المؤلفون: Gonciarz, Ryan L, Collisson, Eric A, Renslo, Adam R

المصدر: Trends in Pharmacological Sciences. 42(1)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Good Health and Well Being, Cell Death, Ferroptosis, Iron, Oxidation-Reduction, activity-based probes, ferritinophagy, ferroptosis, iron homeostasis, reactivity-based probes, targeted prodrugs, Biological Sciences, Medical and Health Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6sr173t6

المؤلفون: Christensen, Søren Brøgger^Aff24, Simonsen, Henrik Toft^Aff25, Engedal, Nikolai^Aff26, Nissen, Poul^Aff27, Møller, Jesper Vuust^Aff28, Denmeade, Samuel R.^Aff29, Isaacs, John T.^Aff29

المساهمون: Kinghorn, A. Douglas, Series Editor^{Aff1, Aff18}, Falk, Heinz, Series Editor^{Aff2, Aff19}, Gibbons, Simon, Series Editor^{Aff3, Aff20}, Asakawa, Yoshinori, Series Editor^{Aff4, Aff21}, Liu, Ji-Kai, Series Editor^{Aff5, Aff22}, Dirsch, Verena M., Series Editor^{Aff6, Aff23}, Appendino, Giovanni, Advisory Editor^Aff7, Berlinck, Roberto G. S., Advisory Editor^Aff8, Kobayashi, Jun'ichi, Advisory Editor^Aff9, Ludwiczuk, Agnieszka, Advisory Editor^Aff10, Naman, C. Benjamin, Advisory Editor^Aff11, Mata, Rachel, Advisory Editor^Aff12, Oberlies, Nicholas H., Advisory Editor^Aff13, Tasdemir, Deniz, Advisory Editor^Aff14, Trauner, Dirk, Advisory Editor^Aff15, Viljoen, Alvaro, Advisory Editor^Aff16, Ye, Yang, Advisory Editor^Aff17

المصدر: Progress in the Chemistry of Organic Natural Products 115. 115:59-114

المؤلفون: Fontaine, Shaun D, Spangler, Benjamin, Gut, Jiri, Lauterwasser, Erica MW, Rosenthal, Philip J, Renslo, Adam R

المصدر: ChemMedChem. 10(1)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Organic Chemistry, Chemical Sciences, Infectious Diseases, Vector-Borne Diseases, Rare Diseases, Orphan Drug, Malaria, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Antimalarials, Drug Carriers, Heterocyclic Compounds, 1-Ring, Kinetics, Microsomes, Liver, Peroxides, Plasmodium falciparum, Protozoan Proteins, Puromycin, Rats, Spiro Compounds, antimalarial agents, drug delivery, puromycin, targeted prodrugs, trioxolanes, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8410c4r5

المؤلفون: Deu, Edgar, Chen, Ingrid T, Lauterwasser, Erica MW, Valderramos, Juan, Li, Hao, Edgington, Laura E, Renslo, Adam R, Bogyo, Matthew

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 110(45)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Vector-Borne Diseases, Rare Diseases, Malaria, Biotechnology, Infectious Diseases, Orphan Drug, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Cancer, Infection, Good Health and Well Being, Animals, Delayed-Action Preparations, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Drug Delivery Systems, Drug Therapy, Combination, Electrophoresis, Polyacrylamide Gel, Ferrous Compounds, Heterocyclic Compounds, Mice, Photochemotherapy, Plasmodium berghei, iron-mediated delivery, targeted prodrugs, dipeptidyl peptidase, combination therapy

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9vs011c6

المؤلفون: John T. Isaacs, William Nathaniel Brennen, Søren Brøgger Christensen, Samuel R. Denmeade

المصدر: Molecules, Vol 26, Iss 24, p 7469 (2021)

مصطلحات موضوعية: Thapsigargin, Mipsagargin, tissue-specific proteases, targeted prodrugs, SERCA, Thapsia garganica, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/24/7469; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/73b6c006ea3d4efd966c5acdc0d1edd1

