المؤلفون: Choi J; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Gang S; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea.; Department of Pre-Medical Science, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Ramalingam M; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Hwang J; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Jeong H; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Yoo J; Department of Physiological Education, Chonnam National University, Gwangju, 61186, Republic of Korea., Cho HH; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea., Kim BC; Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea., Jang G; School of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea., Jeong HS; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea. jhsjeong@hanmail.net., Jang S; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea. sujeong.jjang@gmail.com.

المصدر: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Sep; Vol. 479 (9), pp. 2391-2403. Date of Electronic Publication: 2023 Sep 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*/drug effects , Wnt Signaling Pathway*/drug effects , Neurons*/metabolism , Neurons*/drug effects , Neurons*/cytology, Humans ; Cell Line, Tumor ; Calcium/metabolism

المؤلفون: Zhang Y; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China., Xu J; Neurosurgery of the Third People's Hospital of Mianyang/Sichuan Mental Health Center, Mianyang, 621000, Sichuan, China., Li P; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China., Luo B; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China., Tang H; Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China. Electronic address: hweitang@gmail.com.

المصدر: Experimental neurology [Exp Neurol] 2024 Jul; Vol. 377, pp. 114782. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/pathology , Blood-Brain Barrier*/drug effects , Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/pathology , Mice, Inbred C57BL* , Wnt Signaling Pathway*/drug effects , Wnt Signaling Pathway*/physiology , Transcytosis*/drug effects , Transcytosis*/physiology , Caveolin 1*/metabolism, Animals ; Mice ; Male ; Symporters

المؤلفون: Hua X; Department of Neurosurgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China., Zhao C; Department of Neurosurgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China., Tian J; Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, China.; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Wang J; Department of Neurosurgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China., Miao X; Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, China.; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Zheng G; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wu M; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China.; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.; College of Life Sciences, Wuhan University, Wuhan, China., Ye M; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China., Liu Y; Department of Neurosurgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China., Zhou Y; Department of Neurosurgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.; Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, China.

المصدر: ELife [Elife] 2024 Sep 25; Vol. 13. Date of Electronic Publication: 2024 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: beta Catenin*/metabolism , beta Catenin*/genetics , Homeostasis* , Intestinal Mucosa*/metabolism , Wnt Signaling Pathway*, Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Enhancer Elements, Genetic/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Transcription, Genetic

المؤلفون: Ding D; Department of Neurosurgery, Tianjin Huanhu Hospital., Gao K; Department of Neurosurgery, Tianjin Huanhu Hospital., Zhang X; Department of Pathology, Tianjin Huanhu Hospital., Wang H; Department of Neurosurgery, Tianjin Huanhu Hospital.; Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative diseases, Tianjin Neurosurgical Institute.

المصدر: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2024 Sep 18; Vol. 263 (3), pp. 199-210. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3329 (Electronic) Linking ISSN: 00408727 NLM ISO Abbreviation: Tohoku J Exp Med Subsets: MEDLINE

مواضيع طبية MeSH: Arsenic Trioxide*/pharmacology , Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/drug therapy , Wnt Signaling Pathway*/drug effects , Arsenicals*/pharmacology , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , beta Catenin*/metabolism, Animals ; Humans ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/drug effects ; Oxides/pharmacology ; Cell Proliferation/drug effects ; Mice ; Xenograft Model Antitumor Assays ; Brain Neoplasms/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/drug therapy ; Gene Expression Regulation, Neoplastic/drug effects ; Mice, Nude

المؤلفون: Boonsawat P; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Asadollahi R; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland; Faculty of Engineering and Science, University of Greenwich London, Medway Campus, Chatham Maritime ME4 4TB, UK., Niedrist D; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Steindl K; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Begemann A; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Joset P; Medical Genetics, University Hospital Basel, Basel, Switzerland., Bhoj EJ; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Li D; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zackai E; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Vetro A; Neuroscience Department, Meyer Children's Hospital IRCCS, Florence, Italy., Barba C; Neuroscience Department, Meyer Children's Hospital IRCCS, Florence, Italy; University of Florence, Florence, Italy., Guerrini R; Neuroscience Department, Meyer Children's Hospital IRCCS, Florence, Italy., Whalen S; Unité Fonctionnelle de Génétique Odellin, Hôpital Armand Trousseau, Paris, France., Keren B; Département de Génétique, Hôpital de la Pitié-Salpêtrière, Paris, France., Khan A; Faculty of Science, Department of Biological Science (Zoology), University of Lakki Marwat, Khyber Pakhtunkhwa 28420, Pakistan., Jing D; Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Palomares Bralo M; Instituto de Genética Médica y Molecular (INGEMM), Unidad de Trastornos Del Neurodesarrollo, Hospital Universitario La Paz, Madrid, Spain., Rikeros Orozco E; Instituto de Genética Médica y Molecular (INGEMM), Unidad de Trastornos Del Neurodesarrollo, Hospital Universitario La Paz, Madrid, Spain., Hao Q; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Schlott Kristiansen B; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Zheng B; Nanjing Key Laboratory of Pediatrics Children's Hospital of Nanjing Medical University, Nanjing, China., Donnelly D; Northern Ireland Regional Genetics Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland., Clowes V; Thames Regional Genetics Service, North West University Healthcare NHS Trust, London, UK., Zweier M; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Papik M; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Siegel G; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Sabatino V; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Mocera M; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland., Horn AHC; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Sticht H; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Rauch A; Institute of Medical Genetics, University of Zurich, Zurich, Switzerland; Pediatric University Hospital Zurich, Zurich, Switzerland. Electronic address: anita.rauch@medgen.uzh.ch.

