دورية أكاديمية
Protective effect of a thermoreversible gel against the toxicity of nonoxynol-9.
| العنوان: | Protective effect of a thermoreversible gel against the toxicity of nonoxynol-9. |
|---|---|
| المؤلفون: | Gagné N; Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Ste-Foy, Canada., Cormier H, Omar RF, Désormeaux A, Gourde P, Tremblay MJ, Juhász J, Beauchamp D, Rioux JE, Bergeron MG |
| المصدر: | Sexually transmitted diseases [Sex Transm Dis] 1999 Mar; Vol. 26 (3), pp. 177-83. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: J B Lippincott Country of Publication: United States NLM ID: 7705941 Publication Model: Print Cited Medium: Print ISSN: 0148-5717 (Print) Linking ISSN: 01485717 NLM ISO Abbreviation: Sex Transm Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : J B Lippincott Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Gels* , Polymers* , Protective Agents*, Nonoxynol/*toxicity, Animals ; Diffusion ; Drug Interactions ; Female ; Mucous Membrane/drug effects ; Polyethylene Glycols ; Polypropylenes ; Rabbits ; Tumor Cells, Cultured |
| مستخلص: | Background and Objectives: One major problem associated with the use of nonoxynol-9 is that it can induce local inflammation and ulceration of the vaginal and cervical mucosa that might favor the entry of pathogens. With the aim of developing a gel formulation that could be effective in preventing sexually transmitted infections, the authors have evaluated the capacity of a polyoxypropylene/polyoxyethylene polymer to reduce or eliminate the toxicity of nonoxynol-9. Study Design: The cytotoxicity of nonoxynol-9 alone or incorporated into the gel was investigated in human cervical and colon epithelial cells and after daily intravaginal application for 2 weeks in rabbits. Results: In vitro experiments showed that nonoxynol-9 was highly toxic to human cervical and colon epithelial cells in a dose-dependent manner. However, the incorporation of the spermicide into the gel markedly reduced its toxicity under the same experimental conditions. In vivo studies showed that in animals treated with nonoxynol-9, the spermicide was very toxic to the vaginal and cervical mucosa as evidenced by the presence of bleeding, irritation, epithelial disruption, necrosis, the accumulation of leukocytes in the submucosa, and the loss of integrity of the epithelial cells. Of prime importance, the incorporation of nonoxynol-9 into the gel markedly reduced the toxicity of this potent spermicide/microbicide. Conclusion: The gel formulation could be used as an interesting approach to eliminate the toxicity of potent spermicides/microbicides such as nonoxynol-9. |
| المشرفين على المادة: | 0 (Gels) 0 (Polymers) 0 (Polypropylenes) 0 (Protective Agents) 26027-38-3 (Nonoxynol) 3WJQ0SDW1A (Polyethylene Glycols) |
| تواريخ الأحداث: | Date Created: 19990401 Date Completed: 19990610 Latest Revision: 20190909 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1097/00007435-199903000-00009 |
| PMID: | 10100776 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0148-5717 |
|---|---|
| DOI: | 10.1097/00007435-199903000-00009 |