التفاصيل البيبلوغرافية
| العنوان: |
Comparison of in vitro closure time (PFA-100) with whole blood electrical aggregometry and platelet surface antigen expression in healthy volunteers. |
| المؤلفون: |
Salat A; Department of General Surgery, University of Vienna, Waehringer Guertel 18-20, A-1090, Austria. andreas.salat@univie.ac.at, Kroess S, Felfernig-Boehm D, Felfernig M, Fleck T, Schmidt D, Pulaki S, Mueller MR |
| المصدر: |
Thrombosis research [Thromb Res] 2002 Feb 01; Vol. 105 (3), pp. 205-8. |
| نوع المنشور: |
Comparative Study; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Pergamon Press Country of Publication: United States NLM ID: 0326377 Publication Model: Print Cited Medium: Print ISSN: 0049-3848 (Print) Linking ISSN: 00493848 NLM ISO Abbreviation: Thromb Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: |
Platelet Aggregation*, Antigens, CD/*analysis , Blood Platelets/*immunology, Antigens, CD/immunology ; Hemostasis ; Humans ; Platelet Function Tests ; Time Factors |
| مستخلص: |
It was the aim of this study to compare in vitro closure time (PFA-100), reflecting platelet-related primary hemostasis, to more platelet-specific tests like whole blood electrical aggregometry and platelet surface antigen expression in healthy volunteers. In vitro closure time was measured using a PFA-100. Platelet surface antigen expression (CD63, CD62-P, CD42b, CD36, CD31) was determined in accordance with the consensus protocol for flow-cytometric characterisation of platelet function. Platelet aggregometry was performed using a whole blood electrical aggregometer (ADP and arachidonic acid as agonists). Analysis of the obtained data revealed only a few significant correlations between the different platelet function tests used. This finding can be explained by the various aspects of platelet function being focused by these tests in different extents. Whenever platelet function is analysed, the investigator should be aware of the specific and limited evidence of the method used. For screening purposes, it may be useful to introduce a platelet function index, referring to basal platelet activity, platelet adhesion and platelet aggregation at low and high shear stress forces. |
| المشرفين على المادة: |
0 (Antigens, CD) |
| تواريخ الأحداث: |
Date Created: 20020403 Date Completed: 20020827 Latest Revision: 20190727 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1016/s0049-3848(02)00019-1 |
| PMID: |
11927125 |
| قاعدة البيانات: |
MEDLINE |
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