-
1دورية أكاديمية
المؤلفون: I. V. Brodyak, A. A. Moroz, A. Z. Kucharska, N. O. Sybirna
المصدر: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 17, Iss 2, Pp 154-159 (2024)
مصطلحات موضوعية: streptozotocin-induced diabetes mellitus, erythrocytes, nitric oxide synthase, nitrite anions, nitrate anions, extracts of fruits of cornelian cherry (cornus mas l.), Pharmacy and materia medica, RS1-441
وصف الملف: electronic resource
-
2دورية أكاديمية
المؤلفون: B.M. Verveha
المصدر: Вісник медичних і біологічних досліджень, Vol 3, Iss 2, Pp 11-15 (2021)
مصطلحات موضوعية: acute generalized peritonitis, streptozotocin-induced diabetes mellitus, morphological changes of the small intestine, Medicine (General), R5-920
وصف الملف: electronic resource
-
3دورية أكاديمية
المؤلفون: Irina Tymoshenko
المصدر: Ukrainian Scientific Medical Youth Journal, Iss 1(109), Pp 35-47 (2019)
مصطلحات موضوعية: burn injury, streptozotocin-induced diabetes mellitus, the mucous membrane of the duodenum, Medicine (General), R5-920, Internal medicine, RC31-1245
وصف الملف: electronic resource
-
4دورية أكاديمية
المؤلفون: M. M. Guzyk, T. M. Tykhonenko, K. O. Dyakun, L. V. Yanitska, I. B. Pryvrotska, T. M. Kuchmerovska
المصدر: The Ukrainian Biochemical Journal, Vol 91, Iss 1, Pp 21-29 (2019)
مصطلحات موضوعية: one of the serious complications of diabetes mellitus, is complex. In this study, we examined whether expression levels of SIRT1 and SIRT2 were the key for the development of brain dysfunctions and whether PARP-1 inhibitors could affect the expression of these proteins for prevention the development of DE in rats with type 1 diabetes. After 10 weeks of the streptozotocin-induced diabetes mellitus (70 mg/kg), Wistar male rats were treated by i.p. injection with PARP-1 inhibitors, 1.5-isoquinolinediol (ISO) or nicotinamide (NAm) (3 or 100 mg/kg/daily i.p., respectively) for 2 weeks. The rats with blood glucose levels over 19.7 ± 2.1 mmol/l were taken into experiments. Western blots were performed to evaluate effects of PAPR-1 inhibitors on the levels of sirtuins, SIRT1 and SIRT2 expression. Diabetes induced significant reduction of SIRT1 expression and SIRT2 overexpression in brain nuclear extracts of diabetic rats compared to non-diabetic control. In brain, NAm attenuated SIRT2 overexpression in nuclear extracts of diabetic rats and slightly elevated SIRT1 expression, while ISO didn’t affect expression of both sirtuins in diabetic rats. Furthermore, it was observed that in brain of diabetic rats, the ratio of free NAD/NADH couples decreased 3.1-fold compared to non-diabetic control. The administration of ISO increased only slightly the ratio of free NAD/NADH couples in the brain of diabetic rats while NAm increased this parameter 1.7-fold compared to diabetic rats. Therefore, 1.5-isoquinolinediol (ISO), diabetes mellitus, expression of sirtuins, nicotinamide (NAm), PARP-1 inhibitors, SIRT1, SIRT2, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
5دورية أكاديمية
المؤلفون: Ihor Bilinskyi
المصدر: Galician Medical Journal, Vol 27, Iss 4, Pp E2020413-E2020413 (2020)
مصطلحات موضوعية: streptozotocin-induced diabetes mellitus, duodenum, dystrophic changes, Medicine
وصف الملف: electronic resource
-
6دورية أكاديمية
المؤلفون: Skurikhin, E. G., Stronin, O. V., Epanchintsev, A. A., Pershina, O. V., Ermakova, N. N., Krupin, V. A., Pakhomova, A. V., Vaizova, O. E., Dygai, A. M.
المصدر: Bulletin of Experimental Biology and Medicine. :1-4
-
7دورية أكاديمية
المؤلفون: D. A. Putilin, A. M. Kamyshnyi
المصدر: Медицинская иммунология, Vol 18, Iss 4, Pp 339-346 (2016)
مصطلحات موضوعية: streptozotocin-induced diabetes mellitus, lymph nodes, pancreatic, glut1, mtor, ampk1α, gene expression, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
-
8دورية أكاديمية
المؤلفون: Putilin D.A., Kamyshny A.M.
المصدر: Морфологія, Vol 10, Iss 2, Pp 61-68 (2016)
مصطلحات موضوعية: experimental streptozotocin-induced diabetes mellitus, pancreatic lymph nodes, Glut1, mTOR, AMPK1α, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
9دورية أكاديمية
المؤلفون: Yurii Tkachuk
المصدر: Journal of Education, Health and Sport, Vol 6, Iss 4, Pp 375-384 (2016)
مصطلحات موضوعية: corticotrophs, adrenal glands, streptozotocin-induced diabetes mellitus., Education, Sports, GV557-1198.995, Medicine
وصف الملف: electronic resource
-
10
المصدر: Bukovinian Medical Herald; Vol. 13 No. 3 (51) (2009); 115-118
Буковинский медицинский вестник; Том 13 № 3 (51) (2009); 115-118
Буковинський медичний вісник; Том 13 № 3 (51) (2009); 115-118مصطلحات موضوعية: brain, carotid ischemia-reperfusion, streptozotocin-induced diabetes mellitus, proteolysis, fibrinolysis, головний мозок, каротидна ішемія-реперфузія, стрептозотоциновий цукровий діабет, протеоліз, фібриноліз
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=scientific_p::b88570d11c02313466e5a973851e0f00
http://e-bmv.bsmu.edu.ua/article/view/259088