المؤلفون: Hamed OA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt., Abou-Elmagd El-Sayed N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt., Mahmoud WR; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt., F Elmasry G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt. Electronic address: ghada.elmasry@pharma.cu.edu.eg.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107413. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclin-Dependent Kinase 2*/antagonists & inhibitors , Cyclin-Dependent Kinase 2*/metabolism , Roscovitine*/pharmacology , Roscovitine*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Molecular Docking Simulation* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Pyrimidines*/chemistry , Drug Design* , Drug Screening Assays, Antitumor* , Cell Proliferation*/drug effects , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Purines/pharmacology ; Purines/chemistry ; Purines/chemical synthesis

المؤلفون: Moëlo C; EFS, Université de Bretagne Occidentale, Inserm UMR 1078, GGB, Brest, France., Quillévéré A; EFS, Université de Bretagne Occidentale, Inserm UMR 1078, GGB, Brest, France., Le Roy L; EFS, Université de Bretagne Occidentale, Inserm UMR 1078, GGB, Brest, France., Timsit S; EFS, Université de Bretagne Occidentale, Inserm UMR 1078, GGB, Brest, France.; Neurology and Stroke Unit Department, CHRU de Brest, Inserm1078, Université de Bretagne Occidentale, Brest, France.

المصدر: Glia [Glia] 2024 Feb; Vol. 72 (2), pp. 322-337. Date of Electronic Publication: 2023 Oct 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE

مواضيع طبية MeSH: Brain Edema*/drug therapy , Brain Edema*/etiology , Brain Edema*/metabolism , Ischemic Stroke*/complications , Ischemic Stroke*/metabolism, Humans ; Roscovitine/therapeutic use ; Roscovitine/metabolism ; Aquaporin 4/metabolism ; Astrocytes/metabolism

المؤلفون: Wang F; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China., Xu W; Department of Anesthesiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China., Liu X; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China., Zhang J; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

المصدر: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2024 Jan 25; Vol. 56 (1), pp. 71-81.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN: 1745-7270 (Electronic) Linking ISSN: 16729145 NLM ISO Abbreviation: Acta Biochim Biophys Sin (Shanghai) Subsets: MEDLINE

مواضيع طبية MeSH: Dexmedetomidine*/pharmacology , Epithelial-Mesenchymal Transition*/drug effects , Signal Transduction*, Humans ; Cadherins/metabolism ; Epithelial Cells/metabolism ; Glucose/toxicity ; Glucose/metabolism ; Reactive Oxygen Species/metabolism ; Roscovitine/metabolism ; Roscovitine/pharmacology ; Cyclin-Dependent Kinase 5/drug effects ; Cyclin-Dependent Kinase 5/metabolism ; Dynamins/drug effects ; Dynamins/metabolism

المؤلفون: Praxedes ÉA; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil., Oliveira LRM; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil., da Silva Viana JV; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil., Rodrigues LLV; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil., de Brito Vieira Neto J; Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil., Sales SLA; Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil., Dos Santos Luciano MC; Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil., Oliveira MF; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil., Pessoa C; Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil., Pereira AF; Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil. alexsandra.pereira@ufersa.edu.br.

المصدر: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2024 Mar; Vol. 60 (3), pp. 249-257. Date of Electronic Publication: 2024 Mar 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X (Electronic) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE

مواضيع طبية MeSH: Dasyproctidae*, Animals ; Roscovitine/pharmacology ; Purines/pharmacology ; Cell Cycle ; Fibroblasts ; Cells, Cultured

المؤلفون: Oner M; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, R.O.C., Lin E; Department of Urology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C., Chiu KY; Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan, R.O.C., Chen MC; Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Prince GMSH; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, R.O.C., Lai CH; Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan, R.O.C., Hsieh JT; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A., Wang HY; Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C., Lin HO; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, R.O.C.; hlin@dragon.nchu.edu.tw.

