يعرض 1 - 10 نتائج من 129 نتيجة بحث عن '"protein bcl 2"', وقت الاستعلام: 1.14s تنقيح النتائج
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    دورية أكاديمية

    المصدر: Molecular cancer therapeutics. 7(12)

    وصف الملف: application/pdf

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    المساهمون: Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü., Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., İçsel, Ceyda, Aydınlık, Şeyma, Yılmaz, Veysel Turan, ABI-2909-2020, AAI-3342-2021, 2-s2.0-85087758658

    مصطلحات موضوعية: Cell viability, Protein bcl 2, Pyridines, Coordination complexes, Apoptosis, Manganese, IC50, Targeting mitochondria, 01 natural sciences, Anticancer activity, Saccharin, Chemical structure, Drug Discovery, Antineoplastic agents, 2,6-bis(benzimidazol-2-yl)pyridine, Enzyme activity, Vivtro DNA-binding, Pyridine derivative, Cell proliferation, Saccharin derivative, chemistry.chemical_classification, 0303 health sciences, Structure activity relation, General Medicine, Manganese derivative, Antineoplastic agent, Drug screening, Molecular docking, Dose-response relationship, drug, Cell membrane depolarization, Drug stability, Human, Saccharinate, Double-strand breaks, Article, Tumor cell culture, Metal, 03 medical and health sciences, Drug synthesis, Pyridine, Dose response, Humans, Pharmacology, Cisplatin, 010405 organic chemistry, Pharmacology & pharmacy, Tumor cells, cultured, Copper, 0104 chemical sciences, Drug effect, Human cell, Oxidative stress, Benzimidazoles, 2,6 bis(2 benzimidazolyl)pyridine derivative, Unclassified drug, Enzyme activation, Antiproliferative activity, MCF-7 cell line, Cobalt complex, Cell survival, chemistry.chemical_compound, Nickel complex, Synthesis, Protein expression level, Iron complex, Caspase 7, DNA cleavage, HT-29 cell line, Chemistry, Caspase 3, Copper complex, Cancer-cells, Ligand cu(II) complexes, Plasmid DNA, Double stranded DNA break, Drug screening assays, antitumor, Heavy metal, visual_art, A-549 cell line, visual_art.visual_art_medium, Tumor necrosis factor receptor superfamily member 6, Chemistry, medicinal, Cobalt, Coordination compound, medicine.drug, Drug cytotoxicity, chemistry.chemical_element, Antineoplastic metal complex, MCF-10A cell line, G1 phase cell cycle checkpoint, 2,6-Bis(2-benzimidazolyl)pyridine, medicine, Benzimidazole derivative, DNA binding, Mitochondrion, 030304 developmental biology, Antineoplastic activity, Hydrogen bond, Reactive oxygen species, Cytotoxic activity, Protein Bax, Organic Chemistry, In vitro study, Structure-activity relationship, Complex, Palladium, 2-Phenylpyridine, Cell-cycle, Metals, heavy, Nickel, Ray crystal-structure, Structural-characterization, Molecular structure, Reactive oxygen metabolite, Controlled study, Nuclear chemistry, First row divalent transition metals, Mitochondrial membrane

