المؤلفون: Gambles MT; Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT, 84112, USA.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, 84112, USA., Sborov D; Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Shami P; Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Yang J; Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT, 84112, USA.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, 84112, USA., Kopeček J; Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT, 84112, USA.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, 84112, USA.; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 84112, USA.

المصدر: Macromolecular bioscience [Macromol Biosci] 2024 Mar; Vol. 24 (3), pp. e2300375. Date of Electronic Publication: 2023 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101135941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1616-5195 (Electronic) Linking ISSN: 16165187 NLM ISO Abbreviation: Macromol Biosci Subsets: MEDLINE

مواضيع طبية MeSH: Topoisomerase Inhibitors* , Antineoplastic Agents*, Humans ; Animals ; Mice ; Antigens, CD20/genetics ; Morpholinos ; Antibodies, Monoclonal, Humanized/pharmacology ; Macromolecular Substances ; DNA

المؤلفون: Zorman M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia., Hrast Rambaher M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia., Kokot M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia., Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia. Electronic address: nikola.minovski@ki.si., Anderluh M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia. Electronic address: marko.anderluh@ffa.uni-lj.si.

المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jan 01; Vol. 192, pp. 106632. Date of Electronic Publication: 2023 Nov 09.

نوع المنشور: Review; Journal Article

بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Topoisomerase Inhibitors*/pharmacology , Topoisomerase Inhibitors*/therapeutic use , Topoisomerase Inhibitors*/chemistry , Methicillin-Resistant Staphylococcus aureus*, Mice ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/chemistry ; DNA Gyrase/chemistry ; DNA Gyrase/pharmacology ; Zebrafish ; Gram-Positive Bacteria ; Gram-Negative Bacteria ; Microbial Sensitivity Tests ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use

المؤلفون: Dos Santos JC; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., Alves JEF; Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, PE, Brazil., de Azevedo RDS; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., de Lima ML; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., de Oliveira Silva MR; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., da Silva JG; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., da Silva JM; Department of Pharmacy, Laboratory of Synthesis and Vectorization of Molecules, State University of Paraíba (UEPB), Campus Campina Grande, 58429-500, PB, Brazil., de Carvalho Correia AC; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., do Carmo Alves de Lima M; Chemistry and Therapeutic Innovation Laboratory (LQIT), Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil., de Oliveira JF; University of International Integration of Afro-Brazilian Lusophony (UNILAB), 62790-970 Redenção, CE, Brazil., de Moura RO; Department of Pharmacy, Laboratory of Synthesis and Vectorization of Molecules, State University of Paraíba (UEPB), Campus Campina Grande, 58429-500, PB, Brazil., de Almeida SMV; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil; Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, PE, Brazil; Chemistry and Therapeutic Innovation Laboratory (LQIT), Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: sinara.monica@upe.br.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 254 (Pt 3), pp. 127651. Date of Electronic Publication: 2023 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Topoisomerase Inhibitors*/pharmacology , Topoisomerase Inhibitors*/chemistry , Antineoplastic Agents*/chemistry, Structure-Activity Relationship ; Molecular Docking Simulation ; DNA/chemistry ; Intercalating Agents/pharmacology ; Acridines/pharmacology ; Acridines/chemistry ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Structure

المؤلفون: Santos MB; Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil., de Azevedo Teotônio Cavalcanti M; Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil., de Medeiros E Silva YMS; Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil., Dos Santos Nascimento IJ; Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Departament of Pharmacy, Cesmac University Center, Maceió, Brazil., de Moura RO; Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, 58429-500, Brazil.; Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.

المصدر: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2024; Vol. 24 (4), pp. 236-262.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Topoisomerase Inhibitors*/pharmacology , Topoisomerase Inhibitors*/chemistry , Topoisomerase Inhibitors*/chemical synthesis , Heterocyclic Compounds*/chemistry , Heterocyclic Compounds*/pharmacology , Heterocyclic Compounds*/chemical synthesis, Humans ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; DNA Topoisomerases, Type I/metabolism ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Animals

المؤلفون: Mann CA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Carvajal Moreno JJ; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Dellos-Nolan S; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University , Columbus, Ohio, USA., Wozniak DJ; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University , Columbus, Ohio, USA., Yalowich JC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Oct 18; Vol. 67 (10), pp. e0048223. Date of Electronic Publication: 2023 Sep 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Topoisomerase Inhibitors*/pharmacology , DNA Gyrase*/metabolism, Humans ; DNA Topoisomerase IV ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Staphylococcus aureus/metabolism ; DNA ; Amides/pharmacology ; Topoisomerase II Inhibitors/pharmacology ; Microbial Sensitivity Tests

المؤلفون: Phelps HA; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Kuhn M; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States., Vibhute S; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States., Watts JL; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States. Electronic address: mitton-fry.1@osu.edu.

