المؤلفون: Lassen E; Cryos International Sperm and Egg Bank, Aarhus, Denmark., Pacey A; School of Medical Sciences, Faculty of Biology, Medicine and Health, Core Technology Facility, University of Manchester, Manchester, UK., Skytte AB; Cryos International Sperm and Egg Bank, Aarhus, Denmark., Montgomerie R; Department of Biology, Queen's University, Kingston, ON, Canada.

المصدر: Human reproduction (Oxford, England) [Hum Reprod] 2024 Aug 01; Vol. 39 (8), pp. 1618-1627.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE

مواضيع طبية MeSH: Sperm Motility* , Semen Analysis* , Tissue Donors* , Sperm Banks*, Humans ; Male ; Denmark ; Adult ; Middle Aged ; Sperm Count ; Young Adult ; Adolescent ; Spermatozoa/physiology

المؤلفون: Karaahmet AY; Faculty of Health Sciences, Midwifery Department, Halic University, Istanbul, Türkiye. aysuyildiz@halic.edu.tr., Gençtürk N; Faculty of Health Sciences, Department of Midwifery, Istanbul University-Cerrahpaşa, Istanbul, Türkiye., Kınık E; Graduate Education Institute, Department of Midwifery, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

المصدر: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Aug; Vol. 31 (8), pp. 2481-2492. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Systematic Review; Journal Article; Meta-Analysis

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101291249 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-7205 (Electronic) Linking ISSN: 19337191 NLM ISO Abbreviation: Reprod Sci Subsets: MEDLINE

مواضيع طبية MeSH: Infertility, Male* , Plant Gums*/therapeutic use , Randomized Controlled Trials as Topic* , Sperm Motility*/drug effects , Spermatozoa*/drug effects , Galactans*/therapeutic use , Galactans*/pharmacology, Humans ; Male ; Mannans/pharmacology ; Mannans/therapeutic use ; Fabaceae ; Semen Analysis ; Dietary Supplements ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Sperm Count

المؤلفون: Goss DM; School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia.; NeoGenix Biosciences Pty Ltd, Sydney, New South Wales, Australia.; IVFAustralia, Sydney, New South Wales, Australia., Vasilescu SA; School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia.; NeoGenix Biosciences Pty Ltd, Sydney, New South Wales, Australia., Vasilescu PA; NeoGenix Biosciences Pty Ltd, Sydney, New South Wales, Australia., Cooke S; IVFAustralia, Sydney, New South Wales, Australia., Kim SH; IVFAustralia, Sydney, New South Wales, Australia.; University of New South Wales, Sydney, New South Wales, Australia., Sacks GP; School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia.; IVFAustralia, Sydney, New South Wales, Australia.; University of New South Wales, Sydney, New South Wales, Australia., Gardner DK; NeoGenix Biosciences Pty Ltd, Sydney, New South Wales, Australia.; Melbourne IVF, Melbourne, Victoria, Australia., Warkiani ME; School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia.; NeoGenix Biosciences Pty Ltd, Sydney, New South Wales, Australia.; Institute for Biomedical Materials & Devices (IBMD), University of Technology Sydney, Sydney, New South Wales, Australia.. Electronic address: majid.warkiani@uts.edu.au.

المصدر: Reproductive biomedicine online [Reprod Biomed Online] 2024 Jul; Vol. 49 (1), pp. 103910. Date of Electronic Publication: 2024 Feb 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE

مواضيع طبية MeSH: Azoospermia*/diagnosis , Azoospermia*/therapy , Sperm Injections, Intracytoplasmic*/methods , Artificial Intelligence* , Spermatozoa*, Humans ; Male ; Neural Networks, Computer ; Proof of Concept Study ; Sperm Retrieval ; Adult

المؤلفون: Jiao ZY; Department of Urology, Peking University Third Hospital, Beijing, China.; Peking University Health Science Center, Beijing, China., Li MR; Department of Urology, Peking University Third Hospital, Beijing, China.; Peking University Health Science Center, Beijing, China., Zhuo L; Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China., Fang YY; Department of Urology, Peking University Third Hospital, Beijing, China., Pan JY; Department of Urology, Peking University Third Hospital, Beijing, China., Hong K; Department of Urology, Peking University Third Hospital, Beijing, China.; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.

