دورية أكاديمية
[Cerebral hemodynamics and metabolism in the acute stage of cerebral aneurysm rupture].
العنوان: | [Cerebral hemodynamics and metabolism in the acute stage of cerebral aneurysm rupture]. |
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عنوان ترانسليتريتد: | Tserebral'naia gemodinamika i metabolizm v ostroĭ stadii razryva anevrizm golovnogo mozga. |
المؤلفون: | Promyslov MSh, Shakhnovich AR, Amcheslavskiĭ VG, Aref'eva IA, Dausheva AA, Belousova OB, Demchuk ML, Miakota AE, Oganesian KG |
المصدر: | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 1999 Jan-Mar (1), pp. 11-4; discussion 14-5. |
نوع المنشور: | English Abstract; Journal Article |
اللغة: | Russian |
بيانات الدورية: | Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 7809757 Publication Model: Print Cited Medium: Print ISSN: 0042-8817 (Print) Linking ISSN: 00428817 NLM ISO Abbreviation: Zh Vopr Neirokhir Im N N Burdenko Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Moskva : Media Sfera Original Publication: Moskva, Meditsina. |
مواضيع طبية MeSH: | Aneurysm, Ruptured/*physiopathology , Brain/*physiopathology , Intracranial Aneurysm/*physiopathology, Acute Disease ; Aneurysm, Ruptured/cerebrospinal fluid ; Aneurysm, Ruptured/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Energy Metabolism/drug effects ; Free Radicals/metabolism ; Hemodynamics/drug effects ; Humans ; Intracranial Aneurysm/cerebrospinal fluid ; Intracranial Aneurysm/drug therapy ; Lipid Peroxidation/drug effects ; Luminescent Measurements ; Nimodipine/pharmacology ; Nimodipine/therapeutic use ; Vasodilator Agents/pharmacology ; Vasodilator Agents/therapeutic use |
مستخلص: | The relationship between lipid peroxidation products and the severity of arterial spasm was studied in 86 patients. For this, the level of radical production, the content of the end lipid peroxidation product malonic dialdehyde and the overall antioxidative activity of lumbar cerebrospinal fluid were determined during 24-hour Doppler monitoring of blood flow in the middle cerebral and internal carotid arteries. Following subarachnoidal hemorrhage, the activation of lipid peroxidation processes was shown to correlate with the severity of arterial spasm and it is likely to contribute to the development of late ischemias. Nimotop used to treat patients with significant arterial spasm caused a reduction in the rate of free radical lipid peroxidation to that characteristic for patients with moderate spasm. The findings suggest that it is expedient of including antioxidants into the combined therapy of patients with acute subarachnoidal hemorrhage. |
المشرفين على المادة: | 0 (Antioxidants) 0 (Free Radicals) 0 (Vasodilator Agents) 57WA9QZ5WH (Nimodipine) |
تواريخ الأحداث: | Date Created: 19990521 Date Completed: 19990616 Latest Revision: 20131121 |
رمز التحديث: | 20231215 |
PMID: | 10335570 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0042-8817 |
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