المؤلفون: Li H; Institute of Precision Drug Innovation and Cancer Center, the Second Hospital of Dalian Medical University, Dalian, 116023, China.; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.; Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University, Chengdu, 610041, China., Wen X; Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University, Chengdu, 610041, China., Ren Y; Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University, Chengdu, 610041, China.; Department of Brain Science, Faculty of Medicine, Imperial College, London, SW72AZ, UK., Fan Z; Institute of Precision Drug Innovation and Cancer Center, the Second Hospital of Dalian Medical University, Dalian, 116023, China.; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.; Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University, Chengdu, 610041, China., Zhang J; School of Pharmaceutical Sciences of Medical School, Shenzhen University, Shenzhen, 518000, China. zhangjin1989@szu.edu.cn., He G; Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University, Chengdu, 610041, China. hegu@scu.edu.cn., Fu L; Institute of Precision Drug Innovation and Cancer Center, the Second Hospital of Dalian Medical University, Dalian, 116023, China. leilei_fu@163.com.; Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. leilei_fu@163.com.

المصدر: Molecular cancer [Mol Cancer] 2024 Aug 10; Vol. 23 (1), pp. 164. Date of Electronic Publication: 2024 Aug 10.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Molecular Targeted Therapy* , Signal Transduction*/drug effects, Humans ; Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Bastos IM; LAQV-REQUIMTE and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal., Rebelo S; Institute of Biomedicine-iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal., Silva VLM; LAQV-REQUIMTE and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: verasilva@ua.pt.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2024 Aug 01; Vol. 398, pp. 111073. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Indazoles*/chemistry , Indazoles*/pharmacology , Indazoles*/therapeutic use , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/therapeutic use , Neoplasms*/drug therapy , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinase/metabolism ; Signal Transduction/drug effects

المؤلفون: Karvonen H; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Vasan N; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA; Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY, USA. Electronic address: nv2379@cumc.columbia.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2024 Jul 18; Vol. 31 (7), pp. 1244-1246.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Leukemia*/drug therapy , Leukemia*/pathology , Leukemia*/metabolism , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use, Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry

المؤلفون: Yin X; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Wang J; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Ge M; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China., Feng X; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China., Zhang G; Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, People's Republic of China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10530-10547. Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Class Ib Phosphatidylinositol 3-Kinase*/metabolism , Class Ib Phosphatidylinositol 3-Kinase*/chemistry , Drug Design* , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/chemical synthesis, Humans ; Structure-Activity Relationship ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Animals ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Molecular Structure

المؤلفون: Bruno P; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Micoli A; Drug Discovery Chemistry Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy., Corsi M; In Vitro Biology Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy., Pala D; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Guariento S; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Fiorelli C; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Ronchi P; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Fioni A; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Gallo PM; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Marenghi G; Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Bertolini S; Pharmacology Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Capacchi S; Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Mileo V; Analytics & Early Formulations Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Biagetti M; Pipeline Innovation Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy., Capelli AM; AIR Franchise, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11103-11124. Date of Electronic Publication: 2024 Jun 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/pharmacokinetics , Phosphoinositide-3 Kinase Inhibitors*/chemical synthesis , Pyridazines*/chemistry , Pyridazines*/pharmacology , Pyridazines*/pharmacokinetics , Pyridazines*/chemical synthesis , Class I Phosphatidylinositol 3-Kinases*/antagonists & inhibitors , Class I Phosphatidylinositol 3-Kinases*/metabolism, Animals ; Humans ; Administration, Inhalation ; Structure-Activity Relationship ; Drug Discovery ; Rats ; Mice ; Male ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/administration & dosage

المؤلفون: Kashani B; Hematology, Oncology and Stem Cell Transplantation Research Center, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Zandi Z; Hematology, Oncology and Stem Cell Transplantation Research Center, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Pourbagheri-Sigaroodi A; Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yousefi AM; Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghaffari SH; Hematology, Oncology and Stem Cell Transplantation Research Center, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Bashash D; Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

المصدر: Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2024 Jul; Vol. 24 (7), pp. 493-512. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101123358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8328 (Electronic) Linking ISSN: 14737140 NLM ISO Abbreviation: Expert Rev Anticancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction* , Phosphatidylinositol 3-Kinases*/metabolism , Lymphopoiesis* , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/administration & dosage , Lymphoma*/pathology , Lymphoma*/drug therapy , Drug Development*, Humans ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Disease Progression ; Molecular Targeted Therapy ; Drug Design ; Cell Differentiation

المؤلفون: Ibanez KR; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Huang TT; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Lee JM; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

