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المؤلفون: Markus Zweckstetter, Tiago F. Outeiro, Annekatrin König, Antonio Dominguez-Meijide, Alain Ibáñez de Opakua, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Maria-Sol Cima-Omori, Eftychia Vasili
المصدر: Scientific Reports
Scientific reports 10(1), 12827 (2020). doi:10.1038/s41598-020-69744-y
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, Protein aggregation, therapeutic use [Benzodioxoles], Catechin, 0302 clinical medicine, drug therapy [Alzheimer Disease], therapeutic use [Catechin], metabolism [alpha-Synuclein], Molecular Targeted Therapy, Internalization, lcsh:Science, Cells, Cultured, media_common, pharmacology [Benzopyrans], Multidisciplinary, biology, Chemistry, analogs & derivatives [Catechin], Brain, Neurofibrillary Tangles, Parkinson Disease, 3. Good health, Pharmacological interventions, metabolism [Neurofibrillary Tangles], therapeutic use [Pyrazoles], alpha-Synuclein, pharmacology [Catechin], metabolism [Alzheimer Disease], therapeutic use [Hydrazones], Cell biology, Tau pathology, media_common.quotation_subject, Tau protein, metabolism [Parkinson Disease], pharmacology [Benzodioxoles], tau Proteins, Protein Aggregation, Pathological, Article, pharmacology [Hydrazones], 03 medical and health sciences, Protein Aggregates, metabolism [Protein Aggregation, Pathological], Alzheimer Disease, medicine, Dementia, Humans, Benzopyrans, Benzodioxoles, therapeutic use [Benzopyrans], Lewy body, lcsh:R, Hydrazones, drug effects [Protein Aggregates], medicine.disease, metabolism [Lewy Bodies], drug therapy [Parkinson Disease], metabolism [tau Proteins], 030104 developmental biology, metabolism [Brain], biology.protein, Pyrazoles, α synuclein, lcsh:Q, Lewy Bodies, pharmacology [Pyrazoles], Neuroscience, ddc:600, 030217 neurology & neurosurgery
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https://hdl.handle.net/21.11116/0000-0008-7D9B-E21.11116/0000-0008-7D97-2 -
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المؤلفون: Maximilian Deussing, Matthias Brendel, Paul Cumming, Guido Boening, Finn Peters, Felix Overhoff, Christian Griesinger, Igor Yakushev, Sergey Ryazanov, Johannes Levin, Andreas Zwergal, Andrei Leonov, Barbara von Ungern-Sternberg, Jochen Herms, Lena Kaiser, Armin Giese, Tanja Blume, Peter Bartenstein, Federico Probst, Sibylle Ziegler, Axel Rominger
المصدر: Alzheimer's Research and Therapy
Alzheimer's research & therapy 11(1), 67 (2019). doi:10.1186/s13195-019-0522-z
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Alzheimer's Research & Therapy
Brendel, Matthias; Deussing, Maximilian; Blume, Tanja; Kaiser, Lena; Probst, Federico; Overhoff, Felix; Peters, Finn; von Ungern-Sternberg, Barbara; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Zwergal, Andreas; Levin, Johannes; Bartenstein, Peter; Yakushev, Igor; Cumming, Paul; Boening, Guido; Ziegler, Sibylle; Herms, Jochen; Giese, Armin; ... (2019). Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau. Alzheimer's research & therapy, 11(1), p. 67. BioMed Central 10.1186/s13195-019-0522-z <http://dx.doi.org/10.1186/s13195-019-0522-z>مصطلحات موضوعية: 0301 basic medicine, Neurology, Hippocampus, lcsh:RC346-429, Mice, 0302 clinical medicine, drug therapy [Alzheimer Disease], medicine.diagnostic_test, Neurofibrillary Tangles, 3. Good health, ddc, administration & dosage [Benzodioxoles], metabolism [Neurofibrillary Tangles], Positron emission tomography, Disease Progression, Immunohistochemistry, Female, Tauopathy, metabolism [Alzheimer Disease], Genetically modified mouse, medicine.medical_specialty, Cognitive Neuroscience, 610 Medicine & health, tau Proteins, pharmacology [Benzodioxoles], Mice, Transgenic, Carbohydrate metabolism, lcsh:RC321-571, 03 medical and health sciences, Neuronal injury, Alzheimer Disease, Internal medicine, medicine, administration & dosage [Pyrazoles], Animals, Humans, drug effects [Neurofibrillary Tangles], Benzodioxoles, ddc:610, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Pathological, lcsh:Neurology. Diseases of the nervous system, business.industry, Research, Anle138b, Late-stage, medicine.disease, metabolism [tau Proteins], Disease Models, Animal, 030104 developmental biology, Endocrinology, Positron-Emission Tomography, Small animal PET, Pyrazoles, Neurology (clinical), Tau, business, pharmacology [Pyrazoles], diagnostic imaging [Alzheimer Disease], 030217 neurology & neurosurgery
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https://zenodo.org/record/3360079 -
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المؤلفون: Sergey Ryazanov, Song Shi, Hans A. Kretzschmar, Wolfgang Zinth, Andrei Leonov, Martin Fuhrmann, Carolin Miklitz, Armin Giese, Daniel Weckbecker, Dan Ehninger, Bettina Göricke, Anne Reiner, Julia Steffen, Jens Wagner, Jochen H. Weishaupt, Alexander Kleinknecht, Johannes Levin, Stefan Remy, Christian Griesinger, Sybille Krauss
المصدر: Acta Neuropathologica
