المؤلفون: Dushkin A; Project Office, Moscow City Hospital 52, 123182 Moscow, Russia., Afanasiev M; Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia., Afanasiev S; G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for the Oversight of Consumer Protection and Welfare, 125212 Moscow, Russia., Grishacheva T; Center of Laser Medicine, First Pavlov State Medical University of St. Petersburg, 192071 Saint-Petersburg, Russia., Biryukova E; Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia., Dushkina I; Gynecology Department, Moscow City Hospital 67, 123423 Moscow, Russia., Karaulov A; Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 08; Vol. 25 (17). Date of Electronic Publication: 2024 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Papillomavirus Infections*/virology , Papillomavirus Infections*/genetics , Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/genetics , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics, Humans ; Female ; Adult ; Uterine Cervical Neoplasms/virology ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Middle Aged ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 3/metabolism ; Toll-Like Receptor 8/metabolism ; Toll-Like Receptor 8/genetics ; Prospective Studies ; Severity of Illness Index ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

المؤلفون: Li Y; Institute of Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia., Pacoste LC; Department of Materials and Environmental Chemistry, Stockholm University, Frescativägen 8, 114 18 Stockholm, Sweden., Gu W; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Ve T; Institute for Glycomics, Griffith University, Southport, Queensland 4215, Australia., Kobe B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Xu H; Department of Materials and Environmental Chemistry, Stockholm University, Frescativägen 8, 114 18 Stockholm, Sweden., Nanson JD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

المصدر: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2024 Sep 01; Vol. 80 (Pt 9), pp. 699-712. Date of Electronic Publication: 2024 Sep 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7983 (Electronic) Linking ISSN: 20597983 NLM ISO Abbreviation: Acta Crystallogr D Struct Biol Subsets: MEDLINE

مواضيع طبية MeSH: Toll-Like Receptor 2*/chemistry , Toll-Like Receptor 2*/metabolism , Myeloid Differentiation Factor 88*/chemistry , Myeloid Differentiation Factor 88*/metabolism, Humans ; Protein Domains ; Models, Molecular ; Toll-Like Receptor 6/chemistry ; Toll-Like Receptor 6/metabolism ; Toll-Like Receptor 1/chemistry ; Toll-Like Receptor 1/metabolism ; Crystallography, X-Ray/methods ; Receptors, Interleukin-1/chemistry ; Receptors, Interleukin-1/metabolism ; Protein Multimerization

المؤلفون: Hagström A; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, 171 77 Stockholm, Sweden., Kal Omar R; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, 171 77 Stockholm, Sweden., Witzenhausen H; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, 171 77 Stockholm, Sweden., Lardner E; St. Erik Eye Hospital, 17164 Stockholm, Sweden., Abdiu O; Ögonspecialisterna Farsta, 12347 Stockholm, Sweden., Stålhammar G; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, 171 77 Stockholm, Sweden.; St. Erik Eye Hospital, 17164 Stockholm, Sweden.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 09; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Uveal Neoplasms*/metabolism , Uveal Neoplasms*/genetics , Uveal Neoplasms*/pathology , Uveal Neoplasms*/mortality , Melanoma*/metabolism , Melanoma*/genetics , Melanoma*/pathology , Receptor, Melatonin, MT1*/metabolism , Receptor, Melatonin, MT1*/genetics , Nuclear Receptor Subfamily 1, Group F, Member 1*/metabolism , Nuclear Receptor Subfamily 1, Group F, Member 1*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics, Humans ; Male ; Female ; Middle Aged ; Aged ; Receptor, Melatonin, MT2/metabolism ; Receptor, Melatonin, MT2/genetics ; Gene Expression Regulation, Neoplastic ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Prognosis ; Adult ; Aged, 80 and over ; Mutation ; Melatonin/metabolism ; Kaplan-Meier Estimate

SCR Disease Name: Uveal melanoma

المؤلفون: Verma J; Department of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, New Hampshire, USA., Vashisth H; Department of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, New Hampshire, USA.; Department of Chemistry, University of New Hampshire, Durham, New Hampshire, USA.; Integrated Applied Mathematics Program, University of New Hampshire, Durham, New Hampshire, USA.; Molecular and Cellular Biotechnology Program, University of New Hampshire, Durham, New Hampshire, USA.

