المؤلفون: Christopher R Horne, Sarah G. Heath, Christine C. Winterbourn, Alexander V. Peskin, Christoph Göbl, Jennifer M. Crowther, Flavia Carla Meotti, Paul E. Pace, Renwick C. J. Dobson, Kelsey Kean, Albert S. Peixoto, P. Andrew Karplus

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, crystal structure, FF, fully folded, TrxR, thioredoxin reductase, Thioredoxin reductase, CP, peroxidatic cysteine, hydrogen peroxide, Peroxiredoxin 2, CR, resolving cysteine, Crystallography, X-Ray, Biochemistry, redox regulation, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Prdx, peroxiredoxin, Humans, Trx, thioredoxin, Amino Acid Sequence, Cysteine, Molecular Biology, chemistry.chemical_classification, AUC, analytical ultracentrifugation, LU, locally unfolded, 030102 biochemistry & molecular biology, biology, PEROXIDASE, peroxiredoxin, Active site, Peroxiredoxins, SAXS, small angle X-Ray scattering, Cell Biology, Glutathione, Oxidants, resolving Cys mutants, 030104 developmental biology, chemistry, kinetics, Mutation, biology.protein, Biophysics, Thiol, SEC, size exclusion chromatography, Sulfenic acid, Peroxiredoxin, Oxidation-Reduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afc470017a5aa7bd3a20443346a6715
https://doi.org/10.1016/j.jbc.2021.100494

المؤلفون: Peskin AV; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand., Meotti FC; Department of Biochemistry, Chemistry Institute, University of Sao Paulo, Sao Paulo, SP, Brazil., Kean KM; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA., Göbl C; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand., Peixoto AS; Department of Biochemistry, Chemistry Institute, University of Sao Paulo, Sao Paulo, SP, Brazil., Pace PE; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand., Horne CR; School of Biological Sciences, University of Canterbury, Christchurch, New Zealand., Heath SG; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand., Crowther JM; School of Biological Sciences, University of Canterbury, Christchurch, New Zealand., Dobson RCJ; School of Biological Sciences, University of Canterbury, Christchurch, New Zealand., Karplus PA; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA. Electronic address: andy.karplus@oregonstate.edu., Winterbourn CC; Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand. Electronic address: christine.winterbourn@otago.ac.nz.

المصدر: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100494. Date of Electronic Publication: 2021 Mar 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine/*chemistry , Cysteine/*metabolism , Hydrogen Peroxide/*metabolism , Peroxiredoxins/*chemistry , Peroxiredoxins/*metabolism, Amino Acid Sequence ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Hydrogen Peroxide/chemistry ; Mutation ; Oxidants/chemistry ; Oxidants/metabolism ; Oxidation-Reduction ; Structure-Activity Relationship