دورية أكاديمية
Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis.
| العنوان: | Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis. |
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| المؤلفون: | Marley R; Department of Medicine, The Royal Free and University College Medical School, London, UK., Holt S, Fernando B, Harry D, Anand R, Goodier D, Davies S, Moore K |
| المصدر: | Hepatology (Baltimore, Md.) [Hepatology] 1999 May; Vol. 29 (5), pp. 1358-63. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Print ISSN: 0270-9139 (Print) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc. Original Publication: Baltimore, MD : Williams & Wilkins, [c1981]- |
| مواضيع طبية MeSH: | Blood Circulation/*drug effects , Cardiovascular Diseases/*prevention & control , Liver Cirrhosis, Biliary/*drug therapy , Thioctic Acid/*therapeutic use, Animals ; Glutathione/metabolism ; Hemodynamics/drug effects ; Lipid Peroxides/blood ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis, Biliary/metabolism ; Liver Cirrhosis, Biliary/pathology ; Liver Cirrhosis, Biliary/physiopathology ; Male ; Nitrates/blood ; Nitric Oxide Synthase/metabolism ; Nitrites/blood ; Rats ; Rats, Sprague-Dawley ; Reference Values |
| مستخلص: | Chronic bile duct ligation is associated with the development of oxidant injury, biliary cirrhosis, portal hypertension, and a hyperdynamic circulation. We have previously demonstrated that the hyperdynamic circulation in the partial portal vein-ligated rat can be prevented by the administration of N-acetylcysteine. To extend these findings, we have examined the effect of lipoic acid, a thiol-containing antioxidant, on hemodynamics, oxidative stress, and nitric oxide (NO) production in bile duct-ligated (BDL) cirrhotic rats. Lipoic acid was given continuously in drinking water to normal and BDL rats; control rats received ordinary drinking water, and animals were studied at 24 days following surgery. Lipoic acid prevented the development of the hyperdynamic circulation (cardiac index [CI]: 15.7 +/- 2.0 vs. 29.5 +/- 2.1 mL x min-1 x 100 g-1; P <. 05) and significantly attenuated the rise in portal pressure (PP) (12.7 +/- 0.8 vs. 15.2 +/- 0.5 mm Hg; P <.05). Hepatic nitric oxide synthase (NOS) activity and plasma nitrite/nitrate concentration increased significantly following bile duct ligation, and both of these were prevented by lipoic acid. Lipoic acid had no effect on the biochemical or histological parameters of liver function in the cirrhotic group. We conclude that lipoic acid prevents the development of the hyperdynamic circulation in the rat model of biliary cirrhosis, and that this is associated with decreased synthesis of NO. |
| المشرفين على المادة: | 0 (Lipid Peroxides) 0 (Nitrates) 0 (Nitrites) 73Y7P0K73Y (Thioctic Acid) EC 1.14.13.39 (Nitric Oxide Synthase) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 19990427 Date Completed: 19990519 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1002/hep.510290519 |
| PMID: | 10216116 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0270-9139 |
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| DOI: | 10.1002/hep.510290519 |