Acta neuropathologica 130(5), 619-631 (2015). doi:10.1007/s00401-015-1483-3مصطلحات موضوعية: pathology [Tauopathies], 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, Male, drug effects [Hippocampus], Hippocampus, Protein aggregation, physiology [Cell Death], Frontotemporal dementia and parkinsonism linked to chromosome 17, Synapse, Random Allocation, Tau aggregation inhibitor, pathology [Neurons], drug therapy [Tauopathies], Gliosis, Neurons, Cell Death, Neurodegeneration, pathology [Gliosis], physiology [Neurons], Tauopathy, physiology [Motor Activity], Neuroprotective Agents, Tauopathies, Disease Progression, Female, medicine.symptom, drug effects [Recognition, Psychology], Alzheimer’s disease, Mapt protein, mouse, Genetically modified mouse, physiology [Recognition, Psychology], Clinical Neurology, pharmacology [Benzodioxoles], MAPT protein, human, Mice, Transgenic, tau Proteins, Biology, Motor Activity, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Protein Aggregates, mental disorders, medicine, drug effects [Neurons], Animals, ddc:610, Benzodioxoles, Original Paper, pharmacology [Neuroprotective Agents], drug effects [Motor Activity], Anle138b, drug effects [Protein Aggregates], drug effects [Cell Death], Recognition, Psychology, medicine.disease, physiopathology [Gliosis], metabolism [tau Proteins], genetics [tau Proteins], Disease Models, Animal, pathology [Hippocampus], drug therapy [Gliosis], physiopathology [Hippocampus], Pyrazoles, Neurology (clinical), Tau, pharmacology [Pyrazoles], Neuroscience
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المؤلفون: Roland Benz, Martin Fuhrman, Hope Y Agbemenyah, Joon Lee, Lalit Kaurani, Gregor Eichele, Markus Zweckstetter, Gaurav Jain, Nasrollah Rezaei-Ghaleh, Andre Fischer, Alan L. Gillman, Gayane Grigorian, Ratnesh Lal, Sergey Ryazanov, Mario Caruana, Armin Giese, Christian Griesinger, Martin Korte, Eva Benito, Angelique Camilleri, Andrei Leonov, Neville Vassallo, Jens Wagner, Fernando Teran Arce, Hendrik Urbanke, Ana Martinez Hernandez, Anja Schneider, Petra Wilken
المصدر: EMBO Molecular Medicine
EMBO molecular medicine 10(1), 32-47 (2018). doi:10.15252/emmm.201707825
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2018)
EMBO molecular medicine
EMBO molecular medicine, vol 10, iss 1مصطلحات موضوعية: 0301 basic medicine, Male, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, Medicine (General), drug effects [Hippocampus], Hippocampus, genetics [Alzheimer Disease], metabolism [Hippocampus], Disease, Hippocampal formation, QH426-470, therapeutic use [Benzodioxoles], Inbred C57BL, Medical and Health Sciences, Transcriptome, Mice, 0302 clinical medicine, drug effects [Neuronal Plasticity], drug therapy [Alzheimer Disease], genetics [Amyloid beta-Peptides], Amyloid beta-protein, Spatial Memory, Neuronal Plasticity, Alzheimer's disease -- Pathophysiology, membrane pores, Biological Sciences, Alzheimer's disease, Phenotype, 3. Good health, Alzheimer's disease -- Treatment, drug effects [Transcriptome], therapeutic use [Pyrazoles], Molecular Medicine, drug effects [Spatial Memory], A beta channels, metabolism [Alzheimer Disease], metabolism [Amyloid beta-Peptides], pharmacology [Benzodioxoles], Aβ channels, physiopathology [Alzheimer Disease], 03 medical and health sciences, R5-920, Alzheimer Disease, Neuroplasticity, medicine, Genetics, Dementia, Animals, ddc:610, Benzodioxoles, Amyloid beta-Peptides, business.industry, Animal, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Alzheimers disease, Plaque, amyloid -- Physiopathology, Disease Models, physiopathology [Hippocampus], gene expression, Pyrazoles, amyloid pathology, business, pharmacology [Pyrazoles], Neuroscience, 030217 neurology & neurosurgery, Nervous system -- Degeneration
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المؤلفون: Jens Wagner, Gerda Mitteregger-Kretzschmar, Song Shi, Andrei Leonov, Christian Griesinger, Armin Giese, Sergey Ryazanov
المصدر: Journal of neuropathology and experimental neurology 74(9), 924-933 (2015). doi:10.1097/NEN.0000000000000233
Journal of Neuropathology and Experimental Neurologyمصطلحات موضوعية: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, Pathology, medicine.medical_specialty, PrPSc Proteins, animal diseases, Urinary system, pharmacology [Benzodioxoles], Disease, therapeutic use [Benzodioxoles], Protein aggregation, Biology, Pathology and Forensic Medicine, Prion Diseases, Cellular and Molecular Neuroscience, Mice, Cerebrospinal fluid, pathology [Brain], medicine, Animals, ddc:610, Benzodioxoles, methods [Drug Monitoring], drug therapy [Prion Diseases], urine [Prion Diseases], Neurodegeneration, Brain, General Medicine, urine [PrPSc Proteins], medicine.disease, nervous system diseases, PrP 27-30 Protein, urine [PrP 27-30 Protein], Neurology, metabolism [Brain], Immunology, therapeutic use [Pyrazoles], Pyrazoles, drug effects [Brain], Neurology (clinical), Alzheimer's disease, Drug Monitoring, pharmacology [Pyrazoles], metabolism [Prion Diseases], Biomarkers, urine [Biomarkers]
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https://pubmed.ncbi.nlm.nih.gov/26247395
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