دورية أكاديمية
[Averaging results of site recognition can increase the accuracy of annotating the human genome].
| العنوان: | [Averaging results of site recognition can increase the accuracy of annotating the human genome]. |
|---|---|
| عنوان ترانسليتريتد: | Usrednenie rezul'tatov raspoznavaniia saĭtov mozhet uvelichit' tochnost' annotatsii genoma cheloveka. |
| المؤلفون: | Ponomarenko MP; Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia., Ponomarenko IuV, Podkolodnaia OA, Frolov AS, Vorob'ev DV, Kolchanov NA, Overton GC |
| المصدر: | Biofizika [Biofizika] 1999 Jul-Aug; Vol. 44 (4), pp. 649-54. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0372666 Publication Model: Print Cited Medium: Print ISSN: 0006-3029 (Print) Linking ISSN: 00063029 NLM ISO Abbreviation: Biofizika Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Genome, Human*, DNA/*metabolism, Base Sequence ; Binding Sites ; CCAAT-Enhancer-Binding Proteins ; DNA/genetics ; DNA-Binding Proteins/metabolism ; Erythroid-Specific DNA-Binding Factors ; GATA1 Transcription Factor ; Humans ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism |
| مستخلص: | A systemic approach is proposed, which makes it possible to increase the accuracy of recognition of functional sites in arbitrary DNA sequences. The approach is based on the Central limit theorem and consists in the averaging of a large number of recognitions of a particular site. To obtain a rather large number of recognitions within the framework of conventional methods of recognition, consensus, and frequency matrix, 20 novel oligonucleotide alphabets were used. The approach was used to study the binding sites of GATA-1 and C/EBP transcription factors. It was found that the averaged recognition of these sites is more precise than each of specific recognitions, which just follows from the Central limit theorem. |
| المشرفين على المادة: | 0 (CCAAT-Enhancer-Binding Proteins) 0 (DNA-Binding Proteins) 0 (Erythroid-Specific DNA-Binding Factors) 0 (GATA1 Transcription Factor) 0 (GATA1 protein, human) 0 (Nuclear Proteins) 0 (Transcription Factors) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 19991102 Date Completed: 19991206 Latest Revision: 20061115 |
| رمز التحديث: | 20221213 |
| PMID: | 10544815 |
| قاعدة البيانات: | MEDLINE |
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