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1دورية أكاديمية
المؤلفون: Torres-Carmona E; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Nakajima S; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Neuropsychiatry, Keio University, Minato, Tokyo, Japan., Iwata Y; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Ueno F; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Stefan C; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Song J; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Abdolizadeh A; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Koizumi MT; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Kambari Y; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Amaev A; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Agarwal SM; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada., Mar W; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., de Luca V; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada., Remington G; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada., Gerretsen P; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada., Graff-Guerrero A; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, ON, Canada. Electronic address: Ariel.Graff@camh.ca.
المصدر: Schizophrenia research [Schizophr Res] 2024 Aug; Vol. 270, pp. 152-161. Date of Electronic Publication: 2024 Jun 22.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
مواضيع طبية MeSH: Clozapine*/pharmacology , Astrocytes*/drug effects , Astrocytes*/metabolism , Astrocytes*/pathology , Antipsychotic Agents*/pharmacology , Proton Magnetic Resonance Spectroscopy* , Schizophrenia, Treatment-Resistant*/drug therapy , Schizophrenia, Treatment-Resistant*/metabolism, Humans ; Adult ; Male ; Female ; Middle Aged ; Inositol/metabolism ; Schizophrenia/drug therapy ; Schizophrenia/metabolism ; Schizophrenia/diagnostic imaging ; Schizophrenia/pathology
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2دورية أكاديمية
المؤلفون: Barruel D; GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, 1, rue Cabanis, 75014 Paris, France. Electronic address: d.barruel@ghu-paris.fr., Hilbey J; Sorbonne Université, Paris, France; Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé, LIMICS, Paris, France., Charlet J; Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé, LIMICS, Paris, France; Assistance Publique-Hôpitaux de Paris, Paris, France., Chaumette B; GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, 1, rue Cabanis, 75014 Paris, France; Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM, U1266 Paris, France; Department of Psychiatry, McGill University, Montréal, QC, Canada., Krebs MO; GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, 1, rue Cabanis, 75014 Paris, France; Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM, U1266 Paris, France., Dauriac-Le Masson V; GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, 1, rue Cabanis, 75014 Paris, France.
المصدر: Schizophrenia research [Schizophr Res] 2024 Aug; Vol. 270, pp. 1-10. Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
مواضيع طبية MeSH: Machine Learning* , Schizophrenia, Treatment-Resistant*/drug therapy , Schizophrenia, Treatment-Resistant*/physiopathology, Humans ; Male ; Female ; Adult ; Retrospective Studies ; Antipsychotic Agents/pharmacology ; Risk Factors ; Young Adult ; Middle Aged ; Medication Adherence ; Adolescent ; Prognosis ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology
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3دورية أكاديمية
المؤلفون: Torres-Carmona E; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Ueno F; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Iwata Y; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Neuropsychiatry, Keio University, Minato, Tokyo, Japan., Nakajima S; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Neuropsychiatry, Keio University, Minato, Tokyo, Japan., Song J; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Mar W; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Abdolizadeh A; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Agarwal SM; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Institute Research Program, CAMH, Toronto, ON, Canada., de Luca V; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Institute Research Program, CAMH, Toronto, ON, Canada., Remington G; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Institute Research Program, CAMH, Toronto, ON, Canada., Gerretsen P; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Institute Research Program, CAMH, Toronto, ON, Canada., Graff-Guerrero A; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Institute Research Program, CAMH, Toronto, ON, Canada. Electronic address: Ariel.Graff@camh.ca.
المصدر: Schizophrenia research [Schizophr Res] 2024 Jul; Vol. 269, pp. 103-113. Date of Electronic Publication: 2024 May 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
مواضيع طبية MeSH: Magnetic Resonance Imaging* , Antipsychotic Agents*/pharmacology , Clozapine*/pharmacology , Cerebral Cortex*/diagnostic imaging , Cerebral Cortex*/pathology , Cerebral Cortex*/drug effects , Cerebral Cortex*/physiopathology , Schizophrenia, Treatment-Resistant*/drug therapy , Schizophrenia, Treatment-Resistant*/pathology , Schizophrenia, Treatment-Resistant*/physiopathology , Schizophrenia, Treatment-Resistant*/diagnostic imaging, Humans ; Female ; Male ; Adult ; Middle Aged ; Young Adult ; Schizophrenia/drug therapy ; Schizophrenia/diagnostic imaging ; Schizophrenia/physiopathology ; Schizophrenia/pathology
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4دورية أكاديمية
المؤلفون: Gillespie AL; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK. amy.gillespie@psych.ox.ac.uk.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. amy.gillespie@psych.ox.ac.uk., Walker EM; Department of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, UK., Hannon E; Department of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, UK., McQueen GA; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Sendt KV; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Avila A; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Lally J; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Okhuijsen-Pfeifer C; Department of Psychiatry, University Medical Center, University Utrecht, Utrecht, The Netherlands., van der Horst M; Department of Psychiatry, University Medical Center, University Utrecht, Utrecht, The Netherlands.; GGNet Mental Health, Warnsveld, The Netherlands., Hasan A; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Augsburg, Augsburg, Germany.; DZPG (German Center for Mental Health), partner site München/Augsburg, Augsburg, Germany., Dempster EL; Department of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, UK., Burrage J; Department of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, UK., Bogers J; Mental health Organization Rivierduinen, Leiden, The Netherlands., Cohen D; Department of Community Mental Health Care, MHO North-Holland North, Heerhugowaard, The Netherlands., Boks MP; Department of Psychiatry, University Medical Center, University Utrecht, Utrecht, The Netherlands.; Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.; Dimence Institute for Specialized Mental Health Care, Dimence Group, Deventer, The Netherlands., Collier DA; SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Egerton A; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Luykx JJ; Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands.; Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress & Sleep program) and Amsterdam Public Health (Mental Health program) research institutes, Amsterdam, The Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands., Mill J; Department of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Barrack Road, Exeter, UK., MacCabe JH; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
المصدر: Translational psychiatry [Transl Psychiatry] 2024 Sep 27; Vol. 14 (1), pp. 390. Date of Electronic Publication: 2024 Sep 27.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
مواضيع طبية MeSH: Clozapine*/therapeutic use , DNA Methylation*/drug effects , Antipsychotic Agents*/therapeutic use , Schizophrenia, Treatment-Resistant*/genetics , Schizophrenia, Treatment-Resistant*/drug therapy, Humans ; Male ; Adult ; Female ; Middle Aged ; Epigenesis, Genetic ; Longitudinal Studies ; Cohort Studies ; Schizophrenia/drug therapy ; Schizophrenia/genetics
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5دورية أكاديمية
المؤلفون: Schütz A; Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Munich, Germany., Salahuddin NH; Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Munich, Germany., Priller J; Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Munich, Germany; German Center for Mental Health (DZPG), Germany; Neuropsychiatry, Charité - Universitätsmedizin Berlin and DZNE Berlin, Charitéplatz 1, 10117 Berlin, Germany; University of Edinburgh and UK DRI, 49 Little France Cres, Edinburgh EH16 4SB, UK., Bighelli I; Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Munich, Germany; German Center for Mental Health (DZPG), Germany., Leucht S; Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Munich, Germany; German Center for Mental Health (DZPG), Germany. Electronic address: Stefan.leucht@tum.de.
المصدر: Psychiatry research [Psychiatry Res] 2024 Sep; Vol. 339, pp. 116069. Date of Electronic Publication: 2024 Jul 06.
نوع المنشور: Systematic Review; Journal Article; Meta-Analysis; Review
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE
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6دورية أكاديمية
المؤلفون: Fellowes S; Department of Politics, Philosophy and Religion, County South, Lancaster University, Lancaster, LA1 4YL, UK. m.fellowes1@lancaster.ac.uk.
