دورية أكاديمية
[Modern concept of peripheral erectile mechanisms].
| العنوان: | [Modern concept of peripheral erectile mechanisms]. |
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| عنوان ترانسليتريتد: | Suchasni uiavlennia shchodo periferychnykh mekhanizmiv erektsiï. |
| المؤلفون: | Boiko MI; Institute of Urology and Nephrology, Academy of Medical Sciences of Ukraine, Kiev., Nurimanov KR |
| المصدر: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2001; Vol. 47 (1), pp. 116-32. |
| نوع المنشور: | English Abstract; Journal Article; Review |
| اللغة: | Ukrainian |
| بيانات الدورية: | Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kyiv : Naukova Dumka Original Publication: Kyïv : Nauk. dumka, 1994- |
| مواضيع طبية MeSH: | Penile Erection/*physiology , Penis/*physiology, Animals ; Calcium/metabolism ; Gap Junctions/physiology ; Humans ; Male ; Muscle Contraction/physiology ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/physiology ; Muscle Relaxation/physiology ; Muscle Tonus/physiology ; Muscle, Smooth/blood supply ; Muscle, Smooth/innervation ; Muscle, Smooth/physiology ; Neurotransmitter Agents/physiology ; Nitric Oxide/metabolism ; Nucleotides, Cyclic/metabolism ; Oxygen/metabolism ; Penis/blood supply ; Penis/innervation ; Second Messenger Systems/physiology |
| مستخلص: | The article describes the peripheral mechanisms of erection and control over them. This knowledge has been acquired as a result of the recent development of pharmacological research designed to study the regulation of erectile smooth muscle tone. Smooth muscle fibres of the corpora cavernosa and arteries supplying the penis relax in response to a reduction of intracellular calcium. This relaxation allows both an increase of the blood flow to the penis and opening of sinusoid spaces. Cyclic nucleotides, cGMP and cAMP, are intracellular messengers of the mediators acting on smooth muscle fibres and regulating these intracellular calcium movements. Nitric oxide (NO) increases the intracellular cGMP concentration that triggers relaxation. Other proerectile mediators, such as vasoactive intestinal polypeptide, prostaglandin E1, are of the secondary importance. In contrast, neurotransmitters of the sympathetic nervous system (norepinephrine), neuropeptide Y, and endothelin induce contraction of cavernous smooth muscle fibres, thereby opposing erection. Oxygenation of the cavernous tissue is also an important factor in the regulation of local mechanisms of erection. Regulation of calcium sensitivity as well as functioning of intracellulare contact--gap junction are of certain interest. A better understanding of the peripheral pharmacology of erection opens the way to new pathophysiological and therapeutic prospects in the broad context of erectile dysfunction. |
| Number of References: | 116 |
| المشرفين على المادة: | 0 (Neurotransmitter Agents) 0 (Nucleotides, Cyclic) 31C4KY9ESH (Nitric Oxide) S88TT14065 (Oxygen) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20010412 Date Completed: 20020618 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 11296549 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2522-9028 |
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