المصدر: BJU international [BJU Int] 2024 Jul; Vol. 134 (1), pp. 6-12. Date of Electronic Publication: 2023 Dec 26.

نوع المنشور: Journal Article; Systematic Review; Review

بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 100886721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-410X (Electronic) Linking ISSN: 14644096 NLM ISO Abbreviation: BJU Int Subsets: MEDLINE

مواضيع طبية MeSH: Azoospermia*/genetics , Sperm Retrieval*, Humans ; Male ; Pregnancy ; Female ; Sperm Injections, Intracytoplasmic ; Pregnancy Rate ; Chromosome Deletion

المؤلفون: Darmishonnejad Z; Department of Biology, Kish International Campus, University of Tehran, Tehran, Iran.; Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran., Zadeh VH; Department of Cell and Molecular Biology, Faculty of Biology, College of Science, University of Tehran, Tehran, Iran. vhassanzadeh@ut.ac.ir., Tavalaee M; Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran., Kobarfard F; Department of Medical Chemistry, Shahid Beheshti School of Pharmacy, Tehran, Iran., Hassani M; Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran., Gharagozloo P; CellOxess LLC, 15 Roszel Road, Princeton, NJ, 08540, USA., Drevet JR; GReD Institute, Faculté de Médecine, CRBC, Université Clermont Auvergne, 63000, Clermont-Ferrand, France., Nasr-Esfahani MH; Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. mh.nasr-esfahani@royaninstitute.org.

المصدر: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Jul; Vol. 31 (7), pp. 2114-2122. Date of Electronic Publication: 2024 Mar 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101291249 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-7205 (Electronic) Linking ISSN: 19337191 NLM ISO Abbreviation: Reprod Sci Subsets: MEDLINE

مواضيع طبية MeSH: Glycation End Products, Advanced*/metabolism , Mice, Inbred C57BL* , Spermatozoa*/metabolism , Receptor for Advanced Glycation End Products*/metabolism , Sperm Motility*, Animals ; Male ; Mice ; Sperm Count ; Testis/metabolism ; Blood Glucose/metabolism ; Lysine/analogs & derivatives ; Lysine/metabolism ; Oxidative Stress ; DNA Fragmentation

المؤلفون: Zhang XJ; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Hou XN; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Zhou JT; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Shi BL; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Ye JW; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Yang ML; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Jiang XH; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Xu B; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China., Wu LM; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China. E-mail: wlm@ustc.edu.cn., Shi QH; Division of Reproduction and Genetics, First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, Institute of Health and Medicine, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, Anhui 230001, China. E-mail: qshi@ustc.edu.cn.

المصدر: Zoological research [Zool Res] 2024 Sep 18; Vol. 45 (5), pp. 1061-1072.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Science Press Country of Publication: China NLM ID: 101697192 Publication Model: Print Cited Medium: Internet ISSN: 2095-8137 (Print) Linking ISSN: 20958137 NLM ISO Abbreviation: Zool Res Subsets: MEDLINE

مواضيع طبية MeSH: Mice, Knockout* , Sperm Tail*/metabolism , Sperm Tail*/physiology , Microtubule Proteins*/genetics , Microtubule Proteins*/metabolism, Animals ; Male ; Mice ; Fertility/physiology ; Flagella/metabolism ; Flagella/physiology ; Sperm Motility ; Spermatozoa/physiology

المؤلفون: Fuentes F; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Doctoral Program in Applied Cellular and Molecular Biology, Universidad de La Frontera, Temuco, Chile., Contreras MJ; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile., Arroyo-Salvo C; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile., Cabrera P P; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile., Silva M; Department of Veterinary Sciences and Public Health, Universidad Catolica de Temuco, Temuco, Chile., Merino O; Department of Basic Sciences, Faculty of Medicine. Universidad de La Frontera, Temuco, Chile., Arias ME; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Department of Agricultural Production, Faculty of Agriculture and Environmental Sciences, Universidad de La Frontera, Temuco, Chile., Felmer R; Laboratory of Reproduction, Center of Reproductive Biotechnology (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Department of Agricultural Sciences and Natural Resources, Faculty of Agriculture and Environmental Sciences, Universidad de La Frontera, Temuco, Chile. Electronic address: ricardo.felmer@ufrontera.cl.

