المؤلفون: Gupta S; Department of Chemical Engineering, DBT Centre of Excellence for Biopharmaceutical Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India., Dubey A; Department of Chemical Engineering, DBT Centre of Excellence for Biopharmaceutical Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India., Rathore AS; Department of Chemical Engineering, DBT Centre of Excellence for Biopharmaceutical Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. asrathore@biotechcmz.com.

المصدر: Pharmaceutical research [Pharm Res] 2024 Jul; Vol. 41 (7), pp. 1443-1454. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/chemistry , Protein Stability*, Hydrogen-Ion Concentration ; Drug Stability ; Protein Conformation ; Protein Aggregates ; Chromatography, Ion Exchange/methods ; Hydrophobic and Hydrophilic Interactions ; Chromatography, Gel ; Colloids/chemistry ; Biological Products/chemistry ; Humans ; Buffers

المؤلفون: Lebar B; University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical Chemistry, SI-1000 Ljubljana Slovenia.; Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d. SI-1000 Ljubljana, Slovenia., Zidar M; Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d. SI-1000 Ljubljana, Slovenia., Mravljak J; University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical Chemistry, SI-1000 Ljubljana Slovenia., Šink R; Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d. SI-1000 Ljubljana, Slovenia., Žula A; Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d. SI-1000 Ljubljana, Slovenia., Pajk S; University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical Chemistry, SI-1000 Ljubljana Slovenia.

المصدر: Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2024 Sep 14; Vol. 74 (3), pp. 479-493. Date of Electronic Publication: 2024 Sep 14 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sciendo Country of Publication: Poland NLM ID: 9303678 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1846-9558 (Electronic) Linking ISSN: 13300075 NLM ISO Abbreviation: Acta Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Protein Stability* , Antibodies, Monoclonal*/chemistry , Excipients*/chemistry, Buffers ; Osmolar Concentration ; Drug Compounding/methods ; Temperature ; Drug Stability ; Histidine/chemistry ; Freezing ; Chemistry, Pharmaceutical/methods ; Arginine/chemistry ; Protein Aggregates

المؤلفون: Higdon JR; Department of Biology, Valdosta State University, 1500 N Patterson St., Valdosta, GA 31698, USA., Kang J; Department of Biology, Valdosta State University, 1500 N Patterson St., Valdosta, GA 31698, USA. Electronic address: jkang@valdosta.edu.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Aug; Vol. 113 (8), pp. 2656-2657. Date of Electronic Publication: 2024 Mar 28.

نوع المنشور: Letter

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Thermodynamics* , Antibodies, Monoclonal*/chemistry , Drug Stability*, Injections, Subcutaneous ; Humans ; Protein Stability

المؤلفون: Jun T; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA., Shin SH; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA., Won YY; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA; Purdue University Institute for Cancer Research, West Lafayette, IN 47907, USA. Electronic address: yywon@purdue.edu.

المصدر: International journal of pharmaceutics [Int J Pharm] 2024 Oct 25; Vol. 664, pp. 124636. Date of Electronic Publication: 2024 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Polyethylene Glycols*/chemistry , Excipients*/chemistry , Acrylic Resins*/chemistry , Protein Stability*, Drug Stability ; Biological Products/chemistry ; Immunoglobulin G/chemistry ; Polysorbates/chemistry ; Protein Aggregates

المؤلفون: Sankaran PK; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK. Electronic address: Praveen.kallamvalliillamsankaran@astrazeneca.com., Poskute R; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Dewis L; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Watanabe Y; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Wong V; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Fernandez LP; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Shannon R; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Wong L; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Shrubsall R; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Carman L; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Holt A; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Lepore G; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Mishra R; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Sewell L; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Gothard M; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Cheeks M; Cell Culture & Fermentation Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK., Lindo V; Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Cambridge, UK. Electronic address: viv.lindo@astrazeneca.com.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Aug; Vol. 113 (8), pp. 2101-2113. Date of Electronic Publication: 2024 May 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin G*/chemistry , Antibodies, Bispecific*/chemistry , Drug Stability* , Protein Stability*, Protein Processing, Post-Translational ; Hydrogen-Ion Concentration ; Humans ; Antibodies, Monoclonal/chemistry ; Glycosylation ; Oxidative Stress/drug effects