المصدر: Cells [Cells] 2024 Jun 19; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Genital Neoplasms, Female*/drug therapy , Genital Neoplasms, Female*/genetics , Genital Neoplasms, Female*/pathology , Drug Resistance, Neoplasm*/drug effects , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Signal Transduction*/drug effects, Humans ; Female ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Animals

المؤلفون: Yu M; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Wang X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Tang Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Wang L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Hu X; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, China., Weng Q; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; Taizhou Institute of Zhejiang University, Taizhou 318000, China., Wang J; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Cui S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 9628-9644. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Multiple Sclerosis*/drug therapy , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemical synthesis , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Encephalomyelitis, Autoimmune, Experimental*/drug therapy , Class I Phosphatidylinositol 3-Kinases*/antagonists & inhibitors , Class I Phosphatidylinositol 3-Kinases*/metabolism , Indoles*/pharmacology , Indoles*/chemistry , Indoles*/chemical synthesis , Indoles*/therapeutic use, Animals ; Humans ; Mice ; Cell Proliferation/drug effects ; Aza Compounds/chemistry ; Aza Compounds/pharmacology ; Aza Compounds/chemical synthesis ; Structure-Activity Relationship ; T-Lymphocytes/drug effects ; Drug Discovery ; Mice, Inbred C57BL ; Female ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Yevale D; Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China; Department of Chemistry, Shri M.M Patel Institute of Sciences and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382016, Gujarat, India., Teraiya N; Department of Pharmaceutical Chemistry, K B Institute of Pharmaceutical Education and Research, Kadi Sarva Vishvavidhyalay, Gandhinagar, Gujarat 382023, India., Lalwani T; Piramal Pharma Limited, Plot No. 18, Pharmaceutical Special Economic Zone, Village-Matoda, Taluka- Sanand, Ahmedabad 382213, Gujarat, India., Dalasaniya M; Piramal Pharma Limited, Plot No. 18, Pharmaceutical Special Economic Zone, Village-Matoda, Taluka- Sanand, Ahmedabad 382213, Gujarat, India., Kapadiya K; BRCC Laboratory, Department of Chemistry, School of Science, RK University, Rajkot 360 020, Gujarat, India., Ameta RK; Department of Chemistry, Shri M.M Patel Institute of Sciences and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382016, Gujarat, India., Sangani CB; Department of Chemistry, Shri M.M Patel Institute of Sciences and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382016, Gujarat, India; Department of Chemistry, Government Science College Sector-15, Gandhinagar-382016, Gujarat University, Gujarat, India. Electronic address: chetansangani1986@yahoo.com., Duan YT; Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China. Electronic address: duanyongtao860409@163.com.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107323. Date of Electronic Publication: 2024 Mar 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , TOR Serine-Threonine Kinases*/antagonists & inhibitors , TOR Serine-Threonine Kinases*/metabolism , Drug Design* , Drug Screening Assays, Antitumor* , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/chemical synthesis , Phosphoinositide-3 Kinase Inhibitors*/chemistry , Cell Proliferation*/drug effects , Dose-Response Relationship, Drug* , Quinolines*/pharmacology , Quinolines*/chemistry , Quinolines*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; MTOR Inhibitors/pharmacology ; MTOR Inhibitors/chemical synthesis ; MTOR Inhibitors/chemistry ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases/metabolism

المؤلفون: Moein A; Faculty of Pharmaceutical Sciences, University of British Columbia, Office 5505, Pharmaceutical Sciences Building, Vancouver, BC, Canada.; Genentech, Inc., South San Francisco, CA, USA., Jin JY; Genentech, Inc., South San Francisco, CA, USA., Wright MR; Genentech, Inc., South San Francisco, CA, USA., Alicke B; Genentech, Inc., South San Francisco, CA, USA., Wong H; Faculty of Pharmaceutical Sciences, University of British Columbia, Office 5505, Pharmaceutical Sciences Building, Vancouver, BC, Canada. harvey.wong@ubc.ca.

المصدر: Drugs in R&D [Drugs R D] 2024 Jun; Vol. 24 (2), pp. 155-167. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 100883647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-6901 (Electronic) Linking ISSN: 11745886 NLM ISO Abbreviation: Drugs R D Subsets: MEDLINE

مواضيع طبية MeSH: Phosphoinositide-3 Kinase Inhibitors*/pharmacokinetics , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , MTOR Inhibitors*/therapeutic use , MTOR Inhibitors*/pharmacology , MTOR Inhibitors*/pharmacokinetics , Xenograft Model Antitumor Assays*, Humans ; Animals ; Mice ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Retrospective Studies ; Female ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Models, Biological ; Kidney Neoplasms/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Phosphatidylinositol 3-Kinases/metabolism ; Neoplasms/drug therapy ; Cell Line, Tumor ; Carcinoma, Renal Cell/drug therapy