المؤلفون: Healy LD; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Fernández JA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Aiolfi R; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Mosnier LO; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Griffin JH; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA. Electronic address: jgriffin@scripps.edu.

المصدر: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Jul; Vol. 22 (7), pp. 2039-2051. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE

مواضيع طبية MeSH: Protein C*/metabolism , Protein C*/chemistry , Receptor, PAR-1*/agonists , Receptor, PAR-1*/metabolism , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects, Humans ; Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Mice, Inbred C57BL ; THP-1 Cells ; Thrombin/metabolism ; Endothelial Protein C Receptor/metabolism ; Receptors, Thrombin/agonists ; Receptors, Thrombin/metabolism ; Signal Transduction ; Receptors, Proteinase-Activated/agonists ; Receptors, Proteinase-Activated/metabolism ; Peptides/pharmacology ; Peptides/chemistry ; Endotoxemia/drug therapy ; Endotoxemia/metabolism ; Peptide Fragments/pharmacology ; Male ; Disease Models, Animal

المؤلفون: Cirovic A; Center of Bone Biology, Institute of Anatomy, University of Belgrade - Faculty of Medicine, Dr Subotica 4/2, Belgrade, Serbia., Djuric M; Center of Bone Biology, Institute of Anatomy, University of Belgrade - Faculty of Medicine, Dr Subotica 4/2, Belgrade, Serbia., Milovanovic P; Center of Bone Biology, Institute of Anatomy, University of Belgrade - Faculty of Medicine, Dr Subotica 4/2, Belgrade, Serbia. drpmilovanovic@gmail.com.

المصدر: Endocrine [Endocrine] 2024 Aug; Vol. 85 (2), pp. 558-565. Date of Electronic Publication: 2024 Mar 14.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE

مواضيع طبية MeSH: Osteoporosis*/etiology , Protein C Deficiency*/complications , Protein S Deficiency*/complications, Humans ; Protein C/metabolism ; Bone Density ; Animals ; Protein S/metabolism

المؤلفون: Siddiqui U; Department of Bioscience, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India., Khan AB; Department of Bioscience, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India., Ahmad T; Department of Bioscience, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India., Rehman AA; Department of Bioscience, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India., Jairajpuri MA; Department of Bioscience, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: mjairajpuri@jmi.ac.in.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 266 (Pt 2), pp. 131065. Date of Electronic Publication: 2024 Mar 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Protein C Inhibitor*/chemistry , Protein C Inhibitor*/metabolism , Heparin*/chemistry , Heparin*/pharmacology , Serine Proteases*/metabolism , Serine Proteases*/chemistry, Humans ; Thrombin/metabolism ; Protein C/metabolism ; Protein C/chemistry ; Factor Xa/metabolism ; Factor Xa/chemistry ; Amino Acid Sequence ; Enzyme Activation/drug effects

المؤلفون: Liu Y; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China., Cai M; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China., Chen Y; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China., Wu G; Department of Hematology, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China., Li S; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China., Chen Z; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang, Guangdong, China.

المصدر: PeerJ [PeerJ] 2024 Apr 24; Vol. 12, pp. e17261. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN: 2167-8359 (Electronic) Linking ISSN: 21678359 NLM ISO Abbreviation: PeerJ Subsets: MEDLINE

مواضيع طبية MeSH: Protein C*/metabolism , Protein C*/genetics , Disease Models, Animal*, Animals ; Mice ; Protein C Deficiency/genetics ; Mutation ; Male ; Female ; Blood Coagulation/genetics ; Heterozygote ; Gene Editing/methods ; CRISPR-Cas Systems/genetics ; Partial Thromboplastin Time

المؤلفون: Xu F; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Zhang K; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Xu Q; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Ye L; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Zeng M; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Jin Y; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Wang M; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China., Yang L; Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China. YLH91@163.com.

المصدر: Annals of hematology [Ann Hematol] 2024 Feb; Vol. 103 (2), pp. 645-652. Date of Electronic Publication: 2023 Nov 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Protein C Deficiency*/genetics , Protein C Deficiency*/diagnosis , Thrombophilia*, Humans ; Protein C/genetics ; Protein C/metabolism ; Mutation ; Mutation, Missense

SCR Disease Name: Thrombophilia, hereditary

المؤلفون: Egami N; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Ishimura M; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Ochiai M; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Research Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan., Ichiyama M; Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Japan., Inoue H; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Suenobu S; Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University Faculty of Medicine, Yufu, Japan., Nishikubo T; Division of Neonatal Intensive Care, Center of Maternal-Fetal Medicine, Nara Medical University, Kashihara, Japan., Nogami K; Department of Pediatrics, Nara Medical University, Kashihara, Japan., Ishiguro A; Center for Postgraduate Education and Training, National Center for Child Health and Development, Setagaya-ku, Japan., Hotta T; Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan., Uchiumi T; Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan., Kang D; Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan., Ohga S; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

