المؤلفون: Singh R; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India; School of Chemistry, Indian Institutes of Science Education and Research, Thiruvananthapuram, Kerala, 695551, India., Sindhu J; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar, 125004, India., Devi M; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India., Kumar P; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India. Electronic address: parvinchem@kuk.ac.in., Lal S; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India., Kumar A; Department of Pharmaceutical Sciences, GJUS&T, Hisar, -125001, India., Singh D; Department of Chemistry, Maharshi Dayanand University, Rohtak, India, 124001., Kumar H; Department of Chemistry, School of Basic Sciences, Central University Haryana, Mahendergarh, India.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116623. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Molecular Docking Simulation* , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/metabolism , Molecular Dynamics Simulation* , Quantitative Structure-Activity Relationship* , Thiazolidinediones*/chemistry , Thiazolidinediones*/chemical synthesis , Thiazolidinediones*/pharmacology, Molecular Structure ; Dose-Response Relationship, Drug ; Humans

المؤلفون: Xu T; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China., Yang J; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China., Li D; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China., Challa M; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China., Zou C; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China., Deng P; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: 100865@cqmu.ed.cn., Zhang SL; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: zhangsl@cqu.edu.cn., Xu B; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: xubiao@cqmu.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116610. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Isocitrate Dehydrogenase*/antagonists & inhibitors , Isocitrate Dehydrogenase*/genetics , Isocitrate Dehydrogenase*/metabolism , Biological Products*/pharmacology , Biological Products*/chemistry , Biological Products*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Cell Proliferation*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Discovery* , Drug Screening Assays, Antitumor* , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Animals ; Mice ; Molecular Structure ; Mutation ; Cell Line, Tumor ; Drug Evaluation, Preclinical ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/metabolism

المؤلفون: Zhang Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Kang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Zhou Q; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Chen M; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Zhang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Shi Z; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China., Qiao Y; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, 430062, People's Republic of China., Qi C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China; Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, People's Republic of China. Electronic address: qichangxing@hust.edu.cn., Zhang Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China. Electronic address: zhangyh@mails.tjmu.edu.cn.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107575. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Penicillium*/chemistry , Lipopolysaccharides*/pharmacology , Lipopolysaccharides*/antagonists & inhibitors , Dose-Response Relationship, Drug*, Mice ; Animals ; Molecular Structure ; Structure-Activity Relationship ; Microglia/drug effects ; Microglia/metabolism ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Nitric Oxide/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Drug Discovery ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/isolation & purification

SCR Organism: Penicillium citrinum

المؤلفون: Hu Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Zhang Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Guo J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Chen S; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Jin J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Li P; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Pan Y; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Lei S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Li J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Wu S; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Bu B; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China. Electronic address: lei.fu@xjtlu.edu.cn.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107588. Date of Electronic Publication: 2024 Jun 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Cell Proliferation*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Drug Screening Assays, Antitumor* , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Membrane Potential, Mitochondrial*/drug effects , Apoptosis*/drug effects , Dose-Response Relationship, Drug* , Reactive Oxygen Species*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Organophosphorus Compounds/pharmacology ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/chemical synthesis

المؤلفون: Rouzi K; Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco., Altay A; Department of Chemistry, Faculty of Arts and Science, Erzincan Binali Yıldırım University, 24100 Erzincan, Turkey. Electronic address: aaltay2013@gmail.com., Bouatia M; Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco., Yeniçeri E; Department of Chemistry, Institute of Science and Technology, Erzincan Binali Yıldırım University, 24002 Erzincan, Turkey., Islam MS; College of Science, Chemistry Department, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia., Oulmidi A; Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium., El Karbane M; Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco., Karrouchi K; Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco. Electronic address: khalid.karrouchi@um5s.net.ma.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107563. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , Apoptosis*/drug effects , Phosphatidylinositol 3-Kinases*/metabolism , Cell Proliferation*/drug effects , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cell Cycle Checkpoints*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Drug Screening Assays, Antitumor* , Dose-Response Relationship, Drug* , Caspases*/metabolism , Isoniazid*/pharmacology , Isoniazid*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/chemistry ; Phosphoinositide-3 Kinase Inhibitors/chemical synthesis ; Mice ; Animals