المصدر: Anticancer research [Anticancer Res] 2024 Feb; Vol. 44 (2), pp. 543-553.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Urinary Bladder Neoplasms*/genetics , Urinary Bladder Neoplasms*/pathology, Humans ; Cell Proliferation ; Cyclin-Dependent Kinase 5/genetics ; Cyclin-Dependent Kinase 5/metabolism ; Roscovitine ; Survival Rate

المؤلفون: Meijer L; ManRos Therapeutics, Presqu'île de Perharidy, Roscoff 29680, France. Electronic address: meijer@manros-therapeutics.com., Hery-Arnaud G; Unité de Bactériologie, Hôpital de la Cavale Blanche, CHRU Brest, Brest cedex 29609, France; Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest 29200, France., Leven C; Département de Biochimie et Pharmaco-Toxicologie, CHRU Brest, Brest cedex 29609, France; Univ Brest, EA 3878, GETBO, Brest 29200, France., Nowak E; INSERM CIC 1412, Brest University Hospital, Brest cedex 29609, France., Hillion S; Laboratoire d'Immunologie et Immunothérapie, CHRU de Brest, INSERM U1227, 2 avenue Foch, BP824, 29609 Brest cedex, France., Renaudineau Y; Laboratoire d'Immunologie et Immunothérapie, CHRU de Brest, INSERM U1227, 2 avenue Foch, BP824, 29609 Brest cedex, France., Durieu I; Research on Healthcare Performance (RESHAPE), INSERM U1290, Claude Bernard Lyon 1 University, 8 Avenue Rockefeller, 69003 Lyon, France; Department of Internal Medicine, Cystic Fibrosis Center, Hospices Civils de Lyon, Pierre-Bénite 69495, France., Chiron R; CHU Montpellier, Maladies Respiratoires, Hôpital Arnaud de Villeneuve, 371, avenue du Doyen Gaston Giraud, Montpellier 34295, France., Prevotat A; Service de pneumologie, CHR - Hôpital Calmette, Boulevard du Pr. Leclercq, Lille 59037, France., Fajac I; APHP.Centre - Université de Paris, 27 rue du Faubourg Saint-Jacques, Paris 75014, France., Hubert D; APHP.Centre - Université de Paris, 27 rue du Faubourg Saint-Jacques, Paris 75014, France., Murris-Espin M; CHU Toulouse, CRCM adulte, Service de Pneumologie, Clinique des Voies Respiratoires. Hôpital Larrey, 24 chemin de Pouvourville, Toulouse 31059, France., Huge S; Centre Hospitalier Bretagne Atlantique, CRCM Mixte 56, 20 Boulevard du général Maurice Guillaudot, Vannes cedex 56017, France., Danner-Boucher I; CHU de Nantes, Service de Pneumologie, Hôpital Nord Laennec, Boulevard Jacques-Monod, Nantes 44093, Saint-Herblain, France., Ravoninjatovo B; Centre de Ressources et de Compétences de la Mucoviscidose, Maladies Respiratoires et Allergiques, Hôpital Maison Blanche - CHU Reims, 45 rue Cognacq-Jay, 51100 Reims, France., Leroy S; CHU de Nice, Hôpital Pasteur, Service de Pneumologie, Oncologie Thoracique et Soins Intensifs Respiratoires, 30 Voie Romaine, CS 51069, Nice cedex 1 06001, France., Macey J; CHU Bordeaux, Hôpital Haut-Lévêque, Service de Pneumologie, Avenue de Magellan, Pessac cedex 33604, France., Urban T; Département de Pneumologie, CHU Angers, Site de Larrey, 4 rue de Larrey, Angers cedex 49933, France., Rault G; Fondation Ildys, Centre de Perharidy, Roscoff cedex 29684, France., Mottier D; Département de Biochimie et Pharmaco-Toxicologie, CHRU Brest, Brest cedex 29609, France., Berre RL; Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest 29200, France; Département de Médecine Interne et Pneumologie, CHRU Brest, Brest cedex 29609, France.

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2022 May; Vol. 21 (3), pp. 529-536. Date of Electronic Publication: 2021 Dec 24.

نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis*/diagnosis , Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/metabolism , Cystic Fibrosis*/microbiology , Roscovitine*/therapeutic use, Animals ; Double-Blind Method ; Humans ; Protein Kinase Inhibitors/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/metabolism ; Pseudomonas aeruginosa ; Quality of Life

المؤلفون: Yagcioglu S; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey., Ersoy N; Department of Reproduction and Artificial Insemination, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey., Demir K; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey., Birler S; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey., Pabuccuoglu S; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey.

المصدر: Reproduction in domestic animals = Zuchthygiene [Reprod Domest Anim] 2023 Sep; Vol. 58 (9), pp. 1251-1260. Date of Electronic Publication: 2023 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Paul Parey Scientific Publishers Country of Publication: Germany NLM ID: 9015668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0531 (Electronic) Linking ISSN: 09366768 NLM ISO Abbreviation: Reprod Domest Anim Subsets: MEDLINE

مواضيع طبية MeSH: Purines*/pharmacology , Purines*/metabolism , Sheep, Domestic*, Animals ; Sheep ; Roscovitine/pharmacology ; Roscovitine/metabolism ; Cell Cycle ; Fibroblasts

المؤلفون: Le Roy L; Inserm, Université Brest, EFS, UMR 1078, GGB, F-29200 Brest, France., Letondor A; Inserm, Université Brest, EFS, UMR 1078, GGB, F-29200 Brest, France., Le Roux C; Inserm, Université Brest, EFS, UMR 1078, GGB, F-29200 Brest, France., Amara A; Inserm, Université Brest, EFS, UMR 1078, GGB, F-29200 Brest, France., Timsit S; Inserm, Université Brest, EFS, UMR 1078, GGB, F-29200 Brest, France.; Neurology and Stroke Unit Department, CHRU de Brest, Inserm1078, Université de Bretagne Occidentale, F-29200 Brest, France.

المصدر: Cells [Cells] 2021 Jan 08; Vol. 10 (1). Date of Electronic Publication: 2021 Jan 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*blood supply , Brain/*pathology , Brain Ischemia/*drug therapy , Brain Ischemia/*immunology , Cyclin-Dependent Kinases/*antagonists & inhibitors , Leukocytes/*pathology , Roscovitine/*therapeutic use, Animals ; Cyclin-Dependent Kinases/metabolism ; Humans ; Leukocytes/drug effects ; Models, Biological ; Roscovitine/chemistry ; Roscovitine/pharmacology

المؤلفون: Al-Jassas RM; Department of Chemistry, King Saud University, Riyadh, Saudi Arabia., Islam MS; Department of Chemistry, King Saud University, Riyadh, Saudi Arabia., Al-Majid AM; Department of Chemistry, King Saud University, Riyadh, Saudi Arabia., Nafie MS; Department of Chemistry (Biochemistry program), Faculty of Science, Suez Canal University, Ismailia, Egypt., Haukka M; Department of Chemistry, University of Jyväskylä, Jyväskylä, Finland., Rahman AFMM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Alayyaf AMA; Department of Chemistry, King Saud University, Riyadh, Saudi Arabia., Barakat A; Department of Chemistry, King Saud University, Riyadh, Saudi Arabia.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 Aug; Vol. 356 (8), pp. e2300185. Date of Electronic Publication: 2023 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/chemistry, Humans ; Oxindoles/pharmacology ; Oxindoles/chemistry ; Cell Line, Tumor ; Structure-Activity Relationship ; Roscovitine/pharmacology ; Molecular Docking Simulation ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Apoptosis

المؤلفون: Wani NA; Reproductive Biotechnology Center, Post Box 299003, Dubai, United Arab Emirates. Electronic address: nwani@reprobiotech.ae., Hong SB; Reproductive Biotechnology Center, Post Box 299003, Dubai, United Arab Emirates.

المصدر: Theriogenology [Theriogenology] 2020 Nov; Vol. 157, pp. 176-180. Date of Electronic Publication: 2020 Jul 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

مواضيع طبية MeSH: Camelus* , In Vitro Oocyte Maturation Techniques*/veterinary , Roscovitine*/pharmacology, Animals ; Blastocyst ; Female ; Oocytes