المؤلفون: Andersson-Assarsson, JC, van Deuren, RC, Kristensson, FM, Steehouwer, M, Sjoholm, K, Svensson, PA, Pieterse, M, Gilissen, C, Taube, M, Jacobson, P, Perkins, R, Brunner, HG, Netea, MG, Peltonen, M, Carlsson, B, Hoischen, A, Carlsson, LMS

المصدر: EBioMedicine. 92:104621

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:152919209

المؤلفون: Sikking MA; Department of Cardiology, Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands., Stroeks SLVM; Department of Cardiology, Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium., Henkens MTHM; Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands; Netherlands Heart Institute (NLHI), Utrecht, the Netherlands., Raafs AG; Department of Cardiology, Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands., Cossins B; Radboud University Medical Center, Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., van Deuren RC; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Steehouwer M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Riksen NP; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., van den Wijngaard A; Department of Clinical Genetics, Maastricht University, Maastricht, the Netherlands., Brunner HG; Department of Clinical Genetics, Maastricht University, Maastricht, the Netherlands; GROW Institute for Developmental Biology and Cancer, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Human Genetics and Donders Center for Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands., Hoischen A; Radboud University Medical Center, Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Verdonschot JAJ; Department of Cardiology, Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University, Maastricht, the Netherlands. Electronic address: job.verdonschot@mumc.nl., Heymans SRB; Department of Cardiology, Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium.

المصدر: JACC. Heart failure [JACC Heart Fail] 2024 May; Vol. 12 (5), pp. 905-914. Date of Electronic Publication: 2023 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomyopathy, Dilated*/genetics , Cardiomyopathy, Dilated*/physiopathology , Clonal Hematopoiesis*/genetics, Humans ; Female ; Male ; Middle Aged ; Prognosis ; Aged ; Mutation ; Gene Frequency ; Adult ; Age Factors

المؤلفون: Dregoesc MI; 'Iuliu Hatieganu' University of Medicine and Pharmacy, Department of Cardiology -'Niculae Stăncioiu' Heart Institute, 19-21 Calea Moților, 400001 Cluj-Napoca, Romania., Tercan H; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands., Țigu AB; MEDFUTURE Research Center for Advanced Medicine, Department of Translational Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 4-6 Louis Pasteur, 400349 Cluj-Napoca, Romania., Bekkering S; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands., Joosten LA; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, 4-6 Louis Pasteur, 400349 Cluj-Napoca, Romania., Netea MG; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany., van Deuren RC; Radboud University Medical Center, Department of Human Genetics, Geert Grooteplein Zuid 855, 6525 GA Nijmegen, the Netherlands., Hoischen A; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands.; Radboud University Medical Center, Department of Human Genetics, Geert Grooteplein Zuid 855, 6525 GA Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, the Netherlands., Riksen NP; Radboud University Medical Center, Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, the Netherlands., Iancu AC; 'Iuliu Hatieganu' University of Medicine and Pharmacy, Department of Cardiology -'Niculae Stăncioiu' Heart Institute, 19-21 Calea Moților, 400001 Cluj-Napoca, Romania.

المصدر: IScience [iScience] 2024 Mar 11; Vol. 27 (4), pp. 109472. Date of Electronic Publication: 2024 Mar 11 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Tercan H; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands., Cossins BC; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands., van Deuren RC; Radboud University Medical Center Department of Human Genetics Nijmegen the Netherlands., Rutten JHW; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands., Joosten LAB; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands.; Department of Medical Genetics Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca Romania., Netea MG; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands.; Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES) University of Bonn Germany., Hoischen A; Radboud University Medical Center Department of Human Genetics Nijmegen the Netherlands., Bekkering S; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands., Riksen NP; Radboud University Medical Center Department of Internal Medicine Nijmegen the Netherlands.

المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2024 Jan 16; Vol. 13 (2), pp. e031665. Date of Electronic Publication: 2024 Jan 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

مواضيع طبية MeSH: Metabolic Syndrome*/complications , Metabolic Syndrome*/genetics , Atherosclerosis*/metabolism, Male ; Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Clonal Hematopoiesis ; Leukocytes, Mononuclear/metabolism ; Cross-Sectional Studies ; Overweight/metabolism ; Hematopoiesis/genetics ; Obesity/complications ; Obesity/genetics ; Inflammation/metabolism ; Interleukin-6/metabolism ; Mutation

المؤلفون: Rops MAJ; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Moorlag SJCFM; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., van Deuren RC; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Jaeger M; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Joosten LAB; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Medici M; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Smit JWA; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Netea-Maier RT; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands, romana.netea-maier@radboudumc.nl.

المصدر: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2022 Sept 08; Vol. 66 (4), pp. 472-480. Date of Electronic Publication: 2022 Jun 02.

نوع المنشور: Journal Article; Observational Study

بيانات الدورية: Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*/epidemiology , Thyroid Diseases*/complications , Thyroid Diseases*/epidemiology, Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Self Report

المؤلفون: van der Heijden WA; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van Deuren RC; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van de Wijer L; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van den Munckhof ICL; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Steehouwer M; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Riksen NP; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Netea MG; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department for Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., de Mast Q; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium., de Voer RM; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van der Ven AJ; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Hoischen A; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.

المصدر: The Journal of infectious diseases [J Infect Dis] 2022 Apr 19; Vol. 225 (8), pp. 1339-1347.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Cardiovascular Diseases*/complications , HIV Infections*/complications , Neoplasms*/complications, Clonal Hematopoiesis ; Cross-Sectional Studies ; Disease Progression ; Humans ; Mutation

المؤلفون: Svensson E; Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden., Günther T; Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden. Electronic address: torsten.guenther@ebc.uu.se., Hoischen A; Department of Human Genetics, Radboud University Medical Center, 6526 Nijmegen, the Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6526 Nijmegen, the Netherlands., Hervella M; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), B° Sarriena s/n 48940 Leioa, Bizkaia, Spain., Munters AR; Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden., Ioana M; Laboratory of Human Genetics, University of Medicine and Pharmacy, Craiova, Romania., Ridiche F; Oltenia Museum Craiova, Craiova, Romania., Edlund H; Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden., van Deuren RC; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6526 Nijmegen, the Netherlands., Soficaru A; 'Francisc J. Rainer' Institute of Anthropology, Romanian Academy, 050474 Bucharest, Romania., de-la-Rua C; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), B° Sarriena s/n 48940 Leioa, Bizkaia, Spain., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6526 Nijmegen, the Netherlands; Laboratory of Human Genetics, University of Medicine and Pharmacy, Craiova, Romania., Jakobsson M; Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden. Electronic address: mattias.jakobsson@ebc.uu.se.

المصدر: Current biology : CB [Curr Biol] 2021 Jul 26; Vol. 31 (14), pp. 2973-2983.e9. Date of Electronic Publication: 2021 May 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE

مواضيع طبية MeSH: Neanderthals*/genetics, Animals ; Emigration and Immigration ; Europe ; Female ; Genome, Human ; Humans ; Infant, Newborn ; Skull

المؤلفون: van Deuren RC; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands., Arts P; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia., Cavalli G; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.; Department of Medicine, University of Colorado, Aurora, CO, USA., Jaeger M; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands., Steehouwer M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van de Vorst M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Gilissen C; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands., Joosten LAB; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Dinarello CA; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medicine, University of Colorado, Aurora, CO, USA., Mhlanga MM; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands.; Epigenomics & Single Cell Biophysics Group, Department of Cell Biology, Radboud University, 6525 GA, Nijmegen, The Netherlands., Kumar V; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Medical Sciences Complex, Deralakatte, Mangalore, 575018, India., Netea MG; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany., van de Veerdonk FL; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands., Hoischen A; Department of Internal Medicine, Radboud Expertise Center for Immunodeficiency and Autoinflammation, and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Alexander.Hoischen@radboudumc.nl.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. Alexander.Hoischen@radboudumc.nl.; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, the Netherlands. Alexander.Hoischen@radboudumc.nl.

