دورية أكاديمية
[The changes of cardiovascular response to orthostatic stress caused by hypovolemia induced by weightlessness: a simulation study].
| العنوان: | [The changes of cardiovascular response to orthostatic stress caused by hypovolemia induced by weightlessness: a simulation study]. |
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| المؤلفون: | Hao W; Department of Electrical Engineering, Tsinghua University, Beijing 100084., Bai J, Zhang L, Wu X |
| المصدر: | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi [Sheng Wu Yi Xue Gong Cheng Xue Za Zhi] 2002 Jan; Vol. 19 (1), pp. 48-52. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Sichuan Sheng sheng wu yi xue gong cheng xue hui Country of Publication: China NLM ID: 9426398 Publication Model: Print Cited Medium: Print ISSN: 1001-5515 (Print) Linking ISSN: 10015515 NLM ISO Abbreviation: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui Original Publication: Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui : Hua xi yi ke da xue : Chengdu ke ji da xue, |
| مواضيع طبية MeSH: | Cardiovascular Deconditioning/*physiology , Hypotension, Orthostatic/*physiopathology , Hypovolemia/*physiopathology , Lower Body Negative Pressure/*adverse effects , Weightlessness Simulation/*adverse effects, Adult ; Blood Pressure/physiology ; Computer Simulation ; Heart Rate/physiology ; Humans ; Hypotension, Orthostatic/etiology ; Hypovolemia/etiology ; Male ; Models, Cardiovascular ; Ventricular Function, Left/physiology |
| مستخلص: | We introduced the method of computer simulation in the studies of gravitational physiology. Based on work of Melchior (1994), we developed a mathematical model that can be used to stimulate cardiovascular responses to orthostatic stress (lower body negative pressure, LBNP). The model includes 7 sub-models: the redistribution of blood, the filling of left ventricle, left ventricle working, peripheral circulation, control of heart rate (HR), control of peripheral resistance and control of venous tone. Then we simulated the changes of blood pressure (BP) and heart rate during lower body negative pressure, and the results agreed well with the results of our human experiment. By using the developed model, we also simulated the effects of hypovolemia on the BP, HR and shock index during orthostatic stress. The simulation results indicate that the cardiovascular responses to orthostatic stress change significantly when the decrease of blood volume is more than 15% of the total blood volume. However, if the amount of the decrease of blood volume is less than 5% of the total blood volume, HR and BP could be maintained in normal range by the regulation of baroreflex during LBNP. Our simulation results suggest that hypovolemia may be the main cause of orthostatic intolerance induced by weightlessness. |
| تواريخ الأحداث: | Date Created: 20020416 Date Completed: 20030220 Latest Revision: 20061115 |
| رمز التحديث: | 20221213 |
| PMID: | 11951522 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5515 |
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