المؤلفون: Zhong Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Xu J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China., Ding S; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Cao H; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China., Zhang Y; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China., Hu B; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Han S; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Yang H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China., Li J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China; Stake Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Sun Y; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China; Stake Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107550. Date of Electronic Publication: 2024 Jun 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclin-Dependent Kinase 9*/antagonists & inhibitors , Cyclin-Dependent Kinase 9*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Cell Proliferation*/drug effects , Drug Design* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Apoptosis*/drug effects , Dose-Response Relationship, Drug*, Humans ; Ligands ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Drug Discovery ; Animals ; HCT116 Cells

المؤلفون: Dong Z; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China; Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Pu Q; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Qiu Y; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Zhang R; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Chen Q; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Liu Q; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Khalid A; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Meng F; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Wang G; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China., Liao Z; Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, School of Life Sciences, Southwest University, Chongqing 400715, PR China., Chen M; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China; Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China. Electronic address: mminchen@swu.edu.cn.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107564. Date of Electronic Publication: 2024 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids*/chemistry , Alkaloids*/pharmacology , Alkaloids*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/isolation & purification , Dose-Response Relationship, Drug* , Drug Screening Assays, Antitumor* , Hypericum*/chemistry , Sesquiterpenes*/chemistry , Sesquiterpenes*/pharmacology , Sesquiterpenes*/isolation & purification, Humans ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cycloaddition Reaction ; Molecular Structure ; Stereoisomerism ; Structure-Activity Relationship ; Quinolines/chemistry ; Quinolines/isolation & purification ; Quinolines/pharmacology

المؤلفون: Iqbal Lone W; Natural Products and Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Chand J; Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India., Kumar P; Natural Products and Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Garg Y; Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Ahmed Z; Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mukherjee D; Department of Chemical Sciences, Bose Institute, EN-80, Sector V, Kolkata 700091, WB, India., Goswami A; Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: agoswami@iiim.res.in., Momo H Anãl J; Natural Products and Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: hmunshel.jasha@iiim.res.in.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107581. Date of Electronic Publication: 2024 Jun 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition*/drug effects , Cyclin-Dependent Kinase 2*/metabolism , Cyclin-Dependent Kinase 2*/antagonists & inhibitors , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Screening Assays, Antitumor* , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Dose-Response Relationship, Drug* , Cell Proliferation*/drug effects , Colchicine*/pharmacology , Colchicine*/chemistry , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Cyclin-Dependent Kinase 4*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Drug Discovery ; Female ; Apoptosis/drug effects ; Cycloaddition Reaction ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Cell Line, Tumor ; Cell Movement/drug effects

المؤلفون: Abd El-Mawgoud HK; Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, 11767 Cairo, Egypt. Electronic address: Heba.Kamal@women.asu.edu.eg., AboulMagd AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt. Electronic address: asmaa.aboulmaged@nub.edu.eg., Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street 11562, Cairo, Egypt., Hemdan MM; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt., Hassaballah AI; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt., Farag PS; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107622. Date of Electronic Publication: 2024 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Pyrimidines*/chemistry , Apoptosis*/drug effects , Drug Design* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Autophagy*/drug effects , Drug Screening Assays, Antitumor* , Cell Proliferation*/drug effects , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Cell Line, Tumor

المؤلفون: Benoune RA; Laboratory of Synthesis of Molecules with Biological Interest, Faculty of Exact Sciences, Mentouri - Constantine 1 University, 25000 Constantine, Algeria., Dems MA; Biotechnology Research Center,25000 Constantine, Algeria., Boulcina R; Laboratory of Synthesis of Molecules with Biological Interest, Faculty of Exact Sciences, Mentouri - Constantine 1 University, 25000 Constantine, Algeria; Department of Engineering Process, Faculty of Technology, Mostefa Benboulaïd-Batna 2 University, 5000 Batna, Algeria. Electronic address: r.boulcina@univ-batna2.dz., Bensouici C; Biotechnology Research Center,25000 Constantine, Algeria., Robert A; Reims Champagne-Ardenne University, CNRS UMR 7312, ICMR, URCATech, 51100 Reims, France., Harakat D; Reims Champagne-Ardenne University, CNRS UMR 7312, ICMR, URCATech, 51100 Reims, France., Debache A; Laboratory of Synthesis of Molecules with Biological Interest, Faculty of Exact Sciences, Mentouri - Constantine 1 University, 25000 Constantine, Algeria.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107598. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Butyrylcholinesterase*/metabolism , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/chemistry , Quantitative Structure-Activity Relationship* , Antioxidants*/pharmacology , Antioxidants*/chemical synthesis , Antioxidants*/chemistry , Molecular Docking Simulation*, Molecular Structure ; Humans ; Dose-Response Relationship, Drug ; Acetylcholinesterase/metabolism