المصدر: American journal of human genetics [Am J Hum Genet] 2024 Sep 05; Vol. 111 (9), pp. 1994-2011. Date of Electronic Publication: 2024 Aug 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Wnt Signaling Pathway*/genetics , Germ-Line Mutation* , Neurodevelopmental Disorders*/genetics , Neurodevelopmental Disorders*/pathology , Phenotype* , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Brain*/metabolism , Brain*/pathology, Humans ; Female ; Male ; Child ; Child, Preschool ; beta Catenin/genetics ; beta Catenin/metabolism ; Adolescent ; Mutation, Missense ; Genetic Association Studies ; Protein Domains

المؤلفون: Ke J; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.; Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Gaozhou, China., Chen G; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., You Y; Maoming Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Maoming, China., Xie Q; Animal Experiment Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Liu ZL; The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China., Song C; Guangzhou International Bio Island, Guangzhou, China., Zheng Y; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Shan Z; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China., Song J; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Jiang Z; International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China., Wang H; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China., Du Q; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Wu Y; Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Gaozhou, China., Chen XL; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China., Li Y; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.

المصدر: Cancer medicine [Cancer Med] 2024 Sep; Vol. 13 (18), pp. e70245.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

مواضيع طبية MeSH: Wnt Signaling Pathway* , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology , Tumor Microenvironment*/immunology , CD11b Antigen*/metabolism , B7-2 Antigen*/metabolism , AC133 Antigen*/metabolism, Animals ; Humans ; Mice ; Male ; Female ; HCT116 Cells ; Disease Models, Animal ; Organoids/metabolism ; THP-1 Cells ; Prognosis

المؤلفون: Tiwari P; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mueed S; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P., India., Abdulkareem AO; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria., Hanif K; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: k_hanif@cdri.res.in.

المصدر: Molecular and cellular neurosciences [Mol Cell Neurosci] 2024 Sep; Vol. 130, pp. 103953. Date of Electronic Publication: 2024 Jul 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9327 (Electronic) Linking ISSN: 10447431 NLM ISO Abbreviation: Mol Cell Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin-Converting Enzyme 2*/metabolism , Neurogenesis*/drug effects , Hippocampus*/metabolism , Hypertension*/metabolism , Wnt Signaling Pathway*/drug effects , Wnt Signaling Pathway*/physiology, Animals ; Rats ; Male ; Diminazene/analogs & derivatives ; Diminazene/pharmacology ; Peptidyl-Dipeptidase A/metabolism ; Rats, Sprague-Dawley

المؤلفون: Fan Z; The department of Orthopedics, Tianjin Hospital, Tianjin, 300070, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, Tianjin, 300050, China., Zhao X; The department of Orthopedics, Tianjin Hospital, Tianjin, 300070, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, Tianjin, 300050, China., Ma J; The department of Orthopedics, Tianjin Hospital, Tianjin, 300070, People's Republic of China. 517494450@qq.com.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, Tianjin, 300050, China. 517494450@qq.com., Zhan H; The department of Orthopedics, Tianjin Hospital, Tianjin, 300070, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, Tianjin, 300050, China., Ma X; The department of Orthopedics, Tianjin Hospital, Tianjin, 300070, People's Republic of China. maxinlong23@outlook.com.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, Tianjin, 300050, China. maxinlong23@outlook.com.

المصدر: Calcified tissue international [Calcif Tissue Int] 2024 Sep; Vol. 115 (3), pp. 283-297. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE

مواضيع طبية MeSH: Wnt Signaling Pathway*/physiology , Wnt Signaling Pathway*/drug effects , Osteoarthritis*/metabolism , YAP-Signaling Proteins*/metabolism , Cartilage, Articular*/metabolism , Cartilage, Articular*/pathology , Rats, Sprague-Dawley*, Animals ; Rats ; Male ; Chondrocytes/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; beta Catenin/metabolism ; Ankle Joint/pathology

المؤلفون: Sanchez-Ruiz JA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, Mexico., Treviño-Alvarez AM; Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, Mexico., Zambrano-Lucio M; KER Unit Mexico, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico., Lozano Díaz ST; Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey, San Pedro Garza Garcia, Nuevo Leon, Mexico., Wang N; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Biernacka JM; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Tye SJ; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA., Cuellar-Barboza AB; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address: alfredo.cuellarb@uanl.mx.

المصدر: Psychiatry research [Psychiatry Res] 2024 Sep; Vol. 339, pp. 115983. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article; Systematic Review; Review

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE

مواضيع طبية MeSH: Depressive Disorder, Major*/metabolism , Wnt Signaling Pathway*/physiology, Humans

المؤلفون: Jin X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, Zhejiang 310058, PR China; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, Zhejiang 310018, PR China., Wang S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China., Luo L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address: luolihua@zju.edu.cn., Yan F; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, Zhejiang 310058, PR China; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, Zhejiang 310018, PR China. Electronic address: 11719047@zju.edu.cn., He Q; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address: qiaojunhe@zju.edu.cn.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Sep; Vol. 227, pp. 116463. Date of Electronic Publication: 2024 Aug 03.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Neoplasms*/drug therapy , Gastrointestinal Neoplasms*/metabolism , Wnt Signaling Pathway*/drug effects , Wnt Signaling Pathway*/physiology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Animals ; beta Catenin/metabolism ; beta Catenin/antagonists & inhibitors ; beta Catenin/genetics ; Molecular Targeted Therapy/methods