المؤلفون: Maclean KN; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA., Jiang H; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA., Neill PD; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA., Chanin RR; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA., Hurt KJ; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado, USA., Orlicky DJ; Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado, USA., Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, Texas, USA., Roede JR; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA., Stabler SP; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jul 15; Vol. 38 (13), pp. e23795.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Homocystinuria*/metabolism , Homocystinuria*/drug therapy , Homocystinuria*/genetics , Tetrahydrofolates*/metabolism , Liver*/metabolism , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics , Oxidation-Reduction*, Animals ; Mice ; Betaine/metabolism ; Betaine/pharmacology ; Homocysteine/metabolism ; Mice, Inbred C57BL ; Cystathionine beta-Synthase/metabolism ; Cystathionine beta-Synthase/genetics ; Carbon/metabolism ; Male ; Folic Acid/metabolism ; Female

المؤلفون: Aoki Y; AntiCancer Inc, San Diego, CA, U.S.A.; yaoki0630@gmail.com.; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A.; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Kubota Y; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A., Masaki N; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A., Obara K; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A., Tome Y; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan yastome@med.u-ryukyu.ac.jp., Bouvet M; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A., Nishida K; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Hoffman RM; AntiCancer Inc, San Diego, CA, U.S.A.; all@anticancer.com.; Department of Surgery, University of California, San Diego, La Jolla, CA, U.S.A.

المصدر: Anticancer research [Anticancer Res] 2024 Jul; Vol. 44 (7), pp. 2787-2792.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Osteosarcoma*/metabolism , Osteosarcoma*/genetics , Methotrexate*/pharmacology , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics , Drug Resistance, Neoplasm*/drug effects , TOR Serine-Threonine Kinases*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics, Humans ; Animals ; Cell Line, Tumor ; Mice ; Xenograft Model Antitumor Assays ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Bone Neoplasms/metabolism ; Bone Neoplasms/genetics ; Gene Amplification ; Signal Transduction/drug effects ; Mice, Nude ; Antimetabolites, Antineoplastic/pharmacology

المؤلفون: Joste V; Université Paris Cité, IRD, MERIT, Paris, France; Centre National de Référence du Paludisme, AP-HP, Hôpital Bichat - Claude-Bernard, Paris, France. Electronic address: valentinjoste@gmail.com., Coppée R; Université de Rouen Normandie, Laboratoire de Parasitologie-Mycologie, UR 7510 ESCAPE, Centre Hospitalier Universitaire de Rouen, Rouen, France., Bailly J; Université Paris Cité, IRD, MERIT, Paris, France., Rakotoarivony Y; Centre National de Référence du Paludisme, AP-HP, Hôpital Bichat - Claude-Bernard, Paris, France., Toko Tchokoteu FG; Université Paris Cité, IRD, MERIT, Paris, France., Achache S; Université Paris Cité, IRD, MERIT, Paris, France., Pradines B; Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées (IRBA), Marseille, France; Université Aix-Marseille, IRD, SSA, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Centre National de Référence du Paludisme, Marseille, France., Cottrell G; Université Paris Cité, IRD, MERIT, Paris, France., Ariey F; INSERM U1016, Institut Cochin, Laboratoire de Parasitologie-Mycologie, Hôpital Cochin, AP-HP, Université Paris Cité, Paris, France., Khim N; Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Popovici J; Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Mita T; Department of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan., Groger M; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ramharter M; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Egbo T; Walter Reed Army Institute of Research - Africa (WRAIR-A), Kisumu, Kenya., Juma DW; Department of Emerging and Infectious Diseases (DEID), Walter Reed Army Institute of Research - Africa (WRAIR-A), Kisumu, Kenya., Akala H; Department of Emerging and Infectious Diseases (DEID), Walter Reed Army Institute of Research - Africa (WRAIR-A), Kisumu, Kenya., Houzé S; Université Paris Cité, IRD, MERIT, Paris, France; Centre National de Référence du Paludisme, AP-HP, Hôpital Bichat - Claude-Bernard, Paris, France., Clain J; Université Paris Cité, IRD, MERIT, Paris, France; Centre National de Référence du Paludisme, AP-HP, Hôpital Bichat - Claude-Bernard, Paris, France.