المصدر: Theriogenology [Theriogenology] 2024 Sep 15; Vol. 226, pp. 29-38. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

مواضيع طبية MeSH: Sperm Capacitation*/drug effects , Spermatozoa*/drug effects , Spermatozoa*/physiology, Animals ; Male ; Horses/physiology ; Calcium/metabolism ; Zona Pellucida/drug effects ; Sperm Motility/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Phosphorylation

المؤلفون: Wang X; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Feng YQ; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Li H; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Xu Y; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Yu J; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Zhou M; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Qiu F; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China., Li N; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China. Electronic address: 202390900042@sdu.edu.cn., Wang Z; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, PR China. Electronic address: zhengpin.wang@sdu.edu.cn.

المصدر: Reproductive biology [Reprod Biol] 2024 Sep; Vol. 24 (3), pp. 100914. Date of Electronic Publication: 2024 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Urban & Partner Country of Publication: Poland NLM ID: 101160559 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2300-732X (Electronic) Linking ISSN: 1642431X NLM ISO Abbreviation: Reprod Biol Subsets: MEDLINE

مواضيع طبية MeSH: Epididymis*/metabolism , Fertility* , Sperm Maturation* , Exoribonucleases*/metabolism, Animals ; Male ; Mice ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosome Multienzyme Ribonuclease Complex/genetics ; Mice, Knockout ; Sperm Motility ; Spermatogenesis ; Spermatozoa/physiology

المؤلفون: Hwang JM; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Lee WJ; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Jo JH; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Uwamahoro C; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Jang SI; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Jung EJ; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Bae JW; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea., Kim DH; Department of Animal Science, Chonnam National University, Gwangju 61186, Republic of Korea., Yi JK; School of Animal Life Convergence Science, Hankyong National University, Anseong 17579, Republic of Korea., Ha JJ; Gyeongbuk Livestock Research Institute, Yeongju 36052, Republic of Korea., Oh DY; Gyeongbuk Livestock Research Institute, Yeongju 36052, Republic of Korea., Kwon WS; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Republic of Korea; Research Institute for Innovative Animal Science, Kyungpook National University, Sangju 37224, Republic of Korea. Electronic address: wskwon@knu.ac.kr.

المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Sep; Vol. 128, pp. 108659. Date of Electronic Publication: 2024 Jul 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Diterpenes, Kaurane*/adverse effects , Signal Transduction*/drug effects , Sperm Motility*/drug effects , Spermatozoa*/drug effects, Animals ; Male ; Adenosine Triphosphate/metabolism ; Cell Survival/drug effects ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Sperm Capacitation/drug effects ; Swine

المؤلفون: Yeste M; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, ES-08010, Spain., Ahmad A; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain., Viñolas E; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain., Recuero S; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain., Bonet S; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain., Pinart E; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, ES-17003, Spain. elisabeth.pinart@udg.edu.; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, ES-17003, Spain. elisabeth.pinart@udg.edu.

المصدر: Biological research [Biol Res] 2024 Aug 23; Vol. 57 (1), pp. 57. Date of Electronic Publication: 2024 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Biomed Central, Ltd Country of Publication: England NLM ID: 9308271 Publication Model: Electronic Cited Medium: Internet ISSN: 0717-6287 (Electronic) Linking ISSN: 07169760 NLM ISO Abbreviation: Biol Res Subsets: MEDLINE

مواضيع طبية MeSH: Sperm Capacitation*/drug effects , Sodium-Calcium Exchanger*/metabolism , Sodium-Calcium Exchanger*/drug effects , Calcium*/metabolism, Animals ; Male ; Swine ; Spermatozoa/drug effects ; Reactive Oxygen Species/metabolism ; Sperm Motility/drug effects ; Acrosome Reaction/drug effects ; Membrane Potential, Mitochondrial/drug effects