المصدر: Proteins [Proteins] 2024 Aug; Vol. 92 (8), pp. 905-922. Date of Electronic Publication: 2024 Mar 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0134 (Electronic) Linking ISSN: 08873585 NLM ISO Abbreviation: Proteins Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation* , Thermodynamics* , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/metabolism , Receptor, IGF Type 1*/chemistry , Receptor, IGF Type 1*/antagonists & inhibitors , Receptor, IGF Type 1*/metabolism , Protein Binding*, Humans ; Allosteric Regulation ; Allosteric Site ; Binding Sites ; Receptor, Insulin/chemistry ; Receptor, Insulin/metabolism ; Receptor, Insulin/antagonists & inhibitors ; Hydrogen Bonding

المؤلفون: Kosar M; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland., Mach L; Medicinal Chemistry, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Berlin, Berlin, Germany., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland., Nazaré M; Medicinal Chemistry, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Berlin, Berlin, Germany., Pacher P; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA., Grether U; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

المصدر: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2024 Aug; Vol. 34 (8), pp. 665-700. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE

مواضيع طبية MeSH: Patents as Topic* , Receptor, Cannabinoid, CB2*/metabolism , Receptor, Cannabinoid, CB2*/agonists , Receptor, Cannabinoid, CB2*/antagonists & inhibitors , Drug Development* , Cannabinoid Receptor Agonists*/pharmacology, Humans ; Animals ; Ligands ; Cannabinoid Receptor Antagonists/pharmacology

المؤلفون: Matboli M; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. DrMarwa_Matboly@med.asu.edu.eg., Hossam N; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Farag D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr International University, Cairo, Egypt., Hassan M; Department of Biology/Zoology, Biotechnology Program, Faculty of Science, Port Said University, Port Said, Egypt.; Zewail City for Science & Technology, Center for Genomics, Helmy Institute for Medical Science, Giza, Egypt., Shehata H; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Aboelhussein M; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ismail N; Department of Pathology, University of Illinois at Chicago, Chicago, IL, 60612, USA., Eissa S; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. drsanaa_mohamed@med.asu.edu.eg.; MASRI Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt. drsanaa_mohamed@med.asu.edu.eg.

المصدر: BMC cancer [BMC Cancer] 2024 Jul 10; Vol. 24 (1), pp. 824. Date of Electronic Publication: 2024 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Tumor Microenvironment*/genetics , Gene Expression Regulation, Neoplastic* , Toll-Like Receptor 8*/genetics , Toll-Like Receptor 8*/metabolism, Humans ; Cell Line, Tumor ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 1/genetics ; Toll-Like Receptor 1/metabolism ; Toll-Like Receptors/metabolism ; Toll-Like Receptors/genetics ; Female ; Male ; Inflammation/genetics ; Inflammation/metabolism ; Signal Transduction

المؤلفون: Andrade AD; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Almeida PGC; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Mariani NAP; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Santos NCM; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Camargo IA; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Martini PV; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Kushima H; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil., Ai D; Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University Giessen, Giessen, Germany., Avellar MCW; Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil., Meinhardt A; Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University Giessen, Giessen, Germany.; Hessian Center of Reproductive Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.; Centre of Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia., Pleuger C; Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University Giessen, Giessen, Germany.; Hessian Center of Reproductive Medicine, Justus-Liebig-University of Giessen, Giessen, Germany., Silva EJR; Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil.

