دورية أكاديمية
Clinical and molecular followup after radical retropubic prostatectomy.
| العنوان: | Clinical and molecular followup after radical retropubic prostatectomy. |
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| المؤلفون: | Oefelein MG; Department of Urology, Evanston Hospital/Northwestern University Medical School, Illinois 60201, USA., Ignatoff JM, Clemens JQ, Watkin W, Kaul KL |
| المصدر: | The Journal of urology [J Urol] 1999 Aug; Vol. 162 (2), pp. 307-10; discussion 310-1. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0376374 Publication Model: Print Cited Medium: Print ISSN: 0022-5347 (Print) Linking ISSN: 00225347 NLM ISO Abbreviation: J Urol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : [Philadelphia, PA] : Wolters Kluwer Original Publication: Baltimore : Lippincott Williams & Wilkins |
| مواضيع طبية MeSH: | Neoplastic Cells, Circulating* , Prostatectomy*, Adenocarcinoma/*blood , Adenocarcinoma/*surgery , Prostate-Specific Antigen/*blood , Prostatic Neoplasms/*blood , Prostatic Neoplasms/*surgery, Adenocarcinoma/pathology ; Adult ; Aged ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Prostatic Neoplasms/pathology ; Reverse Transcriptase Polymerase Chain Reaction |
| مستخلص: | Purpose: We previously reported evidence of hematogenous dissemination of prostate cells during radical retropubic prostatectomy, and we now provide clinical and molecular reverse transcriptase-polymerase chain reaction (RT-PCR) followup of that patient cohort. Materials and Methods: A total of 101 men with clinically localized prostate cancer were prospectively enrolled in the study. The prostate specific antigen (PSA) RT-PCR assay was performed on peripheral venous blood samples preoperatively in 101, during surgery in 29, during and up to 12 weeks after surgery in 50 and at least 1 year postoperatively in 65 patients. Correlation with clinical (PSA) indicators of recurrence was performed. Results: Of the 101 patients 9 demonstrated biochemical evidence of prostate cancer progression (median followup 22 months). Of the 50 men with perioperative molecular results the RT-PCR positive rate increased from 22% preoperatively in 11 to 48% in 24 (p = 0.02) and then decreased to 10% in 4 of 40 men at 1 year postoperatively (p = 0.07). Molecular followup at a minimum of 1 year after radical retropubic prostatectomy was obtained in 65 men, of whom the RT-PCR positive rate decreased from 23% preoperatively in 14 to 9.2% in 6 (p = 0.05). No significant correlation was observed between a persistently positive RT-PCR result and biochemical failure. Conclusions: Although a significant proportion of men have molecular evidence of hematogenous prostate cell dissemination intraoperatively, longitudinal molecular and clinical followup demonstrates reconversion to a negative status as the predominant trend. At relatively short followup no significant correlation was identified between the RT-PCR result and the PSA progression-free survival. |
| المشرفين على المادة: | EC 3.4.21.77 (Prostate-Specific Antigen) |
| تواريخ الأحداث: | Date Created: 19990720 Date Completed: 19990817 Latest Revision: 20220317 |
| رمز التحديث: | 20221213 |
| PMID: | 10411026 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-5347 |
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