دورية أكاديمية
The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice.
| العنوان: | The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice. |
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| المؤلفون: | Malecki EA; Department of Neuroscience and Anatomy, College of Medicine, The Pennsylvania State University, Hershey 17033, USA., Cable EE, Isom HC, Connor JR |
| المصدر: | Biological trace element research [Biol Trace Elem Res] 2002 Apr; Vol. 86 (1), pp. 73-84. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print Cited Medium: Print ISSN: 0163-4984 (Print) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London, Clifton, N. J.] Humana Press. |
| مواضيع طبية MeSH: | Brain/*drug effects , Ferritins/*analysis , Ferrous Compounds/*toxicity , Heme Oxygenase (Decyclizing)/*biosynthesis , Iron/*metabolism , Neurons/*chemistry, Animals ; Brain/metabolism ; Female ; Immunohistochemistry ; Male ; Metallocenes ; Mice ; Mice, Inbred BALB C ; Staining and Labeling |
| مستخلص: | Mismanagement of intracellular iron is a key pathological feature of many neurodegenerative diseases. Our long-term goal is to use animal models to investigate the mechanisms of iron neurotoxicity and its relationship to neurodegenerative pathologies. The immediate aim of this experiment was to determine regional distribution of iron and cellular distribution of iron storage proteins (L- and H-ferritin) and an oxidative stress marker (heme oxygenase-1) in brains of mice fed the lipophilic iron compound (3,5,5-trimethylhexanoyl) (TMH)-ferrocene. We fed male and female weanling BALB/cj mice diets either deficient in iron (0 mg Fe/kg diet), adequate in iron (35 mg Fe/kg diet; control mice), or adequate in iron and supplemented with 0.1 or 1.0 g TMH-ferrocene/kg diet for 8 wk. Iron concentrations in cerebrum were higher in mice fed 1.0 g TMH-ferrocene/kg diet than in control mice (p < 0.05). Liver iron concentrations were eightfold higher in mice fed 1.0 g TMH-ferrocene/kg diet than in control mice (p < 0.0001). L-Ferritin and heme oxygenase-1 expression were elevated in striatum in mice fed 1.0 g TMH-ferrocene/kg diet. We conclude that administration of the lipophilic iron compound TMH-ferrocene leads to subtle perturbations of cellular iron within the brain, potentially representing a model of iron accumulation similar to that seen in various neuropathological conditions. |
| معلومات مُعتمدة: | CA23931 United States CA NCI NIH HHS; DK53430 United States DK NIDDK NIH HHS; DK54482 United States DK NIDDK NIH HHS; NS34280 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Ferrous Compounds) 0 (Metallocenes) 67527-18-8 (3,5,5-trimethylhexanoylferrocene) 9007-73-2 (Ferritins) E1UOL152H7 (Iron) EC 1.14.14.18 (Heme Oxygenase (Decyclizing)) |
| تواريخ الأحداث: | Date Created: 20020511 Date Completed: 20021024 Latest Revision: 20191210 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1385/BTER:86:1:73 |
| PMID: | 12002662 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0163-4984 |
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| DOI: | 10.1385/BTER:86:1:73 |