Jul; Vol. 94 (1), pp. 79-87. Date of Electronic Publication: 2024 Mar 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Ritonavir*/administration & dosage , Ritonavir*/pharmacokinetics , Docetaxel*/administration & dosage , Docetaxel*/pharmacokinetics , Loperamide*/administration & dosage , Loperamide*/pharmacokinetics , Cytochrome P-450 CYP3A*/metabolism , Taxoids*/pharmacokinetics , Taxoids*/administration & dosage , Drug Interactions*, Animals ; Mice ; Administration, Oral ; Humans ; Tissue Distribution ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/administration & dosage ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Area Under Curve ; Antidiarrheals/administration & dosage ; Antidiarrheals/pharmacokinetics ; Mice, Transgenic