المؤلفون: Rembert KB; Biologics Drug Product Development & Manufacturing, Global CMC, Sanofi, One Mountain Road, Framingham, MA 01701, USA., Gokarn YR; Biologics Drug Product Development & Manufacturing, Global CMC, Sanofi, One Mountain Road, Framingham, MA 01701, USA., Saluja A; Biologics Drug Product Development & Manufacturing, Global CMC, Sanofi, One Mountain Road, Framingham, MA 01701, USA. Electronic address: atul.saluja@sanofi.com.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Aug; Vol. 113 (8), pp. 2296-2304. Date of Electronic Publication: 2024 Mar 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/chemistry , Protein Stability* , Drug Stability* , Excipients*/chemistry, Temperature ; Kinetics ; Drug Design ; Protein Aggregates ; Chemistry, Pharmaceutical/methods ; Humans ; Animals

المؤلفون: Duan R; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Wang S; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Li Z; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Zhang W; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Wu J; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Jiang Y; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Lin Q; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Yuan P; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Yue X; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Yao Y; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Xiao X; School of Life Sciences, Tianjin University, Tianjin, 300072, China., Xiao Y; School of Life Sciences, Tianjin University, Tianjin, 300072, China. Electronic address: yunjiexiao2016@tju.edu.cn., Wang Z; School of Life Sciences, Tianjin University, Tianjin, 300072, China. Electronic address: zefangwang@tju.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Aug 20; Vol. 721, pp. 150109. Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Endopeptidase K*/metabolism , Endopeptidase K*/chemistry , Calcium*/metabolism , Calcium*/chemistry , Molecular Dynamics Simulation* , Enzyme Stability* , Protein Stability*, Computer-Aided Design ; Mutation ; Binding Sites ; Protein Engineering/methods ; Protein Conformation

المؤلفون: Manning MC; Legacy BioDesign LLC, Johnstown, CO, USA. manning@legacybiodesign.com.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA. manning@legacybiodesign.com., Holcomb RE; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Payne RW; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Stillahn JM; Legacy BioDesign LLC, Johnstown, CO, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Connolly BD; Spyre Therapeutics, Inc., Waltham, MA, USA., Katayama DS; Samsung Biologics, 201-2, Songdo-Dong, Yeonsu-Gu, Incheon, Korea., Liu H; Scholar Rock, Inc., Cambridge, MA, USA., Matsuura JE; Jim Matsuura Pharma Consulting LLC, Lafayette, CO, USA., Murphy BM; Just-Evotec, Seattle, WA, USA., Henry CS; Department of Chemistry, Colorado State University, Fort Collins, CO, USA., Crommelin DJA; Utrecht University, Utrecht, Netherlands.

المصدر: Pharmaceutical research [Pharm Res] 2024 Jul; Vol. 41 (7), pp. 1301-1367. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: Protein Stability* , Proteins*/chemistry , Drug Stability*, Humans ; Excipients/chemistry ; Drug Compounding/methods ; Chemistry, Pharmaceutical/methods ; Animals ; Antibodies, Monoclonal/chemistry

المؤلفون: Xie R; JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China., Lee YY; School of Science, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor, Malaysia., Xie P; JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China., Tan CP; Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia., Wang Y; JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China., Zhang Z; JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Aug 31; Vol. 29 (17). Date of Electronic Publication: 2024 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Enzymes, Immobilized*/chemistry , Enzymes, Immobilized*/metabolism , Lipase*/chemistry , Lipase*/metabolism , Diglycerides*/chemistry , Enzyme Stability*, Hydrogen-Ion Concentration ; Glycerol/chemistry ; Temperature ; Eurotiales/enzymology ; Biocatalysis ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism

SCR Organism: Thermomyces lanuginosus

المؤلفون: Jogdeo CM; Pharmaceutical Research and Development, Drug Product Design and Development Biotherapeutics Pharmaceutical Sciences, USA., Bhattacharya DS; Pharmaceutical Research and Development, Drug Product Design and Development Biotherapeutics Pharmaceutical Sciences, USA. Electronic address: deep.bhattacharya@pfizer.com., Lin V; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Kolhe P; Pharmaceutical Research and Development, Drug Product Design and Development Biotherapeutics Pharmaceutical Sciences, USA., Badkar A; Pharmaceutical Research and Development, Drug Product Design and Development Biotherapeutics Pharmaceutical Sciences, USA.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Jul; Vol. 113 (7), pp. 1854-1864. Date of Electronic Publication: 2024 Feb 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/chemistry , Protein Stability* , Drug Stability*, Injections, Subcutaneous ; Humans ; Chemistry, Pharmaceutical/methods