نتائج البحث - "pimasertib"

المصدر: Acta ophthalmologica, 96(7), 712-718. Copenhagen Scriptor
Acta Ophthalmologica, 96(7), 712-718
Acta Ophthalmologica, 96(7), 712-718. Wiley-Blackwell Publishing Ltd

مصطلحات موضوعية: Male, Visual acuity, Skin Neoplasms, genetic structures, Visual Acuity, pimasertib, 0302 clinical medicine, Medicine, Prospective Studies, Fluorescein Angiography, Melanoma, Color Perception Tests, medicine.diagnostic_test, MEK inhibitor, Subretinal Fluid, General Medicine, Diabetic retinopathy, Middle Aged, Fluorescein angiography, serous retinopathy, Visual field, ophthalmological adverse events, Serous fluid, retinal vein occlusion, 030220 oncology & carcinogenesis, Female, medicine.symptom, Tomography, Optical Coherence, Retinopathy, Niacinamide, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, Antineoplastic Agents, 03 medical and health sciences, Retinal Diseases, Ophthalmology, Humans, Protein Kinase Inhibitors, Intraocular Pressure, Aged, business.industry, Fundus photography, medicine.disease, eye diseases, Ophthalmoscopy, mitogen-activated protein kinase kinase inhibitor, Cross-Sectional Studies, 030221 ophthalmology & optometry, sense organs, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0ec930ad9e0d8d6dacfd29d071ab25
https://doi.org/10.1111/aos.13677

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8

Phase I single dose, two-period and two-sequence cross-over trial to evaluate the relative bioavailability of two oral pimasertib formulations in advanced cancer patients

المؤلفون: Srinath Sundararajan, Rebecca S. Heist, Donald A. Richards, Monica M. Mita, Aung Naing, Abhijeet Kumar, Daruka Mahadevan, Edward McClay

المصدر: Cancer Chemotherapy and Pharmacology. 79:681-688

مصطلحات موضوعية: Adult, Male, Niacinamide, 0301 basic medicine, Cancer Research, medicine.medical_specialty, MAP Kinase Signaling System, Drug Compounding, Biological Availability, Antineoplastic Agents, Capsules, Pharmacology, Toxicology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Humans, Medicine, Pimasertib, Pharmacology (medical), Adverse effect, Protein Kinase Inhibitors, Aged, Cross-Over Studies, biology, business.industry, Capsule, PK Parameters, Middle Aged, Advanced cancer, Crossover study, Bioavailability, Treatment Outcome, 030104 developmental biology, Oncology, Area Under Curve, 030220 oncology & carcinogenesis, biology.protein, Female, Creatine kinase, business, Tablets

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c680dca35a2a178dd267f9519a4d03
https://doi.org/10.1007/s00280-017-3258-0

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9

Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors

المؤلفون: Monica M. Mita, Filip Janku, Ronald B. Natale, Aung Naing, Wei Guo, Razelle Kurzrock, Siqing Fu, Sarina Anne Piha-Paul, Alain C. Mita, C. Zhao

المصدر: Investigational New Drugs. 35:616-626

مصطلحات موضوعية: Adult, Male, Niacinamide, 0301 basic medicine, MAPK/ERK pathway, Maximum Tolerated Dose, MAP Kinase Kinase Kinase 1, MAP Kinase Kinase Kinase 2, Pharmacology, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Stable Disease, Refractory, Pharmacokinetics, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pimasertib, Pharmacology (medical), Adverse effect, Protein Kinase Inhibitors, Stomatitis, Aged, Aged, 80 and over, Sirolimus, business.industry, TOR Serine-Threonine Kinases, Middle Aged, medicine.disease, Temsirolimus, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6f1cae671876d1b4d3af544b954972
https://doi.org/10.1007/s10637-017-0442-3

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10

Phase I trial of pimasertib monotherapy in Japanese patients with solid tumors and those with hepatocellular carcinoma

المؤلفون: Masataka Ikeda, Kentaro Yamazaki, Takuji Okusaka, A Ohtsu, A Schueler, Toshihiko Doi, M Watanabe

المصدر: Cancer chemotherapy and pharmacology. 84(5)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Niacinamide, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Maximum Tolerated Dose, Toxicology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Neoplasms, medicine, Pimasertib, Humans, Pharmacology (medical), In patient, Adverse effect, Stomatitis, Protein Kinase Inhibitors, Aged, Pharmacology, Dose-Response Relationship, Drug, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, digestive system diseases, Hypokalemia, Diarrhea, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Toxicity, Female, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edc217547ac14e708a0d23dab6a9785
https://pubmed.ncbi.nlm.nih.gov/31482223

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