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    مصطلحات موضوعية: Chalcone, SnoRNA, Epithelial-Mesenchymal Transition, Angiogenesis, Apoptosis, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Chalcones, Downregulation and upregulation, Cell Movement, Cell Line, Tumor, Drug Discovery, Humans, 030304 developmental biology, Cell Proliferation, Pharmacology, 0303 health sciences, 1 [4 (methylsulfonyl)phenyl] 3 (2,4,6 trimethoxyphenyl)prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 (2,4,6 trimethoxyphenyl)prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 [3 (trifluoromethyl)phenyl]prop 2 en 1 one, 3 (2 methoxyphenyl) 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, 3 (2,5 dimethoxyphenyl) 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, 3 (6 bromobenzo[d][1,3]dioxol 5 yl) 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, 3 (6 bromobenzo[d][1,3]dioxol 5 yl) 1 [4 (methylthio)phenyl]prop 2 en 1 one, 3 (6 bromobenzo[d][1,3]dioxol 5 yl) 1 [4 (piperazin 1 yl)phenyl]prop 2 en 1 one, 3 (benzo[b]thiophen 2 yl) 1 (3 methoxyphenyl)prop 2 en 1 one, 3 (benzo[b]thiophen 2 yl) 1 (3,4,5 trimethoxyphenyl)prop 2 en 1 one, 3 (benzo[b]thiophen 2 yl) 1 (benzo[d][1,3]dioxol 5 yl)prop 2 en 1 one, 3 (benzo[b]thiophen 2 yl) 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, 3 (benzo[b]thiophen 2 yl) 1 [4 (methylthio)phenyl]prop 2 en 1 one, 3 [2 fluoro 4 (trifluoromethyl)phenyl] 1 [4 (methylthio)phenyl]prop 2 en 1 one, antineoplastic agent, B Raf kinase, beta catenin, chalcone derivative, fascin, paclitaxel, protein Bax, protein bcl 2, unclassified drug, uvomorulin, vimentin, KRAS protein, human, protein p21, antiangiogenic activity, antineoplastic activity, apoptosis, Article, BRAF gene, cancer inhibition, cell adhesion, cell cycle, cell viability, colony formation, colorectal cancer, controlled study, down regulation, drug design, drug effect, drug efficacy, drug potency, drug potentiation, drug screening, drug selectivity, drug synthesis, epithelial mesenchymal transition, gene mutation, GI50, HCT 116 cell line, HT-29 cell line, immortalized cell line, in vitro study, in vivo study, LoVo cell line, metastasis, migration inhibition, oncogene K ras, priority journal, proapoptotic activity, process optimization, tumor invasion, tumor suppressor gene, tumor vascularization, upregulation, cell motion, cell proliferation, chemistry, colorectal tumor, genetics, human, tumor cell line, Colorectal Neoplasms, SARS-CoV-2, COVID-19, Cell migration, Cell cycle, digestive system diseases, Cell culture, 030220 oncology & carcinogenesis, Catenin, Cancer cell, Cancer research, MiRNA, Biomarkers

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    المصدر: European journal of medicinal chemistry. 187

    مصطلحات موضوعية: Models, Molecular, Chalcone, Cell cycle checkpoint, Cell Survival, Nitrogen, Mice, Nude, Cancer progression, Apoptosis, Triple Negative Breast Neoplasms, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 1 (3 chlorophenyl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 (3 methoxyphenyl) 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 (3 methoxyphenyl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 (benzo[d][1,3]dioxol 5 yl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 (4 morpholinophenyl)prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylthio)phenyl) 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 (4 morpholinophenyl)prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 3 (4 morpholinophenyl) 1 [4 (piperazin 1 yl) phenyl)prop 2 en 1 one, 3 [4 [bis(2 chloroethyl)amino]phenyl] 1 (2 methoxyphenyl)prop 2 en 1 one, 3 [4 [bis(2 chloroethyl)amino]phenyl] 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, antineoplastic agent, chalcone derivative, chlormethine, colchicine, estrogen, morpholine, P cadherin, paclitaxel, piperidine derivative, protein Bax, protein bcl 2, pyrrolidine derivative, unclassified drug, uvomorulin, vasculotropin receptor 2, [3 [4 [bis(2 chloroethyl)amino]phenyl] 1 (3 methoxyphenyl)prop 2 en 1 one], chalcone, nitrogen, angiogenesis, animal cell, animal experiment, animal model, antineoplastic activity, antiproliferative activity, apoptosis, Article, cancer inhibition, cell invasion, cell migration, chorioallantois, clinical effectiveness, clinical evaluation, colony formation, comparative study, concentration response, controlled study, cytotoxicity, down regulation, drug design, drug efficacy, drug identification, drug synthesis, epithelial mesenchymal transition, G2 phase cell cycle checkpoint, human, human cell, IC50, in vivo study, MCF-7 cell line, MDA-MB-231 cell line, MDA-MB-468 cell line, mouse, nonhuman, triple negative breast cancer, tumor xenograft, upregulation, animal, cell cycle checkpoint, cell proliferation, cell survival, chemical structure, chemistry, dose response, drug effect, drug screening, experimental mammary neoplasm, female, molecular model, nude mouse, pathology, structure activity relation, synthesis, tumor cell culture, Animals, Cell Cycle Checkpoints, Cell Proliferation, Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Female, Humans, Mammary Neoplasms, Experimental, Molecular Structure, Tumor Cells, Cultured, Nude mouse, Drug Discovery, Epithelial–mesenchymal transition, Triple-negative breast cancer, 030304 developmental biology, Pharmacology, E-cadherin/catenin complex and its signaling pathways, 0303 health sciences, biology, 010405 organic chemistry, Oral cancer, Organic Chemistry, Emt, General Medicine, biology.organism_classification, Nitrogen mustard, 0104 chemical sciences, Cell culture, Cancer research