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المؤلفون: Adam R. Renslo, Ryan L. Gonciarz, Eric A. Collisson

المصدر: Trends in pharmacological sciences, vol 42, iss 1
Trends Pharmacol Sci

مصطلحات موضوعية: 0301 basic medicine, inorganic chemicals, Enzyme function, Iron, activity-based probes, Pharmacology, Toxicology, Medical and Health Sciences, Article, Ferrous, 03 medical and health sciences, 0302 clinical medicine, Iron homeostasis, Ferroptosis, Pharmacology & Pharmacy, ferritinophagy, Cell Death, Chemistry, reactivity-based probes, Biological Sciences, ferroptosis, 030104 developmental biology, Good Health and Well Being, Fenton chemistry, iron homeostasis, Oxidation-Reduction, 030217 neurology & neurosurgery, targeted prodrugs

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6432a5290dfa298da87405a9c186279
https://escholarship.org/uc/item/6sr173t6

المؤلفون: Samuel R. Denmeade, Søren Brøgger Christensen, John T. Isaacs, Jesper V. Møller, Henrik Toft Simonsen, Nikolai Engedal, Poul Nissen

المساهمون: Kinghorn, A.D., Falk, H., Gibbons, S., Asakawa, Y., Liu, J.K., Dirsch, V.M.

المصدر: Progress in the Chemistry of Organic Natural Products 115 ISBN: 9783030648527
Christensen, S B, Simonsen, H T, Engedal, N, Nissen, P, Møller, J V, Denmeade, S R & Isaacs, J T 2021, From Plant to Patient : Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development . in A D Kinghorn, H Falk, S Gibbons, Y Asakawa, J K Liu & V M Dirsch (eds), Progress in the Chemistry of Organic Natural Products . vol. 115, Springer, Cham, pp. 59-114 . https://doi.org/10.1007/978-3-030-64853-4_2

مصطلحات موضوعية: Sarco-endoplasmic reticulum calcium ATPase, Thapsigargin, SERCA, biology, ATPase, Endoplasmic reticulum, Apoptosis, Drug development, Mipsagargin, chemistry.chemical_compound, Mechanism of action, chemistry, Biochemistry, cardiovascular system, Unfolded protein response, medicine, biology.protein, Targeted prodrugs, medicine.symptom, Secretory pathway, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c82d37d058a4501f7d785e49d7bb59c
https://doi.org/10.1007/978-3-030-64853-4_2

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المؤلفون: Erica M. W. Lauterwasser, Adam R. Renslo, Jiri Gut, Benjamin Spangler, Shaun D. Fontaine, Philip J. Rosenthal

المصدر: ChemMedChem, vol 10, iss 1

مصطلحات موضوعية: Protozoan Proteins, Pharmacology, Biochemistry, chemistry.chemical_compound, Heterocyclic Compounds, trioxolanes, Drug Discovery, 2.2 Factors relating to the physical environment, Antimalarial Agent, Aetiology, General Pharmacology, Toxicology and Pharmaceutics, Artemisinin, 1-Ring, Drug Carriers, biology, Pharmacology and Pharmaceutical Sciences, Peroxides, Infectious Diseases, Liver, Puromycin, Drug delivery, Microsomes, Liver, Molecular Medicine, Infection, Drug carrier, targeted prodrugs, medicine.drug, Medicinal & Biomolecular Chemistry, Plasmodium falciparum, puromycin, Article, Medicinal and Biomolecular Chemistry, Antimalarials, Heterocyclic Compounds, 1-Ring, Rare Diseases, Microsomes, parasitic diseases, medicine, Animals, Spiro Compounds, antimalarial agents, Arterolane, Organic Chemistry, biology.organism_classification, Malaria, Rats, Vector-Borne Diseases, Kinetics, Orphan Drug, Good Health and Well Being, Targeted drug delivery, chemistry, drug delivery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26546d3842235ca9f8d67ec878eb3620
https://doi.org/10.1002/cmdc.201402362