مؤلفون مشاركون: Investigation Study Group

المصدر: The Lancet. Microbe [Lancet Microbe] 2024 Jul; Vol. 5 (7), pp. 669-678. Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/genetics , Tetrahydrofolate Dehydrogenase*/metabolism , Pyrimethamine*/pharmacology , Pyrimethamine*/therapeutic use , Drug Resistance*/genetics , Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Mutation* , Plasmodium ovale*/genetics , Plasmodium ovale*/drug effects , Malaria*/epidemiology, Humans ; Retrospective Studies ; Africa South of the Sahara/epidemiology ; Protozoan Proteins/genetics ; Kenya/epidemiology

المؤلفون: Bakr RB; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., El Azab IH; Department of Food Science and Nutrition, College of Science, Taif University, P.O. Box: 11099, 21944, Taif, Saudi Arabia., Elkanzi NAA; Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia.; Chemistry Department, Faculty of Science, Aswan University, P.O. Box: 81528, Aswan, Egypt.

المصدر: Chemistry & biodiversity [Chem Biodivers] 2024 Jun; Vol. 21 (6), pp. e202400200. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

مواضيع طبية MeSH: Quinolines*/chemistry , Quinolines*/pharmacology , DNA Gyrase*/metabolism , DNA Gyrase*/chemistry , Microbial Sensitivity Tests* , Molecular Docking Simulation* , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/chemistry , Candida albicans*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis, Structure-Activity Relationship ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/chemical synthesis ; Molecular Structure ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/chemical synthesis ; Dose-Response Relationship, Drug

المؤلفون: Kazmirchuk TDD; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Burnside DJ; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Wang J; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Jagadeesan SK; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Al-Gafari M; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Silva E; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Potter T; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Bradbury-Jost C; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Ramessur NB; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Ellis B; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Takallou S; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Hajikarimlou M; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Moteshareie H; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Said KB; Department of Pathology and Microbiology, University of Hail, 55476, Hail, Saudi Arabia., Samanfar B; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada.; Agriculture and Agri-Food Canada, Ottawa, K1A 0C6, Canada., Fletcher E; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada., Golshani A; Department of Biology and the Ottawa Institute of Systems Biology (OISB), Carleton University, Ottawa, K1S 5B6, Canada. ashkan.golshani@carleton.ca.

المصدر: Scientific reports [Sci Rep] 2024 May 22; Vol. 14 (1), pp. 11695. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/drug effects , Saccharomyces cerevisiae*/metabolism , Molecular Docking Simulation*, Folic Acid Antagonists/pharmacology ; RNA/metabolism ; Humans ; Fungicides, Industrial/pharmacology ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/genetics

المؤلفون: Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia., Avunoori S; Department of Pharmaceutical Chemistry, Novel Drug Design and Discovery Laboratory, SET's College of Pharmacy, Sangolli Rayanna Nagar, Dharwad, Karnataka, India., Gopi S; Department of Pharmaceutical Chemistry, Novel Drug Design and Discovery Laboratory, SET's College of Pharmacy, Sangolli Rayanna Nagar, Dharwad, Karnataka, India., Shaikh IA; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia., Saif A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Bantun F; Faculty of Medicine, Department of Microbiology, Umm Al-Qura University, Makkah, Saudi Arabia., Faidah HS; Faculty of Medicine, Department of Microbiology, Umm Al-Qura University, Holy Makkah, Kingdom of Saudi Arabia., Alhadi AA; Faculty of Medicine, Department of Microbiology, Umm Al-Qura University, Holy Makkah, Kingdom of Saudi Arabia., Alshehri JH; Microbiology Section Pathology and Laboratory Medicine, Armed Forces Hospital Southern Region, Khamis Mushait, Kingdom of Saudi Arabia., Alharbi AA; Microbiology Section Pathology and Laboratory Medicine, Armed Forces Hospital Southern Region, Khamis Mushait, Kingdom of Saudi Arabia., S R PK; Department of Pharmaceutical Chemistry, MVM College of Pharmacy, Yelahanka, Bengaluru, Karnataka, India., Joshi SD; Department of Pharmaceutical Chemistry, Novel Drug Design and Discovery Laboratory, SET's College of Pharmacy, Sangolli Rayanna Nagar, Dharwad, Karnataka, India.

