المؤلفون: Yadav S; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., El Hamra R; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Alturki NA; Clinical Laboratory Science Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Ariana A; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Bhan A; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Hurley K; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Gaestel M; Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany., Blackshear PJ; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, United States of America., Blais A; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, Ottawa, ON, Canada.; University of Ottawa, Centre for Infection Immunity and Inflammation, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada., Sad S; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. subash.sad@uottawa.ca.; University of Ottawa, Centre for Infection Immunity and Inflammation, Ottawa, ON, Canada. subash.sad@uottawa.ca.

المصدر: Cell death & disease [Cell Death Dis] 2024 Aug 08; Vol. 15 (8), pp. 574. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Tristetraprolin*/metabolism , Tristetraprolin*/genetics , Necroptosis* , Cytokines*/metabolism , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/genetics, Animals ; Mice ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Macrophages/metabolism ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/genetics ; RAW 264.7 Cells ; Up-Regulation/drug effects ; Interferon-beta/metabolism ; Mice, Inbred C57BL ; Gene Expression Regulation

المؤلفون: Alessi DR; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, USA.; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, United Kingdom; email: d.r.alessi@dundee.ac.uk., Pfeffer SR; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, USA.; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA.

المصدر: Annual review of biochemistry [Annu Rev Biochem] 2024 Aug; Vol. 93 (1), pp. 261-287. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985150R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-4509 (Electronic) Linking ISSN: 00664154 NLM ISO Abbreviation: Annu Rev Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/chemistry , Parkinson Disease*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/pathology , rab GTP-Binding Proteins*/metabolism , rab GTP-Binding Proteins*/genetics , rab GTP-Binding Proteins*/chemistry, Humans ; Phosphorylation ; Animals ; Signal Transduction ; Mutation ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/chemistry ; Protein Binding ; Phosphoprotein Phosphatases/metabolism ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/chemistry

المؤلفون: Yao Y; Hebei Key Laboratory of Public Health Safety, Ministry of Education & College of Public Health, Hebei University, Baoding 071002, China., Liu X; Hebei Key Laboratory of Public Health Safety, Ministry of Education & College of Public Health, Hebei University, Baoding 071002, China., Niu X; Hebei Key Laboratory of Public Health Safety, Ministry of Education & College of Public Health, Hebei University, Baoding 071002, China., Li Y; Hebei Key Laboratory of Public Health Safety, Ministry of Education & College of Public Health, Hebei University, Baoding 071002, China., Han L; Hebei Key Laboratory of Public Health Safety, Ministry of Education & College of Public Health, Hebei University, Baoding 071002, China.

المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 03; Vol. 72 (26), pp. 14747-14759. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy*/drug effects , Lycopene*/pharmacology , Macrophages*/drug effects , Macrophages*/immunology , Receptor-Interacting Protein Serine-Threonine Kinases*/genetics , Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism , Signal Transduction*/drug effects, Animals ; Mice ; RAW 264.7 Cells ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/genetics ; Beclin-1/genetics ; Beclin-1/metabolism

المؤلفون: Iacono D; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA; Neuroscience Program, Department of Anatomy, Physiology & Genetics, Uniformed Services University (USU), Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA. Electronic address: diego.iacono.ctr@usuhs.edu., Murphy EK; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA., Stimpson CD; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA., Perl DP; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA., Day RM; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.

المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Jul; Vol. 124, pp. 107024. Date of Electronic Publication: 2024 Jun 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

مواضيع طبية MeSH: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , Parkinson Disease*/metabolism , Parkinson Disease*/genetics, Animals ; Female ; Male ; alpha-Synuclein/metabolism ; Corpus Striatum/metabolism ; Corpus Striatum/radiation effects ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Swine ; Tyrosine 3-Monooxygenase/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Rukhsana; Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University, 209-Neungdong-ro, Gwangjin-gu, 05006, Seoul, Korea.; College of Science and Engineering, University of Derby, Kedleston Road, Derby, DE22 1GB, UK., Supty AT; Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University, 209-Neungdong-ro, Gwangjin-gu, 05006, Seoul, Korea., Hussain M; College of Science and Engineering, University of Derby, Kedleston Road, Derby, DE22 1GB, UK. m.hussain@derby.ac.uk., Lee Y; Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University, 209-Neungdong-ro, Gwangjin-gu, 05006, Seoul, Korea. yjlee@sejong.ac.kr.

المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Jul; Vol. 206 (1), pp. 119-129. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers, Tumor*/genetics , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality , Breast Neoplasms*/metabolism , Carcinoma, Ductal, Breast*/genetics , Carcinoma, Ductal, Breast*/pathology , Carcinoma, Ductal, Breast*/mortality , Carcinoma, Ductal, Breast*/metabolism , Gene Expression Regulation, Neoplastic* , Serine-Threonine Kinase 3*/analysis , Serine-Threonine Kinase 3*/genetics, Aged ; Female ; Humans ; Middle Aged ; Gene Expression Profiling ; Kaplan-Meier Estimate ; Neoplasm Staging ; Prognosis ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism

المؤلفون: Kang J; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Huang G; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Ma L; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Tong Y; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Shahapal A; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Chen P; Department of Neurology, Brigham and Women's Hospital, Boston, United States., Shen J; Department of Neurology, Brigham and Women's Hospital, Boston, United States.; Program in Neuroscience, Harvard Medical School, Boston, United States.