المصدر: Andrology [Andrology] 2024 Jul; Vol. 12 (5), pp. 1024-1037. Date of Electronic Publication: 2024 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE

مواضيع طبية MeSH: Epididymitis*/genetics , Epididymitis*/metabolism , Epididymitis*/microbiology , Signal Transduction* , Lipopolysaccharides* , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Toll-Like Receptor 2*/genetics , Toll-Like Receptor 2*/metabolism , Teichoic Acids*/pharmacology, Animals ; Male ; Mice ; Uropathogenic Escherichia coli ; Escherichia coli Infections/immunology ; Escherichia coli Infections/genetics ; Toll-Like Receptor 6/genetics ; Toll-Like Receptor 6/metabolism ; Epididymis/metabolism ; TNF Receptor-Associated Factor 6/metabolism ; TNF Receptor-Associated Factor 6/genetics ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Mice, Inbred C57BL ; Acute Disease

المؤلفون: Patel AM; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Willingham A; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Cheng AC; Modeling and Informatics, Merck & Co. Inc., South San Francisco, California 94080, United States., Tomazela D; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Bowman E; Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States., Kofman E; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Zhang F; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Bao J; External Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Sanzone JR; External Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Choy JW; Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States., Flygare JA; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Han JH; Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States., Pradhan K; Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States., Kieffer M; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Chernyak N; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Akbari P; Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States., Liu P; External Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Mehmood R; Modeling and Informatics, Merck & Co. Inc., South San Francisco, California 94080, United States., Naravula S; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Hollingsworth SA; Modeling and Informatics, Merck & Co. Inc., South San Francisco, California 94080, United States., Bhagwat B; Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States., Lang SB; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States., Seganish WM; Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15756-15779. Date of Electronic Publication: 2024 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Toll-Like Receptor 7*/agonists , Toll-Like Receptor 8*/agonists , Toll-Like Receptor 8*/metabolism , Immunoconjugates*/pharmacology , Immunoconjugates*/chemistry , Drug Design*, Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/immunology ; Structure-Activity Relationship ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/chemical synthesis ; Cytokines/metabolism ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/antagonists & inhibitors ; Pyrazoles/pharmacology ; Pyrazoles/chemistry

المؤلفون: Bester SM; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Linwood R; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Kataoka R; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Wu WI; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Mou TC; Pfizer Boulder Research and Development, Boulder, CO 80301, USA.

المصدر: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Sep 01; Vol. 80 (Pt 9), pp. 210-219. Date of Electronic Publication: 2024 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-230X (Electronic) Linking ISSN: 2053230X NLM ISO Abbreviation: Acta Crystallogr F Struct Biol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Catalytic Domain*, Humans ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Binding Sites ; Models, Molecular ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Crystallization ; Apoenzymes/chemistry ; Apoenzymes/metabolism ; Apoenzymes/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

المؤلفون: Tang CW; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Yang JH; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Qin JW; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Wu HJ; Department of Digestive Endoscopy Center, Fujian Provincial Hospital, Fuzhou, 350001, Fujian, China., Cui HP; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Ge LY; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China., Liu AQ; Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China. liuaiqun2004@163.com.

المصدر: Digestive diseases and sciences [Dig Dis Sci] 2024 Sep; Vol. 69 (9), pp. 3276-3289. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Exosomes*/metabolism , Exosomes*/genetics , Exosomes*/immunology , Stomach Neoplasms*/immunology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Programmed Cell Death 1 Receptor*/metabolism , Programmed Cell Death 1 Receptor*/genetics , B7-H1 Antigen*/metabolism , B7-H1 Antigen*/genetics, Humans ; Male ; Female ; Middle Aged ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; Natural Cytotoxicity Triggering Receptor 3/genetics ; Natural Cytotoxicity Triggering Receptor 3/metabolism ; Natural Cytotoxicity Triggering Receptor 1/metabolism ; Natural Cytotoxicity Triggering Receptor 1/genetics ; Aged ; Interferon-gamma/metabolism ; Gene Expression Regulation, Neoplastic ; Receptors, IgG/genetics ; Receptors, IgG/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; CD56 Antigen/metabolism ; Case-Control Studies