المصدر: Genome medicine [Genome Med] 2021 May 25; Vol. 13 (1), pp. 94. Date of Electronic Publication: 2021 May 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Genetic Variation* , Signal Transduction*, Cytokines/*genetics , Interleukin-1/*genetics , Interleukin-1/*metabolism, Biomarkers ; Cytokines/metabolism ; Disease Susceptibility ; Gene Expression Profiling ; Healthy Volunteers ; High-Throughput Nucleotide Sequencing ; Humans ; Immunity, Innate ; Immunophenotyping ; Inflammation/genetics ; Inflammation/metabolism ; Interleukin-1beta ; Systems Biology/methods

المؤلفون: Moorlag SJCFM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., van Deuren RC; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van Werkhoven CH; The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Jaeger M; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Debisarun P; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Taks E; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Mourits VP; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Koeken VACM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., de Bree LCJ; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Danish Institute for Advanced Study, University of Southern Denmark, Denmark.; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark., Ten Doesschate T; The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Cleophas MC; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Smeekens S; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Oosting M; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Joosten LAB; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Ten Oever J; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., van der Meer JWM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Curtis N; Department of Paediatrics, The University of Melbourne; and Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia., Aaby P; Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau., Stabell-Benn C; Danish Institute for Advanced Study, University of Southern Denmark, Denmark.; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark., Giamarellos-Bourboulis EJ; 4 Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.; 4 Department of Internal Medicine, ATTIKON University Hospital, Athens, Greece., Bonten M; Department of Medical Microbiology, The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Crevel R; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.

المصدر: Cell reports. Medicine [Cell Rep Med] 2020 Aug 25; Vol. 1 (5), pp. 100073. Date of Electronic Publication: 2020 Aug 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med

مواضيع طبية MeSH: BCG Vaccine/*administration & dosage , COVID-19/*epidemiology , Vaccination/*statistics & numerical data, Adult ; Aged ; BCG Vaccine/immunology ; COVID-19/immunology ; Female ; Humans ; Immunologic Memory ; Incidence ; Male ; Middle Aged ; Netherlands/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult

المؤلفون: van der Made CI; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Simons A; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Schuurs-Hoeijmakers J; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van den Heuvel G; Pulmonology Department, Radboud University Medical Center, Nijmegen, the Netherlands., Mantere T; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Kersten S; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van Deuren RC; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Steehouwer M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van Reijmersdal SV; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Jaeger M; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Hofste T; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Astuti G; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Corominas Galbany J; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van der Schoot V; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., van der Hoeven H; Department of Intensive Care, Radboud University Medical Center Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Hagmolen Of Ten Have W; Pulmonology Department, Radboud University Medical Center, Nijmegen, the Netherlands., Klijn E; Department of Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands., van den Meer C; Department of Intensive Care, Ziekenhuis Rivierenland, Tiel, the Netherlands., Fiddelaers J; Department of Pulmonology, Admiraal de Ruyter Ziekenhuis, Goes, the Netherlands., de Mast Q; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Bleeker-Rovers CP; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Joosten LAB; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Yntema HG; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Gilissen C; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Nelen M; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., van der Meer JWM; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Brunner HG; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; GROW School of Oncology and developmental biology, and MHeNs School of Mental Health and Neuroscience, Maastricht University, the Netherlands., Netea MG; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany., van de Veerdonk FL; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Hoischen A; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud University Medical Center Center for Infectious Diseases (RCI), Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

المصدر: JAMA [JAMA] 2020 Aug 18; Vol. 324 (7), pp. 663-673.

نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

مواضيع طبية MeSH: Loss of Function Mutation*, COVID-19/*virology , SARS-CoV-2/*genetics, Adult ; Enzyme-Linked Immunosorbent Assay ; Fatal Outcome ; Hospitalization ; Humans ; Intensive Care Units ; Leukocytes, Mononuclear ; Male ; Netherlands ; Pedigree ; RNA, Viral/analysis ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; Young Adult