-
1دورية أكاديمية
المصدر: Molecular Therapy. 26(5)
مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Gene Therapy, Animals, Base Sequence, Binding Sites, Cell Line, Cell Line, Tumor, Clustered Regularly Interspaced Short Palindromic Repeats, Endonucleases, Gene Editing, Gene Targeting, Genetic Variation, Humans, Mammals, Molecular Conformation, Protein Binding, RNA, Guide, Kinetoplastida, CRISPR, Cpf1, RNA uptake, gene editing, gene targeting, scrRNA, synthetic CRISPR RNA, Technology, Medical and Health Sciences, Biotechnology, Clinical sciences, Medical biotechnology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/9443878r
-
2دورية أكاديمية
المؤلفون: Rahdar, Meghdad, McMahon, Moira A, Prakash, Thazha P, Swayze, Eric E, Bennett, C Frank, Cleveland, Don W
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 112(51)
مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Human Genome, Neurosciences, Base Sequence, Clustered Regularly Interspaced Short Palindromic Repeats, Genes, Synthetic, Genetic Engineering, Genome, Human, HEK293 Cells, Humans, Models, Genetic, Molecular Sequence Data, Nucleic Acid Conformation, RNA, RNA Editing, RNA, Guide, Kinetoplastida, genome editing, CRISPR/Cas9, synthetic crRNA, scrRNA
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/67b6k8q1
-
3
المؤلفون: Aldons J. Lusis, Raquel Floyd, Simon Sabir, Miklós Péterfy, Paola León-Mimila, Anthony E. Jones, Linsey Stiles, Dulshan W. Jayasekera, Samuel Canizales-Quinteros, Adriana Huertas-Vazquez, Varun Shravah, Angel A. Cortez, Karthickeyan Chella Krishnan, Ajit S. Divakaruni
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 2مصطلحات موضوعية: 0301 basic medicine, HMDP, Hybrid Mouse Diversity Panel, Male, OXPHOS, oxidative phosphorylation, Mitochondrion, HF/HS diet, diet rich in fat and sucrose, CDAHFD, choline-deficient, L-amino acid-defined, high-fat diet with 0.1% methionine, Oral and gastrointestinal, Hepatitis, LPK, liver pyruvate kinase, Mice, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, Fibrosis, Loss of Function Mutation, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, 2.1 Biological and endogenous factors, Aetiology, scrRNA, scrambled RNA, Original Research, CE, cholesteryl ester, TG, triglyceride, Liver Disease, NAS, NAFLD Activity Score, Gastroenterology, Middle Aged, Up-Regulation, Liver, Gain of Function Mutation, Lipogenesis, Mitochondrial Dysfunction, shRNA, short hairpin RNA, Liver Fibrosis, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, Female, NASH, nonalcoholic steatohepatitis, ITT, insulin tolerance tests, L/PTT, lactate/pyruvate tolerance tests, Adult, medicine.medical_specialty, DEGs, differentially expressed genes, Chronic Liver Disease and Cirrhosis, ETC, electron transport chain, HDL, high-density lipoprotein, Pyruvate Kinase, DNL, de novo lipogenesis, SEM, standard error of the mean, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, Sex Factors, Liver Pyruvate Kinase, Internal medicine, NAFLD, AAV8, adeno-associated virus serotype 8, FFA, free fatty acid, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Obesity, Gene Silencing, Sex Differences, Metabolic and endocrine, TBG, thyroxine binding globulin, Nutrition, Hepatology, Animal, business.industry, Gene Expression Profiling, medicine.disease, TC, total cholesterol, Disease Models, Animal, 030104 developmental biology, Endocrinology, siRNA, small interfering RNA, Disease Models, NAFLD, nonalcoholic fatty liver disease, Steatosis, Digestive Diseases, business, Dyslipidemia, Pyruvate kinase, GTT, glucose tolerance tests
وصف الملف: application/pdf
-
4
المؤلفون: Loss, Omar, Stephenson, F. Anne
المصدر: Molecular and Cellular Neurosciences
مصطلحات موضوعية: DIV, days in vitro, Trafficking kinesin binding protein, PBS, phosphate-buffered saline, Synaptophysin, TRAK, Nerve Tissue Proteins, tau Proteins, MAP, microtubule-associated protein 2, N-Acetylglucosaminyltransferases, Transfection, Axonal Transport, Hippocampus, Article, Cellular and Molecular Neuroscience, Animals, Humans, RNA, Small Interfering, Molecular Biology, PSD-95, postsynaptic density protein 95, scrRNA, scrambled RNA, Cells, Cultured, Mitochondrial transport, Cerebral Cortex, Neurons, Microscopy, Confocal, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Kinesin, Dendrites, Cell Biology, EGFP, enhanced green fluorescent protein, Mitochondria, Rats, Adaptor Proteins, Vesicular Transport, nervous system, shRNA, short hairpin RNA, FITC, fluorescein isothiocyanate, Carrier Proteins, DsRed, discosoma red fluorescent protein, Disks Large Homolog 4 Protein, DAPI, 4′,6-diamidino-2-phenylindole
-
5
المصدر: Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 5
مصطلحات موضوعية: 0301 basic medicine, Technology, Molecular Conformation, Genome, Medical and Health Sciences, gene targeting, scrRNA, chemistry.chemical_compound, Genome editing, Drug Discovery, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Kinetoplastida, Mammals, Gene Editing, Tumor, biology, Chemistry, Gene targeting, Gene Therapy, Biological Sciences, RNA uptake, Gene Targeting, Molecular Medicine, Original Article, RNA, Guide, Kinetoplastida, Protein Binding, Biotechnology, Exonuclease, Computational biology, Cell Line, 03 medical and health sciences, Cpf1, Cell Line, Tumor, Genetics, Animals, Humans, Molecular Biology, Pharmacology, Trans-activating crRNA, Binding Sites, Base Sequence, RNA, Genetic Variation, synthetic CRISPR RNA, Endonucleases, 030104 developmental biology, biology.protein, DNA, Guide
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0bb057ac07277c4df4a6e21c79a34c
https://escholarship.org/uc/item/9443878r -
6
المؤلفون: C. Frank Bennett, Meghdad Rahdar, Don W. Cleveland, Thazha P. Prakash, Moira A. McMahon, Eric E. Swayze
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 51
مصطلحات موضوعية: Molecular Sequence Data, Biology, scrRNA, Genome editing, Genetic, Models, Genetics, CRISPR, Humans, genome editing, Clustered Regularly Interspaced Short Palindromic Repeats, Guide RNA, Kinetoplastida, CRISPR/Cas9, synthetic crRNA, Trans-activating crRNA, CRISPR interference, Multidisciplinary, Genome, Base Sequence, Genome, Human, Cas9, Synthetic, Human Genome, Neurosciences, RNA, HEK293 Cells, PNAS Plus, Genes, RNA editing, Nucleic Acid Conformation, RNA Editing, Genetic Engineering, Guide, Human
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b1cce6f93cb39884afde5e96ed9156
https://escholarship.org/uc/item/67b6k8q1
Full Text via ClinicalKey