دورية أكاديمية
VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.
| العنوان: | VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology. |
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| المؤلفون: | Magez S; Laboratory of Cellular Immunology, Free University of Brussels/Flemish Interuniversity, Institute for Biotechnology, Paardenstraat 65, Sint Genesius Rode, Belgium. stemagez@vub.ac.be, Stijlemans B, Baral T, De Baetselier P |
| المصدر: | Microbes and infection [Microbes Infect] 2002 Jul; Vol. 4 (9), pp. 999-1006. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: France NLM ID: 100883508 Publication Model: Print Cited Medium: Print ISSN: 1286-4579 (Print) Linking ISSN: 12864579 NLM ISO Abbreviation: Microbes Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris ; New York : Elsevier, c1999- |
| مواضيع طبية MeSH: | Glycosylphosphatidylinositols/*immunology , Glycosylphosphatidylinositols/*physiology , Macrophages/*immunology , Trypanosomiasis/*immunology , Trypanosomiasis/*physiopathology , Variant Surface Glycoproteins, Trypanosoma/*immunology , Variant Surface Glycoproteins, Trypanosoma/*physiology, Africa ; Animals ; Glycosylphosphatidylinositols/chemistry ; Humans ; Macrophage Activation ; Macrophages/metabolism ; Trypanosoma brucei gambiense/immunology ; Trypanosoma brucei gambiense/pathogenicity ; Trypanosoma brucei rhodesiense/immunology ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis/metabolism ; Trypanosomiasis/veterinary ; Type C Phospholipases/metabolism ; Vaccination ; Variant Surface Glycoproteins, Trypanosoma/chemistry |
| مستخلص: | African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology. |
| المشرفين على المادة: | 0 (Glycosylphosphatidylinositols) 0 (Variant Surface Glycoproteins, Trypanosoma) EC 3.1.4.- (Type C Phospholipases) |
| تواريخ الأحداث: | Date Created: 20020711 Date Completed: 20020919 Latest Revision: 20191106 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/s1286-4579(02)01617-9 |
| PMID: | 12106794 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1286-4579 |
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| DOI: | 10.1016/s1286-4579(02)01617-9 |