المصدر: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Mar; Vol. 71 (3), pp. e30824. Date of Electronic Publication: 2023 Dec 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Protein S Deficiency*/complications , Protein S Deficiency*/diagnosis , Protein S Deficiency*/genetics , Thrombophilia*/complications , Thrombosis*/etiology , Thrombosis*/genetics , Protein C Deficiency*/genetics , Protein C Deficiency*/complications , Antithrombin III Deficiency*, Infant, Newborn ; Female ; Pregnancy ; Humans ; Retrospective Studies ; Prospective Studies ; Japan/epidemiology ; Protein C/genetics ; Anticoagulants ; Antithrombin III ; Antithrombins

المؤلفون: Mori F; Department of Research and Innovation, Kedrion Biopharma, Bolognana, Italy., Angelini C; Department of Research and Innovation, Kedrion Biopharma, Bolognana, Italy., Farina C; Department of Research and Innovation, Kedrion Biopharma, Bolognana, Italy.

المصدر: Vox sanguinis [Vox Sang] 2024 Mar; Vol. 119 (3), pp. 193-202. Date of Electronic Publication: 2023 Nov 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 0413606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0410 (Electronic) Linking ISSN: 00429007 NLM ISO Abbreviation: Vox Sang Subsets: MEDLINE

مواضيع طبية MeSH: Purpura Fulminans*/drug therapy , Purpura Fulminans*/genetics , Protein C Deficiency*/drug therapy, Infant, Newborn ; Humans ; Protein C/analysis ; Protein C/therapeutic use ; Protein S ; Plasma/chemistry

المؤلفون: Rehill AM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland. Electronic address: https://twitter.com/aislingrehill., Leon G; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland., McCluskey S; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland., Schoen I; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Hernandez-Santana Y; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland., Annett S; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Klavina P; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Robson T; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Curtis AM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Renné T; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hussey S; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland; Department of Paediatrics, University College Dublin and Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., O'Donnell JS; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland., Walsh PT; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland., Preston RJS; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland; National Children's Research Centre, Children's Health Ireland Crumlin, Dublin, Ireland. Electronic address: rogerpreston@rcsi.ie.

المصدر: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Feb; Vol. 22 (2), pp. 394-409. Date of Electronic Publication: 2023 Oct 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE

مواضيع طبية MeSH: Protein C*/metabolism , Thrombophilia*/etiology, Animals ; Mice ; Endothelial Protein C Receptor/metabolism ; Myeloid Cells/metabolism ; Inflammation/metabolism ; Glycolysis ; Mice, Inbred C57BL

المؤلفون: Xue M; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia., Jackson CJ; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia., Lin H; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia., Zhao R; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia., Liang HPH; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia., Weiler H; Versiti Blood Research Institute, Milwaukee, WI 53226, USA.; Department of Physiology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA., Griffin JH; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., March L; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Protein C*/metabolism , Dermatitis, Allergic Contact*/drug therapy , Recombinant Proteins*, Animals ; Mice ; Endothelial Protein C Receptor/metabolism ; Receptor, PAR-1/metabolism ; Signal Transduction ; Cytokines/pharmacology

المؤلفون: Erausquin E; Unit of Protein Crystallography and Structural Immunology, Navarrabiomed, 31008, Navarra, Spain.; Public University of Navarra (UPNA), Pamplona, 31008, Navarra, Spain.; Navarra University Hospital, 31008, Navarra, Spain., Rodríguez-Fernández A; Unit of Protein Crystallography and Structural Immunology, Navarrabiomed, 31008, Navarra, Spain.; Public University of Navarra (UPNA), Pamplona, 31008, Navarra, Spain.; Navarra University Hospital, 31008, Navarra, Spain., Rodríguez-Lumbreras LÁ; Instituto de Ciencias de La Vid y del Vino (ICVV), CSIC-UR-Gobierno de La Rioja, 26007, Logroño, Spain., Fernández-Recio J; Instituto de Ciencias de La Vid y del Vino (ICVV), CSIC-UR-Gobierno de La Rioja, 26007, Logroño, Spain., Dichiara-Rodríguez MG; Unit of Protein Crystallography and Structural Immunology, Navarrabiomed, 31008, Navarra, Spain.; Public University of Navarra (UPNA), Pamplona, 31008, Navarra, Spain.; Navarra University Hospital, 31008, Navarra, Spain., López-Sagaseta J; Unit of Protein Crystallography and Structural Immunology, Navarrabiomed, 31008, Navarra, Spain. jacinto.lopez.sagaseta@navarra.es.; Public University of Navarra (UPNA), Pamplona, 31008, Navarra, Spain. jacinto.lopez.sagaseta@navarra.es.; Navarra University Hospital, 31008, Navarra, Spain. jacinto.lopez.sagaseta@navarra.es.

المصدر: Scientific reports [Sci Rep] 2024 Jan 31; Vol. 14 (1), pp. 2591. Date of Electronic Publication: 2024 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Protein C*/metabolism , Receptors, Cell Surface*/metabolism, Animals ; Endothelial Protein C Receptor/metabolism ; Mammals/metabolism