دورية أكاديمية
Closing in on the biological functions of Fps/Fes and Fer.
| العنوان: | Closing in on the biological functions of Fps/Fes and Fer. |
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| المؤلفون: | Greer P; Division of Cancer Research and Genetics, Queen's University Cancer Research Institute, Kingston, Ontario K7L 3N6, Canada. greerp@post.queensu.ca |
| المصدر: | Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2002 Apr; Vol. 3 (4), pp. 278-89. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print Cited Medium: Print ISSN: 1471-0072 (Print) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Nature Pub. Group, [2000- |
| مواضيع طبية MeSH: | Fusion Proteins, gag-onc/*physiology , Protein-Tyrosine Kinases/*physiology , Proto-Oncogene Proteins/*physiology, Animals ; Biological Evolution ; Chromosomes, Human, Pair 15/genetics ; Chromosomes, Human, Pair 5/genetics ; Fusion Proteins, gag-onc/chemistry ; Fusion Proteins, gag-onc/genetics ; Humans ; Inflammation/physiopathology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Models, Biological ; Models, Molecular ; Protein Structure, Tertiary ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/genetics ; Receptor Cross-Talk ; Receptors, Platelet-Derived Growth Factor/physiology ; Signal Transduction |
| مستخلص: | Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family. Recent studies indicate that these kinases have roles in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions. Genetic analysis using transgenic mouse models also implicates these kinases in the regulation of inflammation and innate immunity. |
| Number of References: | 123 |
| المشرفين على المادة: | 0 (Fusion Proteins, gag-onc) 0 (Proto-Oncogene Proteins) 110736-90-8 (proto-oncogene protein c-fes-fps) EC 2.7.10.1 (Protein-Tyrosine Kinases) EC 2.7.10.1 (Receptors, Platelet-Derived Growth Factor) EC 2.7.10.2 (v-fps oncogene protein, Fujinami sarcoma virus) |
| تواريخ الأحداث: | Date Created: 20020508 Date Completed: 20020529 Latest Revision: 20120601 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1038/nrm783 |
| PMID: | 11994747 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1471-0072 |
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| DOI: | 10.1038/nrm783 |