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    المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., Cevatemre, Buse, Erkısa, Merve, Aztopal, Nazlıhan, Karakaş, Didem, Alper, Pınar, AHD-2050-2022, AAM-1001-2020, L-6687-2018, L-6682-2018, İstinye Üniversitesi, Rektörlük, Didem Karakaş / 0000-0002-3781-6834, Engin Ulukaya / 0000-0003-4875-5472, Merve Erkısa Genel / 0000-0002-3127-742X, Pınar Alper / 0000-0001-9631-3551, Erkisa Genel, Merve, Karakaş Zeybek, Didem, Ulukaya, Engin, Didem Karakaş / L-6682-2018, Engin Ulukaya / K-5792-2018, Merve Erkısa Genel / AAM-1001-2020, Pınar Alper / DUL-1586-2022, Didem Karakaş / 56422040600, Engin Ulukaya / 6602927353, Merve Erkısa Genel / 57126208900, Pınar Alper / 57197858774

    المصدر: Pharmacological Research. 129:500-514

    مصطلحات موضوعية: 0301 basic medicine, Palladium(ıı), Protein bcl 2, Unclassified drug, Mouse, Proliferation, Enzyme activation, Apoptosis, Antiproliferative activity, IC50, MCF-7 cell line, Experimental mammary neoplasm, Cell vacuole, Animal tissue, Metastasis, Western blotting, Biological product, Unfolded protein response, Degradation, Mice, In vivo study, Breast cancer, 0302 clinical medicine, Antineoplastic agents, Cytotoxic T cell, Flow cytometry, Priority journal, Caspase 7, education.field_of_study, Signaling pathway, Caspase 3, Chemistry, Neoplastic stem cells, Antineoplastic agent, Protein cleavage, Drug screening, Sesquiterpene, Pristimerin, Maytenus, 030220 oncology & carcinogenesis, Sequestosome 1, cytoplasmic vacuolation, endoplasmic reticulum stress, Female, triterpenoid, Stem cell, Pentacyclic Triterpenes, Animal cell, Drug mechanism, Xenograft model antitumor assays, Human, Drug cytotoxicity, Programmed cell death, Microtubule associated protein, Microtubule associated protein 1A 1B light chain 3B, mammosphere, Population, Article, 03 medical and health sciences, Cancer stem cell, Autophagy, Animals, Humans, Animal model, Drug dose comparison, Biological products, Animal experiment, ATPase activity assay, education, Antineoplastic activity, Pharmacology, Pharmacology & pharmacy, Animal, Carcinoma, In vitro study, Tumor cell line, Nonhuman, Triterpenes, Mammary neoplasms, experimental, Drug effect, Drug efficacy, Cell line, tumor, 030104 developmental biology, Human cell, Doxorubicin, Cancer cell, Cancer research, Protein expression, Tumor xenograft, Triterpene, Controlled study, Phosphatidylinositol 3 kinase

    وصف الملف: application/pdf

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    المصدر: International Journal of Medicinal Mushrooms. 20:1075-1086