المؤلفون: Ballatore, Carlo, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M-Y, Smith, Amos B

المصدر: ACS Chemical Neuroscience. 8(1)

مصطلحات موضوعية: Aging, Neurosciences, Neurodegenerative, Brain Disorders, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Neurological, Alzheimer Disease, Animals, Biological Products, Central Nervous System, Drug Delivery Systems, Humans, Microtubules, Neurodegenerative Diseases, Microtubule, small molecule microtubule-stabilizing agents, Alzheimer's disease, brain tumor, traumatic brain injury, neurodegenerative disease, triazolopyrimidine, phenylpyrimidine, Alzheimer’s disease, Medicinal and Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9cd5n7pp

المؤلفون: Jin, Bo^{Aff1, Aff2}, Tao, Ye, Yang, Hongliang^{Aff1, Aff2}

المصدر: Chemical Research in Chinese Universities. 34(6):912-917

المؤلفون: Du, Zhijun, Gao, Lianxun, Lin, Yingjie

المصدر: Chemical Research in Chinese Universities. April 2015 31(2):167-170

المؤلفون: Shan Xu, Chengyu Sun, Chen Chen, Pengwu Zheng, Yong Zhou, Hongying Zhou, Wufu Zhu

المصدر: Molecules, Vol 22, Iss 2, p 310 (2017)

مصطلحات موضوعية: imidazopyrazine, phenylpyridine-carboxamide, phenylpyrimidine-carboxamide, PI3Kα, synthesis, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/22/2/310; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/14361d87c26248bea07d9a49a912a4f0

المؤلفون: Huimin Liu, Wenhui Wang, Chengyu Sun, Caolin Wang, Wufu Zhu, Pengwu Zheng

المصدر: Molecules, Vol 21, Iss 11, p 1447 (2016)

مصطلحات موضوعية: thiopyrano[4,3-d]pyrimidine, phenylpyridine/phenylpyrimidine carboxamides, synthesis, cytotoxicity activity, PI3Kα kinase, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/21/11/1447; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d8de94e3b20a46a8a4a522cea8ae3d40

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المؤلفون: Kurt R. Brunden, Virginia M.-Y. Lee, John Q. Trojanowski, Carlo Ballatore, Amos B. Smith

المصدر: ACS chemical neuroscience, vol 8, iss 1

مصطلحات موضوعية: Central Nervous System, 0301 basic medicine, Aging, Physiology, Disease, Neurodegenerative, Microtubules, Biochemistry, Drug Delivery Systems, neurodegenerative disease, 0302 clinical medicine, 2.1 Biological and endogenous factors, small molecule microtubule-stabilizing agents, Aetiology, Amyotrophic lateral sclerosis, triazolopyrimidine, Drug discovery, traumatic brain injury, Neurodegenerative Diseases, General Medicine, Frontotemporal lobar degeneration, Alzheimer's disease, Small molecule, medicine.anatomical_structure, 5.1 Pharmaceuticals, Neurological, Development of treatments and therapeutic interventions, Alzheimer’s disease, brain tumor, Cognitive Neuroscience, Central nervous system, Brain tumor, Microtubule, Biology, Article, Medicinal and Biomolecular Chemistry, 03 medical and health sciences, Alzheimer Disease, medicine, Animals, Humans, Biological Products, Neurosciences, Cell Biology, medicine.disease, Brain Disorders, 030104 developmental biology, phenylpyrimidine, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a026808e777edd2fa0b7c7c96948142a
https://doi.org/10.1021/acschemneuro.6b00384

المؤلفون: Caolin Wang, Chengyu Sun, Huimin Liu, Pengwu Zheng, Wufu Zhu, Wenhui Wang

المصدر: Molecules
Molecules; Volume 21; Issue 11; Pages: 1447
Molecules, Vol 21, Iss 11, p 1447 (2016)

مصطلحات موضوعية: Morpholino, Pyrimidine, synthesis, medicine.drug_class, Stereochemistry, thiopyrano[4,3-d]pyrimidine, phenylpyridine/phenylpyrimidine carboxamides, cytotoxicity activity, PI3Kα kinase, Pharmaceutical Science, Carboxamide, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Neoplasms, Drug Discovery, Ic50 values, medicine, Humans, Physical and Theoretical Chemistry, Cytotoxicity, Biological evaluation, Thiopyran, 010405 organic chemistry, Cytotoxins, Aryl, Organic Chemistry, Imidazoles, 0104 chemical sciences, chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, MCF-7 Cells, Molecular Medicine, Drug Screening Assays, Antitumor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a9360a6cc44d620522f87fd2bc2ece
http://europepmc.org/articles/PMC6273168

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المؤلفون: Hongying Zhou, Chen Chen, Chengyu Sun, Pengwu Zheng, Wufu Zhu, Shan Xu, Yong Zhou

المصدر: Molecules, Vol 22, Iss 2, p 310 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 2; Pages: 310

مصطلحات موضوعية: PI3Kα, synthesis, Pyrazine, Pyridines, Stereochemistry, imidazopyrazine, phenylpyridine-carboxamide, phenylpyrimidine-carboxamide, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Molecular Dynamics Simulation, Ring (chemistry), 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Cell Line, Tumor, Drug Discovery, Pyridine, Humans, Physical and Theoretical Chemistry, Benzene, Cytotoxicity, IC50, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, 010405 organic chemistry, Kinase, Aryl, Organic Chemistry, 0104 chemical sciences, Molecular Docking Simulation, Pyrimidines, chemistry, Chemistry (miscellaneous), Pyrazines, 030220 oncology & carcinogenesis, Molecular Medicine, Protein Binding, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a87c51073057e35d058c568d06788b6
https://doi.org/10.3390/molecules22020310