المصدر: History and philosophy of the life sciences [Hist Philos Life Sci] 2024 Aug 12; Vol. 46 (3), pp. 29. Date of Electronic Publication: 2024 Aug 12.
نوع المنشور: Journal Article; Historical Article
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 8003052 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-6316 (Electronic) Linking ISSN: 03919714 NLM ISO Abbreviation: Hist Philos Life Sci Subsets: MEDLINE
مواضيع طبية MeSH: Schizophrenia, Childhood*/history, History, 20th Century ; Humans ; Autistic Disorder/history ; Autistic Disorder/etiology ; Child ; United States ; Schizophrenia/history ; Schizophrenia/etiology
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7Editorial & Opinion
المؤلفون: Markota M; Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: markota.matej@mayo.edu., Croarkin PE; Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Gentry MT; Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Leung JG; Department of Pharmacy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
المصدر: Schizophrenia research [Schizophr Res] 2024 Jul; Vol. 269, pp. 130-131. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Letter
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
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8دورية أكاديمية
المؤلفون: Martini F; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Spangaro M; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy. spangaro.marco@hsr.it., Bechi M; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Agostoni G; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Buonocore M; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sapienza J; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy., Nocera D; Vita-Salute San Raffaele University, Milan, Italy., Ave C; Vita-Salute San Raffaele University, Milan, Italy., Cocchi F; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cavallaro R; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Bosia M; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
المصدر: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2024 Sep; Vol. 274 (6), pp. 1473-1481. Date of Electronic Publication: 2023 Dec 19.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9103030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8491 (Electronic) Linking ISSN: 09401334 NLM ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Subsets: MEDLINE
مواضيع طبية MeSH: Cognitive Remediation* , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/therapy , Cognitive Dysfunction*/rehabilitation , Cognitive Dysfunction*/physiopathology , Schizophrenia, Treatment-Resistant*/therapy, Humans ; Male ; Female ; Adult ; Middle Aged ; Outcome Assessment, Health Care ; Executive Function/physiology ; Antipsychotic Agents ; Neuropsychological Tests ; Schizophrenia/therapy ; Schizophrenia/physiopathology ; Schizophrenia/complications
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9دورية أكاديمية
المؤلفون: Lui SSY; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China. Electronic address: lsy570@hku.hk., Lam EHY; Castle Peak Hospital, Hong Kong., Wang LL; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; School of Psychology, Shanghai Normal University, Shanghai, China., Leung PBM; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China., Cheung ESL; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China., Wong CHY; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China., Zhan N; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China., Wong RWK; Department of Psychiatry, School of Clinical Medicine, The Unversity of Hong Kong, Hong Kong SAR, China., Siu BWM; Castle Peak Hospital, Hong Kong., Tang DYY; Castle Peak Hospital, Hong Kong., Liu ACY; Castle Peak Hospital, Hong Kong., Chan RCK; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.
المصدر: Schizophrenia research [Schizophr Res] 2024 Aug; Vol. 270, pp. 459-464. Date of Electronic Publication: 2024 Jul 13.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
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10دورية أكاديمية
المؤلفون: Mishra A; Department of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar 751019, India., Maiti R; Department of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar 751019, India., Ramasubbu MK; Department of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar 751019, India., Srinivasan A; Department of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar 751019, India. Electronic address: anandsrinivasan@aiimsbhubaneswar.edu.in.
المصدر: Psychiatry research [Psychiatry Res] 2024 Aug; Vol. 338, pp. 115989. Date of Electronic Publication: 2024 Jun 01.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE
مواضيع طبية MeSH: Clozapine*/pharmacology , Clozapine*/therapeutic use , Antipsychotic Agents*/pharmacology , Drug Therapy, Combination* , Schizophrenia, Treatment-Resistant*/drug therapy, Humans ; Adult ; Male ; Female ; Computer Simulation ; Drug Interactions ; Drug Synergism ; Middle Aged ; Schizophrenia/drug therapy ; Risperidone/pharmacology ; Risperidone/therapeutic use ; Piperazines ; Thiazoles