دورية أكاديمية
Effectiveness of the angiogenesis inhibitor TNP-470 in reducing the growth of human neuroblastoma in nude mice inversely correlates with tumor burden.
| العنوان: | Effectiveness of the angiogenesis inhibitor TNP-470 in reducing the growth of human neuroblastoma in nude mice inversely correlates with tumor burden. |
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| المؤلفون: | Katzenstein HM; Department of Pediatrics, Children's Memorial Hospital, Chicago, Illinois 60614, USA., Rademaker AW, Senger C, Salwen HR, Nguyen NN, Thorner PS, Litsas L, Cohn SL |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 1999 Dec; Vol. 5 (12), pp. 4273-8. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Print ISSN: 1078-0432 (Print) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | Angiogenesis Inhibitors/*pharmacology , Antibiotics, Antineoplastic/*pharmacology , Growth Inhibitors/*pharmacology , Neuroblastoma/*pathology , Sesquiterpenes/*pharmacology, Animals ; Cell Division/drug effects ; Cyclohexanes ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Staging ; Neoplasm Transplantation ; Neovascularization, Pathologic ; Neuroblastoma/blood supply ; Neuroblastoma/drug therapy ; O-(Chloroacetylcarbamoyl)fumagillol ; Transplantation, Heterologous ; Tumor Cells, Cultured |
| مستخلص: | Angiogenesis plays an important role in the growth and metastasis of malignant tumors. We have previously reported that in children with neuroblastoma (NB), tumor vascularity directly correlates with metastatic disease, MYCN amplification, and poor outcome. The angiogenesis inhibitor TNP-470 has been shown to reduce the rate of NB growth in rodents with macroscopic tumors without ultimately impacting survival. To investigate whether TNP-470 could more effectively inhibit NB growth in animals with a low tumor burden, we treated 30 nude mice with minimal disease with this angiogenesis inhibitor (supplied by TAP Pharmaceuticals, Inc.). Therapy was initiated before tumors were clinically evident after s.c. inoculation of 5 x 10(6) cells from the MYCN-amplified NB cell line NBL-W-N. TNP-470 was administered 3 days/week, and after 12 weeks of treatment, 53% of the treated mice remained tumor free, whereas 100% of the control mice developed tumors (P < 0.0001). To further assess the relationship between the efficacy of TNP-470 treatment and tumor burden, TNP-470 was also administered s.c., 3 days/week, to mice with clinically evident small (<400 mm3; n = 15) and large (>400 mm3; n = 11) tumors. For animals with small tumors, the mean rate of growth was significantly decreased in the treated mice compared to the controls (P = 0.02). In contrast, there was no difference in the mean rate of tumor growth between animals with large tumors treated with TNP-470 and controls (P = 0.64). Our studies demonstrate that the effectiveness of TNP-470 inversely correlates with tumor burden. We speculate that TNP-470 may most effectively inhibit NB tumor growth in children with a low tumor burden. |
| معلومات مُعتمدة: | 5P30CA60553 United States CA NCI NIH HHS; CA74824 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Antibiotics, Antineoplastic) 0 (Cyclohexanes) 0 (Growth Inhibitors) 0 (Sesquiterpenes) X47GR46481 (O-(Chloroacetylcarbamoyl)fumagillol) |
| تواريخ الأحداث: | Date Created: 20000113 Date Completed: 20000214 Latest Revision: 20181130 |
| رمز التحديث: | 20231215 |
| PMID: | 10632370 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1078-0432 |
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