المصدر: Veterinary microbiology [Vet Microbiol] 2023 Sep; Vol. 284, pp. 109840. Date of Electronic Publication: 2023 Jul 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Topoisomerase Inhibitors*/pharmacology , Bacteria*, Animals ; Humans ; Structure-Activity Relationship ; Anti-Bacterial Agents/pharmacology ; Gram-Positive Bacteria ; Microbial Sensitivity Tests/veterinary

المؤلفون: Yun Y; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Wang M; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Guo S; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Xie X; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.; State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 18; Vol. 29 (12). Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing*/methods , CRISPR-Cas Systems* , Proto-Oncogene Proteins c-pim-1*/antagonists & inhibitors , Proto-Oncogene Proteins c-pim-1*/genetics , Proto-Oncogene Proteins c-pim-1*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry, Animals ; Mice ; Topoisomerase Inhibitors/pharmacology ; Humans ; Recombinational DNA Repair/drug effects ; Gene Knock-In Techniques

المؤلفون: Singh SB; Merck & Co., Inc., Kenilworth, NJ 07033, USA. Electronic address: sbsingh101@gmail.com., Tan CM; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Kaelin D; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Meinke PT; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Miesel L; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Olsen DB; Merck & Co., Inc., West Point, PA 19486, USA., Fukuda H; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Kishii R; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takei M; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Ohata K; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takeuchi T; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Shibue T; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takano H; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Nishimura A; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Fukuda Y; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: yasumichi.fukuda@gmail.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 01; Vol. 75, pp. 128808. Date of Electronic Publication: 2022 May 21.

نوع المنشور: Clinical Trial, Phase III; Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Topoisomerase Inhibitors*/chemistry , Topoisomerase Inhibitors*/pharmacology, DNA Gyrase/metabolism ; DNA Topoisomerase IV ; Microbial Sensitivity Tests ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship ; Thioinosine/analogs & derivatives ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology

المؤلفون: Wang J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China.; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Peking University Health Science Center, Beijing, P.R. China., Xu J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China., Yang S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China.; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Peking University Health Science Center, Beijing, P.R. China., He L; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China., Xu W; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China.; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Peking University Health Science Center, Beijing, P.R. China., Liu Y; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China., Cao B; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China., Yu S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, P.R. China.; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Peking University Health Science Center, Beijing, P.R. China.

المصدر: Molecular carcinogenesis [Mol Carcinog] 2024 Apr; Vol. 63 (4), pp. 742-756. Date of Electronic Publication: 2024 Jan 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics, Animals ; Mice ; Humans ; Irinotecan/pharmacology ; Camptothecin/pharmacology ; Mitomycin/pharmacology ; Mice, Nude ; NF-E2-Related Factor 2/genetics ; Drug Resistance, Neoplasm ; Topoisomerase Inhibitors/pharmacology ; Drug Combinations

المؤلفون: Rabassa-Blanco J; Department of Pediatric Dentistry, Hospital Sant Joan de Déu (HSJD), University of Barcelona, Barcelona, Spain.; Department of Odontostomatology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Brunet-Llobet L; Department of Pediatric Dentistry, Hospital Sant Joan de Déu (HSJD), University of Barcelona, Barcelona, Spain.; Hospital Dentistry, Clinical Orthodontics, and Periodontal Medicine Research Group (HDCORPEMrg), Institut de Recerca Sant Joan de Déu (IRSJD), Barcelona, Spain., Marcote-Sinclair P; Department of Pediatric Oncology, Developmental Cancer Survivors Unit, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain., Balsells-Mejía S; Department of Research Promotion and Management. Statistical Support, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain., Correa-Llano MG; Department of Pediatric Oncology, Hospital Sant Joan de Déu (HSJD), Barcelona, Spain., Miranda-Rius J; Department of Odontostomatology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Hospital Dentistry, Clinical Orthodontics, and Periodontal Medicine Research Group (HDCORPEMrg), Institut de Recerca Sant Joan de Déu (IRSJD), Barcelona, Spain.

المصدر: Oral diseases [Oral Dis] 2024 Mar; Vol. 30 (2), pp. 604-614. Date of Electronic Publication: 2022 Aug 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis

مواضيع طبية MeSH: Tooth Abnormalities* , Neoplasms*/therapy, Child ; Humans ; Child, Preschool ; Adolescent ; Retrospective Studies ; Antibiotics, Antineoplastic ; Prevalence ; Risk Factors ; Alkylating Agents ; Topoisomerase Inhibitors