المصدر: ELife [Elife] 2024 Jun 10; Vol. 12. Date of Electronic Publication: 2024 Jun 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Dopaminergic Neurons*/metabolism , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , Mice, Knockout* , Cell Survival*, Animals ; Mice ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Apoptosis

المؤلفون: Artins A; Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Golm, Germany., Martins MCM; in Press - Scientific Consulting and Communication Services, 05089-030, São Paulo, São Paulo, Brazil., Meyer C; Institut Jean-Pierre Bourgin (IJPB), INRAE, AgroParisTech, Université Paris-Saclay, 78000, Versailles, France., Fernie AR; Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Golm, Germany., Caldana C; Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Golm, Germany.

المصدر: The Plant journal : for cell and molecular biology [Plant J] 2024 Jun; Vol. 118 (5), pp. 1268-1280. Date of Electronic Publication: 2024 Feb 13.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE

مواضيع طبية MeSH: Carbon*/metabolism , Nitrogen*/metabolism , Photosynthesis* , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Signal Transduction*, Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Plants/metabolism ; Plants/genetics ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/genetics

المؤلفون: Zhao Z; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Chu Y; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Feng A; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Zhang S; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Wu H; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Li Z; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Sun M; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Zhang L; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Chen T; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. chentao@tongji.edu.cn., Xu M; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. 1800512@tongji.edu.cn.

المصدر: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2024 Aug; Vol. 47 (4), pp. 1295-1314. Date of Electronic Publication: 2024 Mar 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3436 (Electronic) Linking ISSN: 22113428 NLM ISO Abbreviation: Cell Oncol (Dordr) Subsets: MEDLINE

مواضيع طبية MeSH: Forkhead Box Protein O1*/metabolism , Forkhead Box Protein O1*/genetics , Cell Proliferation*/genetics , Esophageal Squamous Cell Carcinoma*/pathology , Esophageal Squamous Cell Carcinoma*/genetics , Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/genetics , Esophageal Neoplasms*/metabolism , Serine-Threonine Kinase 3* , Heat-Shock Proteins*/metabolism , Heat-Shock Proteins*/genetics , Signal Transduction*/genetics , Mice, Nude*, Humans ; Animals ; Cell Line, Tumor ; Female ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Mice ; Male ; Carrier Proteins/metabolism ; Carrier Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Apoptosis/genetics ; Cell Movement/genetics ; Mice, Inbred BALB C

المؤلفون: Chen M; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Shen C; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address: chashen@coh.org., Chen Y; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China., Chen Z; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Zhou K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA., Chen Y; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China., Li W; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Zeng C; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Hematology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, China., Qing Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Wu D; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China., Xu C; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, CA 91016, USA., Tang T; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Che Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Qin X; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Xu Z; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Wang K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Leung K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Sau L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Deng X; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address: xideng@coh.org., Hu J; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China; Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China. Electronic address: drjiandahu@163.com., Wu Y; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China. Electronic address: wuyong9195@126.com., Chen J; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address: jianchen@coh.org.

المصدر: Cell reports. Medicine [Cell Rep Med] 2024 Jul 16; Vol. 5 (7), pp. 101645.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/pharmacology , Metformin*/therapeutic use , fms-Like Tyrosine Kinase 3*/genetics , fms-Like Tyrosine Kinase 3*/metabolism , fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , Proto-Oncogene Proteins*/metabolism , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/antagonists & inhibitors , Polo-Like Kinase 1* , Drug Synergism* , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Signal Transduction*/drug effects , Pyrazines*/pharmacology , Pyrazines*/therapeutic use , Aniline Compounds*/pharmacology , Aniline Compounds*/therapeutic use , Mutation*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; STAT5 Transcription Factor/metabolism ; STAT5 Transcription Factor/genetics ; Female ; Xenograft Model Antitumor Assays ; Male ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; TOR Serine-Threonine Kinases/metabolism

المؤلفون: Li Z; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Su P; Department of Pathology, Shandong University Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China., Yu M; Department of General Surgery, Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China., Zhang X; Kidney Transplantation, Second Hospital, Cheloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, P.R. China., Xu Y; Department of Clinical Laboratory, Second Hospital, Cheloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, P.R. China., Jia T; Department of Clinical Laboratory, Second Hospital, Cheloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, P.R. China., Yang P; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Zhang C; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Sun Y; Department of Pathology, Shandong University Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China., Li X; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Yang H; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Ding Y; Department of General Surgery, Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China., Zhuang T; Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China., Guo H; Department of Clinical Laboratory, Second Hospital, Cheloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, P.R. China., Zhu J; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, PR China.

المصدر: Science signaling [Sci Signal] 2024 Jul 02; Vol. 17 (843), pp. eadk0231. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/pathology , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/genetics , Kidney Neoplasms*/pathology , Transcription Factors*/metabolism , Transcription Factors*/genetics , YAP-Signaling Proteins*/metabolism , YAP-Signaling Proteins*/genetics , Cell Proliferation* , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics, Humans ; Animals ; Transcription Factor RelA/metabolism ; Transcription Factor RelA/genetics ; Mice ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Hippo Signaling Pathway ; Signal Transduction ; TEA Domain Transcription Factors/metabolism ; NF-kappa B/metabolism ; NF-kappa B/genetics ; Mice, Nude ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Serine-Threonine Kinase 3