دورية أكاديمية
Cerebrovascular effects of the TRH analogues pGlu-3-methyl-His-Pro amide and pGlu-Glu-Pro amide: a comparison with TRH.
| العنوان: | Cerebrovascular effects of the TRH analogues pGlu-3-methyl-His-Pro amide and pGlu-Glu-Pro amide: a comparison with TRH. |
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| المؤلفون: | Koskinen LO; Department of Biomedicine, Umeå University Hospital, Sweden. Lars-Owe.Koskinen@neuro.umu.se, Koch ML, Svedberg J |
| المصدر: | Upsala journal of medical sciences [Ups J Med Sci] 2000; Vol. 105 (1), pp. 73-83. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Upsala Medical Society Country of Publication: Sweden NLM ID: 0332203 Publication Model: Print Cited Medium: Print ISSN: 0300-9734 (Print) Linking ISSN: 03009734 NLM ISO Abbreviation: Ups J Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Uppsala, Sweden : Upsala Medical Society Original Publication: Uppsala : Stockholm : Upsala Medical Society ; distributed by Almqvist & Wiksell |
| مواضيع طبية MeSH: | Cerebrovascular Circulation/*drug effects , Hemodynamics/*drug effects , Thyrotropin-Releasing Hormone/*analogs & derivatives , Thyrotropin-Releasing Hormone/*pharmacology , Vasodilator Agents/*pharmacology, Animals ; Blood Gas Analysis ; Dose-Response Relationship, Drug ; Laser-Doppler Flowmetry ; Male ; Molecular Structure ; Pyrrolidonecarboxylic Acid/analogs & derivatives ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | The goal of the study was to assess whether TRH analogues possess cerebrovascular effects similar to the native peptide. The neuropeptide thyrotropin releasing hormone (TRH) elicits cerebrovasodilation in several species under various conditions. The laser-Doppler method was employed to study the effects of TRH and the analogues pGlu-3-methyl-His-Pro amid (M-TRH) and pGlu-Glu-Pro amide. Intravenous (i.v.) injection of 300 microg kg(-1) of TRH elicited cerebrovasodilation and a 62% increase in blood flow within 1 minute. M-TRH, in a dose of 300 microg kg(-1) i.v., elicited a 80% increase in cerebral blood flow. Even a minute dose of M-TRH (625 ng kg(-1)) caused an increase in cerebral blood flow. No clear difference in effects on the cerebral blood flow was observed between spontaneously and mechanically ventilated animals, pGlu-Glu-Pro amide had no cerebrovascular effect. |
| المشرفين على المادة: | 0 (Vasodilator Agents) 34367-54-9 (thyrotropin-releasing hormone, 3-Me-) 5Y5F15120W (Thyrotropin-Releasing Hormone) 85541-78-2 (pyroglutamyl-glutamyl-proline amide) SZB83O1W42 (Pyrrolidonecarboxylic Acid) |
| تواريخ الأحداث: | Date Created: 20000713 Date Completed: 20001019 Latest Revision: 20190515 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1517/03009734000000049 |
| PMID: | 10893055 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0300-9734 |
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| DOI: | 10.1517/03009734000000049 |