المصدر: PloS one [PLoS One] 2024 May 13; Vol. 19 (5), pp. e0303173. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Pyrroles*/chemical synthesis , Pyrroles*/chemistry , Pyrroles*/pharmacology , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/chemistry, Humans ; Catalytic Domain ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/antagonists & inhibitors ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/metabolism ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/chemistry ; Folic Acid Antagonists/pharmacology ; Folic Acid Antagonists/chemistry ; Folic Acid Antagonists/chemical synthesis ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/enzymology ; Structure-Activity Relationship

المؤلفون: Babu CS; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan., Chen JY; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan., Lim C; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

المصدر: The journal of physical chemistry. B [J Phys Chem B] 2024 May 02; Vol. 128 (17), pp. 4111-4122. Date of Electronic Publication: 2024 Apr 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/chemistry , Escherichia coli*/enzymology , Molecular Dynamics Simulation* , Protein Conformation*, Osmolar Concentration ; Solutions ; Calcium Chloride/chemistry ; Calcium Chloride/metabolism

المؤلفون: Meng XN; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Ma JF; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Liu YH; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Li SQ; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Wang X; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Zhu J; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Cai MD; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Zhang HS; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Song T; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Xing S; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Hou LQ; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Guo H; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Cui XB; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Han J; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Liu P; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Ji GH; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Sun WJ; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China., Yu JC; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.; Scientific Research Centre, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China., Fu SB; Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China. fusb@ems.hrbmu.edu.cn.; Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China. fusb@ems.hrbmu.edu.cn.

المصدر: British journal of cancer [Br J Cancer] 2024 May; Vol. 130 (11), pp. 1819-1827. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Methotrexate*/pharmacology , Drug Resistance, Neoplasm*/genetics , Tetrahydrofolate Dehydrogenase*/genetics , Tetrahydrofolate Dehydrogenase*/metabolism , Gene Amplification*, Humans ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Antimetabolites, Antineoplastic/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Genomics/methods

المؤلفون: Chain C; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Sheehan JP; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Xu X; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Chemistry, Princeton University, Princeton, NJ, USA., Ghaffari S; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Godbole A; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Kim H; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Small Molecule Screening Center, Princeton University, Princeton, NJ, USA., Freundlich JS; Department of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ, USA.; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ, USA., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA., Gitai Z; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. zgitai@princeton.edu.

المصدر: Nature microbiology [Nat Microbiol] 2024 May; Vol. 9 (5), pp. 1207-1219. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Pseudomonas aeruginosa*/metabolism , Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/genetics , Pseudomonas Infections*/microbiology , Pseudomonas Infections*/drug therapy , Anti-Bacterial Agents*/pharmacology , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics , Microbial Sensitivity Tests*, Animals ; Mice ; Folic Acid Antagonists/pharmacology ; Folic Acid/metabolism ; Drug Resistance, Bacterial ; Disease Models, Animal ; Thymine/metabolism ; Humans ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Female

المؤلفون: Fouad MM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: dr.mahasen_m.f@mans.edu.eg., Ghabbour HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Shehata IA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., El-Ashmawy MB; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Jul; Vol. 148, pp. 107401. Date of Electronic Publication: 2024 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Tetrahydrofolate Dehydrogenase*/metabolism , Drug Screening Assays, Antitumor* , Folic Acid Antagonists*/pharmacology , Folic Acid Antagonists*/chemical synthesis , Folic Acid Antagonists*/chemistry , Cell Proliferation*/drug effects , Molecular Docking Simulation*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Apoptosis/drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry