دورية أكاديمية
Peripheral markers of oxidative stress in probable Alzheimer patients.
| العنوان: | Peripheral markers of oxidative stress in probable Alzheimer patients. |
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| المؤلفون: | Repetto MG; Catedra de Quimica General e Inorganica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina. mrepetto@huemul.ffyb.uba.ar, Reides CG, Evelson P, Kohan S, de Lustig ES, Llesuy SF |
| المصدر: | European journal of clinical investigation [Eur J Clin Invest] 1999 Jul; Vol. 29 (7), pp. 643-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print Cited Medium: Print ISSN: 0014-2972 (Print) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation. |
| مواضيع طبية MeSH: | Oxidative Stress*, Alzheimer Disease/*blood , Antioxidants/*analysis , Catalase/*blood , Erythrocytes/*physiology, Aged ; Alzheimer Disease/psychology ; Antioxidants/metabolism ; Biomarkers/blood ; Erythrocytes/drug effects ; Female ; Hemoglobins/analysis ; Humans ; Luminescent Measurements ; Male ; Reference Values ; tert-Butylhydroperoxide/pharmacology |
| مستخلص: | Background: The current research on Alzheimer's disease is mainly focused in the post-mortem characterization of pathological and biochemical alterations in the brain. The finding of peripheral markers that could be associated with the changes observed in the Alzheimer's brain would be of interest in this field. The aim of the present study was to evaluate the state of different peripheral markers of oxidative stress in probable Alzheimer patients and compare them with a group of healthy individuals. Design: The determinations made include the plasma total antioxidant capacity (TRAP) and tert-butyl hydroperoxide-initiated chemiluminescence and catalase activity in erythrocytes from 18 patients with probable Alzheimer's disease and 18 matched control subjects with normal cognitive function. Results: TRAP was decreased in Alzheimer patients by 24% (control group 308 micromol L-1 Trolox, SEM 34, n = 18). tert-Butyl hydroperoxide-initiated chemiluminescence and catalase activity showed an increase in erythrocytes from Alzheimer patients by 52% (control group 116 700 cps mg-1 haemoglobin, SEM 6690) and 75% (control group 2.55 pmol mg-1 protein, SEM 0.39, n = 18) respectively. Conclusion: Oxidative stress in the blood of probable Alzheimer patients could be a reflection of the brain condition and suggests that oxygen free radicals could be partially responsible of the damage observed in this disease. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Biomarkers) 0 (Hemoglobins) 955VYL842B (tert-Butylhydroperoxide) EC 1.11.1.6 (Catalase) |
| تواريخ الأحداث: | Date Created: 19990720 Date Completed: 19990816 Latest Revision: 20190826 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1046/j.1365-2362.1999.00506.x |
| PMID: | 10411672 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-2972 |
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| DOI: | 10.1046/j.1365-2362.1999.00506.x |