المؤلفون: Alex Sirp, Anastassia Shubina, Jürgen Tuvikene, Laura Tamberg, Carl Sander Kiir, Laura Kranich, Tõnis Timmusk

المصدر: Frontiers in Molecular Neuroscience, Vol 15 (2022)

مصطلحات موضوعية: transcription factor TCF4, basic helix–loop–helix transcription factor, western blot analysis, neurodevelopment, long-read RNA sequencing, brain tissue, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.1033224/full; https://doaj.org/toc/1662-5099

URL الوصول: https://doaj.org/article/9b778188fd544b8fa16f929f6f9ccfae

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المؤلفون: Jürgen Tuvikene, Kaisa Roots, Tõnis Timmusk, Alex Sirp, Kaja Nurm, Mari Sepp

المصدر: The Journal of Biological Chemistry
Journal of Biological Chemistry
UnpayWall
ORCID
Microsoft Academic Graph
PubMed Central

مصطلحات موضوعية: Transcription, Genetic, TCF4, Transcription factor 4, neurocognitive disorders, Pitt–Hopkins syndrome, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, Transcription Factor 4, Intellectual disability, Missense mutation, Hyperventilation, Genetics, Mutation, Helix-Loop-Helix Motifs, TCF4, single-nucleotide polymorphism, transcription factor TCF4, SCZ, Schizophrenia, CE, conserved element, PGK, phosphoglycerine kinase, MMID, Mild-to-moderate intellectual disability, Research Article, Gene isoform, basic helix-loop-helix transcription factor, RTT-like, Rett-like syndrome, Mutation, Missense, autism, TK, thymidine kinase, Single-nucleotide polymorphism, NLS, Nuclear localization signal, Biology, PBST, PBS with Tween 20, bHLH, basic helix-loop-helix, PTHS, Pitt-Hopkins syndrome, Intellectual Disability, Pitt-Hopkins syndrome, medicine, Animals, Humans, Molecular Biology, Transcription factor, missense mutation, Facies, Cell Biology, AD, activation domain, medicine.disease, neuron, Rats, schizophrenia, HEK293 Cells, Amino Acid Substitution, ASCL1, achaete-scute homolog 1, BSA, bovine serum albumin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571fb9a500003d0acbefc612aacd700e
https://pubmed.ncbi.nlm.nih.gov/34748727

المؤلفون: Ellie B. M. Landman, Razvan L Miclea, Clemens van Blitterswijk, Marcel Karperien

المساهمون: Faculty of Science and Technology, Developmental BioEngineering

المصدر: Arthritis Research & Therapy
Arthritis research & therapy, 15(4):R93. BioMed Central Ltd.

مصطلحات موضوعية: musculoskeletal diseases, Luciferase reporter construct, Immunology, Interleukin-1beta, Fluorescent Antibody Technique, Cartilage metabolism, Matrix metalloproteinase, Real-Time Polymerase Chain Reaction, Proinflammatory cytokine, WNT, Mice, Rheumatology, Downregulation and upregulation, Osteoarthritis, Gene expression, medicine, Immunology and Allergy, METIS-297333, Animals, Humans, skin and connective tissue diseases, Perylene, Wnt Signaling Pathway, Chemistry, Tumor Necrosis Factor-alpha, Cartilage, Arthritis, Wnt signaling pathway, Articular cartilage explants, IR-87043, Transcription factor TCF4, musculoskeletal system, Cartilage resorption, Cell biology, medicine.anatomical_structure, HEK293 Cells, Tumor necrosis factor alpha, Cartilage degradation, Transcriptome, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a142686fa0dc77b18665dde2f936efe
https://pubmed.ncbi.nlm.nih.gov/23965253

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المؤلفون: Sirp A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Roots K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Nurm K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia., Tuvikene J; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia., Sepp M; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia. Electronic address: m.sepp@zmbh.uni-heidelberg.de., Timmusk T; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Protobios LLC, Tallinn, Estonia. Electronic address: tonis.timmusk@taltech.ee.

المصدر: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101381. Date of Electronic Publication: 2021 Nov 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Facies* , Hyperventilation*/genetics , Hyperventilation*/metabolism , Intellectual Disability*/genetics , Intellectual Disability*/metabolism , Mutation, Missense* , Schizophrenia*/genetics , Schizophrenia*/metabolism , Transcription Factor 4*/chemistry , Transcription Factor 4*/genetics , Transcription Factor 4*/metabolism , Transcription, Genetic*, Amino Acid Substitution ; Animals ; HEK293 Cells ; Helix-Loop-Helix Motifs ; Humans ; Rats ; Rats, Sprague-Dawley

SCR Disease Name: Pitt-Hopkins syndrome